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pro vyhledávání: ''
Autor:
Jae-Hyun Lee, Chang-Min Lee, Joyce H. Lee, Mun-Ock Kim, Jin Wook Park, Suchitra Kamle, Bedia Akosman, Erica L. Herzog, Xue Yan Peng, Jack A. Elias, Chun Geun Lee
Publikováno v:
Am J Respir Cell Mol Biol
RationalePulmonary fibrosis is a devastating lung disease with few therapeutic options. Chitinase 1 (CHIT1), an 18 glycosyl hydrolase family member, contributes to the pathogenesis of pulmonary fibrosis through regulation of Transforming Growth Facto
Publikováno v:
Laboratory Investigation. 102:411-421
Acute lymphoblastic leukemia (ALL) is a common malignancy in children. In this study, we aimed to explore putative mechanisms of microRNA-155-5p (miR-155-5p) involvement in childhood ALL (cALL) via interactions with casitas B-lineage lymphoma (CBL),
Autor:
Jianqiang Li, Hui Zhao, Pingping Li, Shuyin Zhi, Ruina Li, Lifang Li, Jian-Nan Gong, Guang Yang
Publikováno v:
Laboratory Investigation. 102:272-280
Patients with chronic obstructive pulmonary disease (COPD) are characterized by an imbalance between oxidant enzymes and antioxidant enzymes. In the present study, we explored the protective effect of vitamin E on COPD and the underlying mechanisms.
Autor:
Paul M. Daniel, Frédéric Hollande, Andrew P. Morokoff, Gulay Filiz, Sebastian Dworkin, Theo Mantamadiotis, Daniel Brown, Wayne Ng, Nicole Kountouri, Stephanie Amiridis
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 2, p e0172791 (2017)
PLoS ONE, Vol 12, Iss 2, p e0172791 (2017)
Glioblastoma (GBM) is a heterogeneous tumor of the brain with a poor prognosis due to recurrence and drug resistance following therapy. Genome-wide profiling has revealed the existence of distinct GBM molecular subtypes that respond differently to ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b93541fc9763c8c99c234f613764a359
Autor:
Alain Fournier, Marielle Chiron, Nadège Carrié, Sukhvinder Sidhu, Marine Cuisinier, Sahar Kassem, Dmitri Wiederschain, Hélène Bonnevaux, Jean-Luc Teillaud, Ludovic Martinet, Helgi van de Velde, Jill Corre, Isabelle Arnould, Béré K. Diallo, Nizar El-Murr, Céline Nicolazzi, Angela Virone-Oddos, Hervé Avet-Loiseau, Alexandre Tang
Publikováno v:
Blood. 139:1160-1176
Anti-CD38 monoclonal antibodies (mAbs) represent a breakthrough in the treatment of multiple myeloma (MM), yet some patients fail to respond or progress quickly with this therapy, highlighting the need for novel approaches. In this study we compared
Autor:
Hiroshi Imanaga, Tatsuya Terasaki, Koichi Akashi, Kensuke Sasaki, Fumihiko Nakao, Takeshi Inukai, Jumpei Nogami, Takahiro Maeda, Els Verhoeyen, Takuji Yamauchi, Koshi Akahane, Yuichiro Semba
Publikováno v:
Blood
Acute lymphoblastic leukemia (ALL) harboring the IgH-CRLF2 rearrangement (IgH-CRLF2-r) exhibits poor clinical outcomes and is the most common subtype of Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL). While multiple chemother
Autor:
Abhinav Dey, Bing Yu, Kishore Kumar Jella, Anshu Malhotra, Jingbo Liu, Liangping Yuan, Tobey J. MacDonald, Matthew Schniederjan, Hongying Zhang, Leon F. McSwain
Publikováno v:
Molecular Oncology, Vol 16, Iss 4, Pp 1009-1025 (2022)
Sonic hedgehog (Shh)-driven medulloblastoma (Shh MB) cells are dependent on constitutive Shh signaling, but targeted treatment of Shh MB has been ineffective due to drug resistance. The purpose of this study was to address the critical role of signal
Autor:
Jean-Paul Courneya, Rita Fishelevich, Irina G. Luzina, Violeta Rus, Sergei P. Atamas, Brian Hampton, Alexander V. Misharin, Nevins W. Todd, Virginia Lockatell, Tudor C. Badea, Horea Rus
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 66:146-157
Some previous studies in tissue fibrosis have suggested a profibrotic contribution from elevated expression of a protein termed either Regulator of Cell Cycle (RGCC) or Response Gene to Complement 32 Protein (RGC-32). Our analysis of public gene expr
Publikováno v:
International Journal of Biological Sciences
Simultaneous P53 loss and activation of the PTEN-restricted PI3K-AKT pathway frequently occur in aggressive breast cancers. P53 loss causes genome instability, while PTEN loss and/or activating mutations of PIK3CA and AKT promote cancer cell prolifer
Publikováno v:
Seminars in Cell & Developmental Biology. 121:10-23
Sertoli cells (SCs) are immune privileged cells found in the testis that function to immunologically protect maturing germ cells from immune destruction. This immune protection is due to the blood-testis-barrier, which prevents infiltration of cytoto