Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Simon Lord"'
Publikováno v:
Drug Target Insights, Vol 6, Iss 1 (2012)
Abstract non disponibile
Externí odkaz:
https://doaj.org/article/16d9f057753a4d67b03a702c4015d7a6
Publikováno v:
Current Drug Targets. 17:1714-1727
Antiangiogenic resistance is a major problem in cancer therapeutics. Preclinical research has identified several compensatory proangiogenic pathways that arise upon vascular endothelial growth factor inhibition, several of which have led to the devel
Angiogenesis is integral to tumour growth and invasion, and is a key target for cancer therapeutics. However, for many of the licensed indications, only a modest clinical benefit has been observed for both monoclonal antibody and small-molecule tyros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cf9ee4f80cab8e4c5ef4f7ecf1d81fc
https://ora.ox.ac.uk/objects/uuid:c741b8dd-2eaf-45e4-8859-25dcfba295de
https://ora.ox.ac.uk/objects/uuid:c741b8dd-2eaf-45e4-8859-25dcfba295de
Publikováno v:
Experimental Cell Research. 318:1586-1596
Several epidemiological studies have indicated that abundant consumption of foods from plant origin is associated with a reduced risk of developing several types of cancers. This chemopreventive effect is related to the high content of these foods in
Publikováno v:
Bio tribune magazine. 38:39-45
Recent profiling has identified the aminopeptidase N/CD13 inhibitor actinonin as a selective soluble secreted matrix metalloproteinase (MMP) inhibitor. Given that actinonin’s effects against membranebound MMPs remain unknown and that MT1-MMP has be
Publikováno v:
Chemical Biology & Drug Design. 75:481-488
Tahanian E, Lord-Dufour S, Das A, Khosla C, Roy R, Annabi B. A better understanding of the metabolic adaptations of the vascular endothelial cells (EC) that mediate tumor vascularization would help the development of new drugs and therapies. Novel ro
Publikováno v:
Cancer Letters. 279:171-176
Recent profiling has identified the aminopeptidase N/CD13 inhibitor actinonin as a selective soluble secreted matrix metalloproteinase (MMP) inhibitor. Given that actinonin's effects against membrane-bound MMPs remain unknown and that MT1-MMP has bee
Publikováno v:
Vascular pharmacology. 53(5-6)
Propranolol, a non-selective β-adrenergic blocking drug, was recently reported to control the growth of hemangiomas, the most common vascular tumor of infancy. However, the mechanisms involved in this effect remain unknown. Here, we demonstrate that
Autor:
Simon Lord, Adrian L. Harris
Publikováno v:
Breast Cancer Research : BCR
Mechanisms of resistance to anti-angiogenic therapy Several mechanisms for intrinsic and acquired tumour resistance to anti-angiogenic therapy have now been proposed. It is now clear that revascularisation can occur after the inhibition of VEGF signa
Autor:
Jacques Galipeau, Simon Lord-Dufour, Jessica Cuerquis, Daniel L. Coutu, Ian B. Copland, Borhane Annabi, Eugenea Wang
Publikováno v:
Stem cells (Dayton, Ohio). 27(2)
Mesenchymal stromal cells (MSCs) display robust reparative properties through their ability to limit apoptosis, enhance angiogenesis, and direct positive tissue remodeling. However, low in vivo survival of transplanted cells limits their overall effe