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Autor:
Murray B. Stein, Thomas D. Geracioti, Cristine Cusin, Xiaoying Sun, Rema Raman, Gail M. Farfel, Jennifer C. Naylor, Christine E. Marx, James B. Lohr, Julia Tsai, Ariel J. Lang, Mark B. Hamner, Ann M. Rasmusson, Sonia Jain, Lanier Summerall, Richard B. Rosse
Publikováno v:
Psychopharmacology. 234:2245-2257
Preclinical and clinical research supports a role for neuroactive steroids in the pathophysiology of posttraumatic stress disorder (PTSD). We investigated ganaxolone (a synthetic 3β-methylated derivative of allopregnanolone, a GABAergic neuroactive
Autor:
C. Warren Olanow, Karl Kieburtz, Mika Leinonen, Lawrence Elmer, Nir Giladi, Robert A. Hauser, Olga S. Klepiskaya, David L. Kreitzman, Mark F. Lew, David S. Russell, Shaul Kadosh, Pninit Litman, Hadas Friedman, Nurit Linvah, for the PB Study Group
Publikováno v:
Movement Disorders. 32:783-789
Background Rasagiline and pramipexole act to improve striatal dopaminergic transmission in PD via distinct and potentially synergistic mechanisms. We performed a placebo-controlled study to determine whether 2 doses of a novel slow-release, low-dose
Publikováno v:
Psychopharmacology. 233:2869-2877
‘Piperazine-containing party pills’ were marketed and sold as legal alternatives to methamphetamine and 3,4-methylenedioxymethamphetamine (MDMA) until 2008 in New Zealand. The major constituents of these ‘pills’ were benzylphenylpiperazine (B
Autor:
Joseph P. McEvoy, Leslie Citrome
Publikováno v:
Clinical Schizophrenia & Related Psychoses. 9:177-186
Brexpiprazole is an antipsychotic medication and received approval by the U.S. Food and Drug Administration for the treatment of schizophrenia in July 2015. Brexpiprazole acts as a partial agonist at dopamine D2 and serotonin 5-HT1A receptors, and as
Autor:
Michael R. Wierzbicki, William D. Dundon, Kevin G. Lynch, Charles P. O'Brien, Helen M. Pettinati, Kyle M. Kampman, Elizabeth M. Mahoney
Publikováno v:
The American Journal on Addictions. 23:591-597
Background There is a high co-occurrence of cocaine and alcohol use disorders, and patients with both of these problems are difficult to treat. There is a reasonable rationale and some empirical data to justify a pilot trial of an injectable, extende
Autor:
Rosa Magallón, Laura Viguera, Javier García-Campayo, Eva Andrés, Paola Herrera-Mercadal, Bárbara Oliván-Blázquez, Yolanda López del Hoyo, Nicolás Fayed, Marta Puebla-Guedea, Mari-Cruz Pérez-Yus
Publikováno v:
CNS Neuroscience & Therapeutics. 20:999-1007
Summary Aim To evaluate the efficacy of memantine on metabolite levels in different areas of the brain and to determine whether changes in metabolite levels correlate with clinical variables in Fibromyalgia (FM) patients. Methods Doubled-blind parall
Publikováno v:
Movement Disorders. 29:1028-1034
Dopamine agonists (DA) are often used as first-line monotherapy for the symptomatic control of Parkinson's disease (PD). However, DA monotherapy typically becomes inadequate within a few years, at which time the DA dosage must be increased or other a
Autor:
Cynthia L. Vuittonet, Carolina L. Haass-Koffler, Samuel R. Fricchione, Lorenzo Leggio, Michael Brickley, Robert M. Swift, James S. Clifford, William H. Zywiak, John E. McGeary, Jessica R. Shoaff, Kayla Beaucage, George A. Kenna
Publikováno v:
Alcoholism: Clinical and Experimental Research. 38:1567-1574
Background One hypothesis suggests that the differential response to ondansetron- and serotonin-specific re-uptake inhibitors (SSRIs) may be due to a functional polymorphism of the 5′-HTTLPR promoter region in SLC6A4, the gene that codes for the se
Autor:
Román Valiente, Consuelo García-Gea, Joan Martínez, Ignasi Gich, Maria Ballester, Rosa M. Antonijoan
Publikováno v:
Human Psychopharmacology: Clinical and Experimental. 29:120-132
Objective The aim of this study was to compare the effects of concomitant administration of alcohol and bilastine versus alcohol alone on the central nervous system. Methods Twenty-four healthy young volunteers of both sexes participated in a randomi
Autor:
Joseph Gao, M. Celeste Ferreira-Cornwell, Patricia Donnelly, Gary Zammit, Thomas Roth, Jon Freeman, Maria Gasior
Publikováno v:
Journal of Clinical Psychopharmacology. 34:642-644
In a study of acute sleep deprivation in healthy male volunteers randomized to double-blind treatment with lisdexamfetamine dimesylate (20, 50, or 70 mg), placebo control, or an active control (armodafinil 250 mg), Maintenance of Wakefulness Test dat