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Autor:
Atsushi Hoshino, Shunta Taminishi, Yoshito Minami, Satoaki Matoba, Ryota Urata, Tomohiro Hino, Takashi Nakagawa, Yohei Fushimura, Eri Iwai-Kanai, Satoru Furukawa
Publikováno v:
Biochemical and Biophysical Research Communications. 585:191-195
Impairment of pancreatic β cells is a principal driver of the development of diabetes. Restoring normal insulin release from the β cells depends on the ATP produced by the intracellular mitochondria. In maintaining mitochondrial function, the tumor
Publikováno v:
Biochemical and Biophysical Research Communications. 580:1-6
Sphingosine kinase 2 (SphK2) inhibitors are developed for tumor therapy as considering its anti-tumor effect. Many studies also explored SphK2 modulated glucose and lipid homeostasis, which extended its potential function for metabolic diseases thera
Severe steatosis and mild colitis are important for the early occurrence of hepatocellular carcinoma
Autor:
Masaru Kumagai, Shunsuke Nojiri, Atsunori Tsuchiya, Shuji Terai, Satoko Motegi, Takeki Sato, Suguru Takeuchi, Takashi Owaki, Yusuke Watanabe, Takahiro Iwasawa, Masahiro Ogawa, Yuzo Kawata, Hiroteru Kamimura
Publikováno v:
Biochemical and Biophysical Research Communications. 566:36-44
The number of patients with non-alcoholic steatohepatitis (NASH) and inflammatory bowel disease (IBD) is increasing. This study elucidates the effect of both NASH and IBD on hepatocellular carcinoma (HCC) using a mouse model combining NASH and IBD. T
Autor:
Arisa Ochi, Yasumasa Ikeda, Naoki Kashihara, Kojiro Nagai, Kensei Taguchi, Masanori Tamaki, Ken-ichi Aihara, Hideharu Abe, Masashi Miyoshi, Craig R. Brooks, Hiroyuki Kadoya, Kenji Nishimura, Seiji Kishi
Publikováno v:
Biochemical and Biophysical Research Communications. 556:142-148
The relationship between cellular senescence and fibrosis in the kidney is being elucidated and we have identified it as therapeutic target in recent studies. Chronic kidney disease has also become a lifestyle disease, often developing on the backgro
Autor:
Wei Wang, Chen Xing, Min Zhang, Yifan Zhang, Lun Song, Mengnan Ding, Beifen Shen, Lin Wu, Chongchong Zhang, Chunfeng Lu, Xin Huang, Yu Gu
Publikováno v:
Biochemical and Biophysical Research Communications. 559:217-221
Ornithine transcarbamylases (OTC), a key enzyme in urea cycle, is an important marker for some liver injury or diseases. However, whether OTC could be a sensitive indicator for liver dysfunction under sleep disturbance condition remains unknown. The
Publikováno v:
Biochemical and Biophysical Research Communications. 555:54-60
Non-alcoholic fatty liver disease (NAFLD) is the pathological manifestation of metabolic syndrome in liver. Its pathological changes may evolve from the initial simple steatosis to non-alcoholic steatohepatitis, liver fibrosis and even liver cancer.
Autor:
Zhizhuo Huang, Yujun Hao, Jie Yang, Baoyu He, Shishun Huang, Hongli Pan, Delan Luo, Wei Chao, Jianchao Zeng
Publikováno v:
Biochemical and Biophysical Research Communications. 551:100-106
Colorectal cancer (CRC) is prevalent worldwide and novel diagnostic and prognostic biomarkers are needed to improve precision medicine. Circular RNAs (circRNAs) are currently being considered as emerging tumor biomarkers. Herein, we aimed to explore
Publikováno v:
FEBS Letters. 595:1313-1321
The molecular mechanisms generating the mania-like abnormal behaviors caused by diacylglycerol (DG) kinase (DGK) η deficiency remain unclear. Here, we found that DGKη knockout markedly increased dopamine (DA) levels in the midbrain (DA-producing re
Publikováno v:
Biochemical and Biophysical Research Communications. 545:1-7
Mammary epithelial cells synthesize and secrete norepinephrine (NE) into breast milk to regulate β-casein expression through the adrenergic β2 receptor. We investigated the expression, localization, and roles of NE transporter (NET) in the mammary
Autor:
Rena Senda, Keigo Katayama, Akihito Morita, Yuki Shimba, Shinji Miura, Yasutomi Kamei, Masahiko Ikeda
Publikováno v:
Biochemical and Biophysical Research Communications. 540:61-66
Calorie restriction (CR) reportedly prevents atherosclerotic diseases. Furthermore, CR induces forkhead box protein-O1 (FOXO-1) expression in the skeletal muscle, altering the character of the skeletal muscle. We previously reported that the change i