Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Robert F. Paulson"'
Publikováno v:
Blood. 132:2580-2593
Anemic stress induces a physiological response that includes the rapid production of new erythrocytes. This process is referred to as stress erythropoiesis. It is best understood in the mouse where it is extramedullary and utilizes signals and progen
Selenium (Se) is incorporated as the 21(st) amino acid selenocysteine (Sec) into the growing polypeptide chain of proteins involved in redox gatekeeper functions. Erythropoiesis presents a particular problem to redox regulation as the presence of iro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdefb2e77f9d90e215c2d37d2c809945
https://europepmc.org/articles/PMC6168382/
https://europepmc.org/articles/PMC6168382/
Autor:
Joshua J. Coon, Nobuyuki Tanimura, Koichi R. Katsumura, Daniel R. Matson, Kyle J. Hewitt, Emery H. Bresnick, Prithvia Devadas, Sunduz Keles, Alexander S. Hebert, Siyang Hao, Jin-Soo Kim, Colin N. Dewey, Robert F. Paulson
An enhancer with amalgamated E-box and GATA motifs (+9.5) controls expression of the regulator of hematopoiesis GATA-2. While similar GATA-2-occupied elements are common in the genome, occupancy does not predict function, and GATA-2-dependent genetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7bb662254d2c3bd7437d4e7b3f978dd
https://europepmc.org/articles/PMC5578808/
https://europepmc.org/articles/PMC5578808/
Autor:
Bradley A. Carlson, Mary J. Kennett, K. Sandeep Prabhu, Chang Liao, Robert F. Paulson, Ross C. Hardison
Publikováno v:
Blood. 131(23)
Micronutrient selenium (Se) plays a key role in redox regulation through its incorporation into selenoproteins as the 21st amino acid selenocysteine (Sec). Because Se deficiency appears to be a cofactor in the anemia associated with chronic inflammat
Publikováno v:
Experimental Hematology. 37:549-558
Objective In mice, homeostatic erythropoiesis occurs primarily in the bone marrow. However, in response to acute anemia, bone morphogenetic proteins 4 (BMP-4)−dependent stress erythropoiesis occurs in the adult spleen. BMP-4 can also regulate stres
Autor:
Omid F. Harandi, Arun Kannan, Prashanth Porayette, Shailaja Hegde, John M. Perry, Robert F. Paulson
Publikováno v:
Blood. 113:911-918
The production of mature cells necessitates that lineage-committed progenitor cells be constantly generated from multipotential progenitors. In addition, the ability to respond rapidly to physiologic stresses requires that the signals that regulate t
Publikováno v:
Experimental Hematology. 37:10-18
Objective Podocalyxin expression on Ter119 + erythroblasts is induced following administration of erythropoietin (Epo) or phenylhydrazine treatment, but is notably absent on committed erythroid progenitors during homeostatic red cell turnover. Follow
Publikováno v:
Blood. 125(11)
Tissue hypoxia induces a systemic response designed to increase oxygen delivery to tissues. One component of this response is increased erythropoiesis. Steady-state erythropoiesis is primarily homeostatic, producing new erythrocytes to replace old er
Autor:
Robert F. Paulson
Publikováno v:
Nature Medicine. 17:1346-1348
Although erythropoietin (Epo) is commonly used as a therapy for anemia, recent studies have suggested that Epo therapy is associated with adverse outcomes. A new study shows that polymeric IgA1 positively regulates erythropoiesis through binding to t
Publikováno v:
Nature Genetics. 13:309-315
Protein tyrosine phosphorylation plays a key role in regulating eukaryotic cell proliferation and differentiation. Genetic analysis in invertebrates has been invaluable for dissecting the signalling events downstream of receptor tyrosine kinases (RTK