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Publikováno v:
Biochemical and Biophysical Research Communications. 582:8-15
Gap junction beta 1 (GJB1) is the pathogenic gene of X-linked Charcot-Marie-Tooth type 1 (CMTX1), a rare hereditary sensorimotor neuropathy. However, different mutations of GJB1 result in heterogeneous clinical manifestations with only some mutations
Publikováno v:
Inflammation. 45:992-1006
Hyperglycemia-induced oxidative stress in podocytes exerts a major role in the pathological process of diabetic nephropathy. Tripartite motif-containing protein 32 (TRIM32) has been reported to be a key protein in the modulation of cellular apoptosis
Publikováno v:
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity, Vol 2021 (2021)
Oxidative Medicine and Cellular Longevity, Vol 2021 (2021)
Aerobic exercise mitigates oxidative stress and apoptosis caused by myocardial infarction (MI) even though the precise mechanisms remain completely elusive. In this study, we investigated the potential mechanisms of aerobic exercise in ameliorating t
Publikováno v:
Biochemical and Biophysical Research Communications. 580:7-13
Angiogenesis, the formation of new blood vessels from the pre-existing ones, is a hallmark characteristic of glioblastoma, making it an appealing target for treatment development. Given potent anti-cancer efficacy of mefloquine, FDA-approved anti-mal
Autor:
Zhuolin Li, Vivi Kasim, Yanjun Li, Guanbing Song, Juan Li, Makoto Miyagishi, Shourong Wu, Yuxin He, Hezhao Zhao
Publikováno v:
Oncogene. 40:6736-6747
Tumor metabolic reprogramming ensures that cancerous cells obtain sufficient building blocks, energy, and antioxidants to sustain rapid growth and for coping with oxidative stress. Neurogenic differentiation factor 1 (NeuroD1) is upregulated in vario
Publikováno v:
Journal of Cellular and Molecular Medicine
Emerging evidence indicates extensive oxidative stress is a consequence of obesity which impairs bone formation. Glutathione peroxidase 7 (GPX7) is a conserved endoplasmic reticulum (ER) retention protein, lacking of which causes accumulation of reac
Publikováno v:
Journal of Investigative Dermatology. 141:2354-2368
Cutaneous squamous cell carcinomas (SCCs) are frequent heterogeneous tumors arising from sun-exposed regions of the skin and characterized by complex pathogenesis. HOPX is a member of the homeodomain-containing superfamily of proteins holding an atyp
Autor:
Xianjun Zhu, Kuanxiang Sun, Jieping Wang, Junkai Tan, Wanli Tian, Bernie Fitzmaurice, Yeming Yang, Bo Chang, Xuyang Liu, Wenjing Liu, Patsy M. Nishina, Xiao Li
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-15 (2021)
Cell Death & Disease
Cell Death & Disease
Glaucoma is a leading cause of blindness, affecting 70 million people worldwide. Owing to the similarity in anatomy and physiology between human and mouse eyes and the ability to genetically manipulate mice, mouse models are an invaluable resource fo
Autor:
Yizhuo Wang, Ping Fu, Ling Li, Yijie Zhou, Liang Ma, Meng Zhao, Yanrong Lu, Rongshuang Huang, Shuyun Liu, Peng Lou, Jingping Liu, Chengshi Wang
Publikováno v:
Journal of Cellular and Molecular Medicine
Acute kidney injury (AKI) is a serious disease for which effective therapeutic agents are required. The capacity of curcumin (CUR) to resolve renal inflammation/oxidative stress and mitochondrial damage has been reported, but crosstalk between these
Publikováno v:
Journal of Cellular and Molecular Medicine
Nasopharyngeal carcinoma (NPC), a subclass of cancers of the neck and head, is a predominant cause of cancer‐associated death worldwide. Hence, there is a critical need for research into NPC‐related treatment strategies. Cisplatin is a promising