Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Xiaobin Han"'
Autor:
Xiaobin Han
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9789811380228
Taurine transporter (TauT) has been identified as a target gene of p53 tumor suppressor. TauT is also found to be overexpressed in variety type of human cancers, such as leukemia. This study showed that expression of TauT was upregulated by c-Myc and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ccae5c61b9b9462f021d369b1eaf577
https://doi.org/10.1007/978-981-13-8023-5_50
https://doi.org/10.1007/978-981-13-8023-5_50
Publikováno v:
Journal of the American Society of Nephrology. 20:1323-1332
Nephrotoxicity is common with the use of the chemotherapeutic agent cisplatin, but the cellular mechanisms that modulate the extent of injury are unknown. Cisplatin downregulates expression of the taurine transporter gene ( TauT ) in LLC-PK1 proximal
Autor:
Russell W. Chesney, Xiaobin Han, Stephen W. Schaffer, Takashi Ito, Junichi Azuma, Andrea B. Patters
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 1, p e0117718 (2015)
PLoS ONE, Vol 10, Iss 1, p e0117718 (2015)
Diabetic nephropathy is the leading cause of end stage renal disease in the world. Although tremendous efforts have been made, scientists have yet to identify an ideal animal model that can reproduce the characteristics of human diabetic nephropathy.
Publikováno v:
Journal of Biological Chemistry. 277:39266-39273
Taurine, an intracellular osmolyte whose body pool size is adaptively regulated by the kidney, is required for normal renal development. Overexpression of the p53 tumor suppressor gene in p53 transgenic mice results in renal malformation, suggesting
Autor:
Xiaobin Han, Russell W. Chesney
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781461460923
Studies have demonstrated that TauT deficiency results in small kidneys in TauT knockout mice. Our studies have shown that TauT is a direct target of several genes, including p53 and WT1, which play an important role in renal development. However, wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4556945546e1c62ecfbc6befa4ed6ab6
https://doi.org/10.1007/978-1-4614-6093-0_28
https://doi.org/10.1007/978-1-4614-6093-0_28
Autor:
Russell W. Chesney, Xiaobin Han
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781461460923
The interaction between taurine and the absorption of fat-soluble vitamins, such as vitamin A and D, has been an interesting topic in the field of nutrition science, because taurine-conjugated bile acid optimizes fat and fat-soluble vitamin absor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8f4455192745ee78d3da22713653667
https://doi.org/10.1007/978-1-4614-6093-0_27
https://doi.org/10.1007/978-1-4614-6093-0_27
Autor:
Xiaobin Han, Russell W. Chesney
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9780387756806
Acute renal failure (ARF) results from ischemic or toxic renal injury and is a common disorder with an overall mortality rate of about 50%. Despite the advent of dialysis and increasing knowledge regarding the causes and the effects of ARF, this tren
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7d7717f82f254b16c43c2bb4ea0934d
https://doi.org/10.1007/978-0-387-75681-3_11
https://doi.org/10.1007/978-0-387-75681-3_11
Publikováno v:
Acta physiologica (Oxford, England). 187(1-2)
Taurine transport undergoes an adaptive response to changes in taurine availability. Unlike most amino acids, taurine is not metabolized or incorporated into protein but remains free in the intracellular water. Most amino acids are reabsorbed at rate
Autor:
Russell W. Chesney, Xiaobin Han
Publikováno v:
Pediatric nephrology (Berlin, Germany). 20(8)
Cisplatin is a commonly used chemotherapeutic agent that has a major limitation because of its nephrotoxicity. Since cisplatin-induced renal injury is mainly confined to the S3 segment of renal proximal tubules-the primary site for renal adaptive reg
Autor:
Russell W. Chesney, Xiaobin Han
Publikováno v:
FEBS letters. 540(1-3)
In the present study we have demonstrated that WT1 (Wilms tumor suppressor gene) enhances the expression of TauT (taurine transporter gene) in human embryonic kidney 293 cells in a dose-dependent manner. TauT promoter activity was increased five-fold