Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Susan S. Margulies"'
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0237613 (2020)
PLoS ONE
PLoS ONE
Background Nordihydroguaiaretic acid (NDGA) is a plant extract that has been shown to act as a free radical scavenger and pluripotent inhibitor of pro-inflammatory cytokines, two major cellular processes involved in the pathophysiology of sepsis. We
Publikováno v:
J Mech Behav Biomed Mater
When the head is rotated rapidly, the movement of the brain lags that of the skull. Intracranial contents between the brain and skull include meninges, cerebrospinal fluid (CSF), and cerebral vasculature. Among the cerebral vasculature in this space
Autor:
Susan S. Margulies, David Gabrieli, Jongho Lee, Stephanie A. Eucker, Colin Smith, Brittany Coats, Connor Bradfield, Sarah Sullivan, Matthew R. Maltese
Publikováno v:
Biomechanics and Modeling in Mechanobiology. 14:877-896
A systematic correlation between finite element models (FEMs) and histopathology is needed to define deformation thresholds associated with traumatic brain injury (TBI). In this study, a FEM of a transected piglet brain was used to reverse engineer t
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 304:L210-L220
Simulating ventilator-induced lung injury (VILI) in the laboratory requires stretching of lung alveolar tissue. Whereas precision-cut lung slices (PCLSs) are widely used for studying paracrine signaling pathways in the lungs, their use in stretch stu
Autor:
Matthew R. Maltese, Susan S. Margulies
The finite element (FE) brain model is used increasingly as a design tool for developing technology to mitigate traumatic brain injury. We developed an ultra high-definition FE brain model (>4 million elements) from CT and MRI scans of a 2-month-old
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da16bde5722b689deec0d05d5f7ac459
https://europepmc.org/articles/PMC4996718/
https://europepmc.org/articles/PMC4996718/
Autor:
Brittany Coats, Susan S. Margulies
Publikováno v:
Journal of Biomechanics. 39:2521-2525
Computational models of the head can be used to simulate events associated with traumatic brain injury and to design protective equipment and environments. Accurate material property descriptions of biological tissues are crucial to the development o
Publikováno v:
Journal of Biomechanical Engineering. 127:512-524
Pressure sores (PS) in deep muscles are potentially fatal and are considered one of the most costly complications in spinal cord injury patients. We hypothesize that continuous compression of the longissimus and gluteus muscles by the sacral and isch
Publikováno v:
Journal of Neurotrauma. 20:1163-1177
Clinical and biomechanical evidence indicates that mechanisms and pathology of head injury in infants and young children may be different from those in adults. Biomechanical computer-based modeling, which can be used to provide insight into the thres
Autor:
Ramesh Raghupathi, Susan S. Margulies
Publikováno v:
Journal of Neurotrauma. 19:843-853
Closed head injury is the leading cause of morbidity and mortality in infants and children, and results in pathologies such as diffuse axonal injury (DAI) and subarachnoid hematoma (SAH). To better understand the mechanical environment associated wit
Autor:
Susan S. Margulies, Allan I. Pack, Michael J. Brennick, Luke Hiller, Malcolm D. Ogilvie, Warren B. Gefter
Publikováno v:
Journal of Applied Physiology. 85:1884-1897
Upper airway compliance indicates the potential of the airway to collapse and is relevant to the pathogenesis of obstructive sleep apnea. We hypothesized that compliance would vary over the rostral-to-caudal extent of the pharyngeal airway. In a para