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Publikováno v:
Current Neuropharmacology. 20:1579-1599
Pain is a complex phenomenon that is usually unpleasant and aversive. It can range widely in intensity, quality, and duration and has diverse pathophysiologic mechanisms and meanings. Voltage-gated sodium and calcium channels are essential to transmi
Publikováno v:
Cannabis Cannabinoid Res
INTRODUCTION: Medicinal cannabis has proliferated around the world and there is increasing interest in the therapeutic potential of individual plant-derived cannabinoids (phytocannabinoids). Preclinical evidence suggests the phytocannabinoid cannabig
Autor:
Matheus Marcon, Cristina R. Reschke, Ana Paula Herrmann, Matheus Gallas-Lopes, Radharani Benvenutti, Angelo Luis Stapassoli Piato
Publikováno v:
Current Neuropharmacology. 20:494-509
Schizophrenia pathophysiology is associated with hypofunction of glutamate NMDA receptors (NMDAR) in GABAergic interneurons and dopaminergic hyperactivation in subcortical brain areas. The administration of NMDAR antagonists is used as an animal mode
Autor:
Ajib Diptyanusa, Ika Puspa Sari
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 17, Iss, Pp 128-138 (2021)
International Journal for Parasitology: Drugs and Drug Resistance
International Journal for Parasitology: Drugs and Drug Resistance
The global burden of diarrhea caused by Cryptosporidium parasite is underestimated. In immunocompromised hosts, chronic and severe presentation of intestinal cryptosporidiosis can result in long-term morbidity and high illness costs. The evidence of
Publikováno v:
J Antimicrob Chemother
ObjectivesComplicated urinary tract infections (cUTIs) are frequently encountered in hospitals and ICUs. Increasingly, the causative pathogens harbour enzymatic resistance mechanisms. Taniborbactam is a novel β-lactamase inhibitor with activity agai
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance
International Journal for Parasitology: Drugs and Drug Resistance, Vol 17, Iss, Pp 156-167 (2021)
International Journal for Parasitology: Drugs and Drug Resistance, Vol 17, Iss, Pp 156-167 (2021)
Cryptosporidiosis has been considered as a serious diarrheal disease, especially in immunodeficient patients, where they failed to clear the infection leading to several consequences of infection (i.e death). The role of cell mediated immunity in cle
Autor:
Jared W. Young, Arpi Minassian, Benjamin Z Roberts, Adam L. Halberstadt, Yinong V He, Muhammad Chatha, Igor Grant, Mark A. Geyer
Publikováno v:
International Journal of Neuropsychopharmacology
Background HIV-associated neurocognitive disorder (HAND) is commonly observed in persons living with HIV (PWH) and is characterized by cognitive deficits implicating disruptions of fronto-striatal neurocircuitry. Such circuitry is also susceptible to
Autor:
Stanton F. McHardy, Jayce Rhodes, Philip T. LoVerde, Sevan N. Alwan, Alexander B. Taylor, Frédéric D. Chevalier, Tim J. Anderson
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 16, Iss, Pp 140-147 (2021)
International Journal for Parasitology: Drugs and Drug Resistance
International Journal for Parasitology: Drugs and Drug Resistance
Human schistosomiasis is a debilitating, life-threatening disease affecting more than 229 million people in as many as 78 countries. There is only one drug of choice effective against all three major species of Schistosoma, praziquantel (PZQ). Howeve
Publikováno v:
Expert Opinion on Pharmacotherapy, 22, 15, pp. 1961-1974
Expert Opinion on Pharmacotherapy, 22, 1961-1974
Expert Opinion on Pharmacotherapy, 22, 1961-1974
Contains fulltext : 238315.pdf (Publisher’s version ) (Open Access) Introduction: Guidelines recommend the use of amikacin in the treatment of nontuberculous mycobacterial (NTM) disease. The authors have evaluated the evidence for the position of a
Publikováno v:
Journal of Antimicrobial Chemotherapy. 76:2629-2635
Objectives Meningitis is the most feared coccidioidomycosis complication. Nikkomycin Z (nikZ) is a chitin synthase inhibitor. A concern is short half-life, necessitating multiple dose/day regimens. We simulated extended release, providing nikZ in dri