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pro vyhledávání: '"Susan S. Margulies"'
Autor:
Susan S. Margulies, David Gabrieli, Jongho Lee, Stephanie A. Eucker, Colin Smith, Brittany Coats, Connor Bradfield, Sarah Sullivan, Matthew R. Maltese
Publikováno v:
Biomechanics and Modeling in Mechanobiology. 14:877-896
A systematic correlation between finite element models (FEMs) and histopathology is needed to define deformation thresholds associated with traumatic brain injury (TBI). In this study, a FEM of a transected piglet brain was used to reverse engineer t
Autor:
Ramesh Raghupathi, Susan S. Margulies
Publikováno v:
Journal of Neurotrauma. 19:843-853
Closed head injury is the leading cause of morbidity and mortality in infants and children, and results in pathologies such as diffuse axonal injury (DAI) and subarachnoid hematoma (SAH). To better understand the mechanical environment associated wit
Publikováno v:
Eucker, S A, Smith, C, Ralston, J, Friess, S H & Margulies, S S 2011, ' Physiological and histopathological responses following closed rotational head injury depend on direction of head motion ', Experimental neurology, vol. 227, no. 1, pp. 79-88 . https://doi.org/10.1016/j.expneurol.2010.09.015
Rotational inertial forces are thought to be the underlying mechanism for most severe brain injuries. However, little is known about the effect of head rotation direction on injury outcomes, particularly in the pediatric population. Neonatal piglets
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6cd3322a306d2d01e9f1d2491c6c40b
https://europepmc.org/articles/PMC3021173/
https://europepmc.org/articles/PMC3021173/
Autor:
Susan S. Margulies, Kirk L. Thibault
Publikováno v:
Journal of biomechanics. 31(12)
During growth and development, the immature central nervous system undergoes rapid alterations in constituents and structure. We hypothesize that these alterations are accompanied by changes in the mechanical properties of brain tissue which, in turn