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Autor:
Stephen S. Rich, Donna Neuberg, Michael H. Cho, Bing Yu, Matthew Leventhal, George T. O'Connor, Ani Manichaikul, Weiwei Shi, Lynette M. Sholl, Michael C. Honigberg, Abhishek Niroula, Benjamin L. Ebert, Joselyn Rojas-Quintero, R. Graham Barr, Matthew Moll, Stephanie J. London, L. Adrienne Cupples, Siddhartha Jaiswal, Elizabeth C. Oelsner, Brittany E Sandoval, Pradeep Natarajan, Brian E. Cade, Peter van Galen, Susan Redline, Yohannes Tesfaigzi, Christopher J. Gibson, Stephanie M. Gogarten, COPDGene Study Investigators, Deepti Jain, Adolfo Correa, Bruce D. Levy, Sina A. Gharib, Peter Miller, Kaushik Viswanathan, Caroline A. Owen, Edwin K. Silverman, Lillian Werner, Jerome I. Rotter, Dandi Qiao, Brian C. Miller, Adam S. Sperling, Leslie A. Lange, Alexander G. Bick, Marie McConkey, Vasan S. Ramachandran
Publikováno v:
Blood. 139:357-368
Chronic obstructive pulmonary disease (COPD) is associated with age and smoking, but other determinants of the disease are incompletely understood. Clonal hematopoiesis of indeterminate potential (CHIP) is a common, age-related state in which somatic
Autor:
Angeles Fernandez-Gonzalez, S. Alex Mitsialis, Lawrence S. Prince, Xianlan Liu, Vincent Yeung, Stella Kourembanas, Gareth R. Willis, Elizabeth S. Taglauer, Monica Reis
Publikováno v:
Am J Respir Cell Mol Biol
In preeclamptic pregnancies, a variety of intrauterine alterations lead to abnormal placentation, release of inflammatory and/or antiangiogenic factors, and subsequent fetal growth restriction with significant potential to cause a primary insult to t
Autor:
Nataša Ristić, Jasmina Sretenovic, Kristina Andric, Jovan Rudic, Maja Nikolic, Jovana Joksimovic Jovic, Verica Milošević, Nikola Jovic, Biljana Milicic, Tijana Dimkic Tomic, Vladimir Zivkovic, Vladimir Jakovljevic
Publikováno v:
Reproduction. 163:11-21
Numerous evidence implies complex interrelations between polycystic ovary syndrome (PCOS) and hypertension (HT) in reproductive-age women. In this study, we aimed to investigate the potential strain differences in ovarian morphology, hemodynamic, and
Autor:
Wenzhen Gao, Minqi Li, Shanshan Liu, Rongjian Su, Tomoka Hasegawa, Juan Du, Qin Zhou, Yupu Lu
Publikováno v:
International Journal of Biological Sciences
Background: Oral squamous cell carcinoma (OSCC) refers to the malignant tumor of the head and neck with a highest morbidity. It exhibits a poor prognosis and unsatisfactory treatment, which is partially attributed to delayed diagnosis. As indicated f
Autor:
Robert Zeiser, Takanori Teshima
Publikováno v:
Blood. 138:2165-2172
Acute graft-versus-host disease (GVHD) is a major life-threatening complication after allogeneic hematopoietic cell transplantation (allo-HCT). The classical target organs of acute GVHD include the intestines, liver, and skin. The damage of these org
Autor:
Ingrid Langer, F. Guerif, Pascal Froment, Alice Bongrani, Claire Petit, Anthony Estienne, Namya Mellouk, Joëlle Dupont, Christelle Ramé, Ingrid Plotton
Publikováno v:
Reproduction
Reproduction, BioScientifica, 2021, 162 (6), pp.427-436. ⟨10.1530/REP-21-0265⟩
Reproduction, BioScientifica, 2021, 162 (6), pp.427-436. ⟨10.1530/REP-21-0265⟩
Polycystic ovarian syndrome (PCOS) is the main cause of infertility in women. It is frequently associated with reduced progesterone production by human luteinised granulosa cells (hlGCs). However, the molecular mechanisms involved in these steroidoge
Autor:
Hai Liu, Yiyang Hong, Guanyu Wang, Haozhe Li, Xingjian Dong, Jingjing Tao, Anyong Xie, Yili Feng, Yihong Wang, Zhenyu Liuyang, Qinghua Dong, Jing Zhang, Zhongyang Jiang
Publikováno v:
Oxidative Medicine and Cellular Longevity, Vol 2021 (2021)
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity
Radiation-induced oral mucositis is a major adverse event of radiotherapy. Severe oral mucositis may cause unwanted interruption in radiotherapy and reduce long-term survival in cancer patients receiving radiotherapy, but until now, there have been n
Autor:
Amanda Kofides, Kirsten Meid, Sara J. Buhrlage, Jinhua Wang, Manit Munshi, Jorge J. Castillo, Jiaji G. Chen, Kenneth C. Anderson, Michael D. Cameron, Guang Yang, Maria Luisa Guerrera, Xia Liu, Lian Xu, Nicholas Tsakmaklis, Nikhil C. Munshi, Jianwei Che, Li Tan, Maria Demos, Nathanael S. Gray, Christopher J. Patterson, Steven P. Treon, Zachary R. Hunter
Publikováno v:
Blood
Activating mutations in MYD88 promote malignant cell growth and survival through hematopoietic cell kinase (HCK)–mediated activation of Bruton tyrosine kinase (BTK). Ibrutinib binds to BTKCys481 and is active in B-cell malignancies driven by mutate
Publikováno v:
Aging (Albany NY)
Aim To explore the immunoregulatory effects of circ_CELF1 in non-small cell lung cancer (NSCLC). Methods The mRNA level of circ_CELF1 in primary tissue samples was analyzed by qRT-PCR. The assays of CCK-8, colony formation, wound healing as well as T
Autor:
Iara Viana Vidigal Santana, Rodrigo de Oliveira Cavagna, Pedro De Marchi, Leticia Ferro Leal, Flavio Augusto Ferreira da Silva, Gustavo Noriz Berardinelli, Vinicius Duval da Silva, Eduardo Caetano Albino da Silva, Rui Manuel Reis, Icaro Alves Pinto
Publikováno v:
Pathobiology. 89:101-106
Background: Microsatellite instability (MSI) in non-small cell lung cancer (NSCLC) is uncommon; however, most studies refer to European and Asian populations. There are currently no data on MSI frequency in highly admixed populations, such as the one