Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Koji Abe"'
Autor:
Toru Yamashita, Koji Abe
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 5, p 2945 (2024)
The brain is susceptible to oxidative stress, which is associated with various neurological diseases. Edaravone (MCI-186, 3-methyl-1 pheny-2-pyrazolin-5-one), a free radical scavenger, has promising effects by quenching hydroxyl radicals (∙OH) and
Externí odkaz:
https://doaj.org/article/c6ed3eed92844d33b867697294bb47d2
Autor:
Hisashi Narai, Yasuhiro Manabe, Makiko Nagai, Isao Nagano, Yasuyuki Ohta, Tetsuro Murakami, Yasushi Takehisa, Tatsushi Kamiya, Koji Abe
Publikováno v:
Neurology International, Vol 1, Iss 1, Pp e16-e16 (2009)
The transgenic animals with mutant copper/zinc superoxide dismutase (SOD1) DNA develop paralytic motor neuron disease resembling human amyotrophic lateral sclerosis (ALS) patients and are commonly used as models for ALS. In the transgenic (Tg) mice w
Externí odkaz:
https://doaj.org/article/8ed210a4e1e740968c5300252911c1c9
Autor:
Mami Takemoto, Emi Nomura, Koh Tadokoro, Yoshio Omote, Toru Yamashita, Yasuyuki Ohta, Koji Abe, Ryuta Morihara, Jingwei Shang
Publikováno v:
Neuroscience. 466:47-57
The degradation of damaged proteins takes place via two major proteolytic pathways: the ubiquitin–proteasome system (UPS) and autophagy. However, since it is unclear how these two proteolytic pathways contribute to the pathogenesis of amyotrophic l
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2525
Oxidative and hypoxic stresses are associated with the degeneration of both motor neurons and skeletal muscles in amyotrophic lateral sclerosis (ALS). In vivo bioluminescent imaging is used to monitor cellular responses to oxidative and hypoxic stres
Autor:
Mami Takemoto, Kota Sato, Koji Abe, Yasuyuki Ohta, Nozomi Hishikawa, Takashi Tamiya, Yusuke Fukui, Toru Yamashita, Tetsuhiro Hatakeyama, Nobuyuki Kawai, Yoshihiro Nishiyama
Publikováno v:
Neurological Research. 43:429-433
Objective: Amyotrophic lateral sclerosis (ALS) is a progressive and fatal motor neuron disease. Hypoxic stress is suspected as the pathogenesis of ALS, however, no positron emission tomography (PET...
Autor:
Mami Takemoto, Emi Nomura, Koh Tadokoro, Yoshio Omote, Mari Dezawa, Koji Abe, Toru Yamashita, Yoshihiro Kushida, Shohei Wakao, Yasuyuki Ohta, Nozomi Hishikawa
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-3 (2021)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Autor:
Toru Yamashita, Yumiko Nakano, Ryo Sasaki, Koh Tadokoro, Yoshio Omote, Taijun Yunoki, Yuko Kawahara, Namiko Matsumoto, Yuki Taira, Chika Matsuoka, Ryuta Morihara, Koji Abe
Publikováno v:
Cell Transplantation; Jan-Dec2023, Vol. 32, p1-9, 9p
Autor:
Keiichiro Tsunoda, Xiaowen Shi, Jingwei Shang, Toru Yamashita, Kota Sato, Mami Takemoto, Koji Abe, Yasuyuki Ohta, Namiko Matsumoto, Tian Feng, Nozomi Hishikawa, Xia Liu, Takahiro Kuchimaru, Ryo Sasaki, Emi Nomura, Koh Tadokoro, Shinae Kizaka-Kondoh
Publikováno v:
Neuroscience. 415:31-43
Hypoxia inducible factor-1α (HIF-1α) is a key transcription factor that maintains oxygen homeostasis. Hypoxic stress is related to the pathogenesis of amyotrophic lateral sclerosis (ALS), and impaired HIF-1α induces motor neuron degeneration in AL
Autor:
Kiwamu Matsuoka, Ken Ikegami, Hitoshi Shimada, Nozomi Hishikawa, Makoto Higuchi, Koji Abe, Yasuyuki Ohta, Kenji Tagai, Mami Takemoto, Yoshio Omote, Toru Yamashita, Keiichiro Tsunoda
Publikováno v:
Neurology and Clinical Neuroscience. 9:124-126
Autor:
Genki Tohnai, Ryoichi Nakamura, Naoki Atsuta, Masahiro Nakatochi, Naoki Hayashi, Daisuke Ito, Hazuki Watanabe, Hirohisa Watanabe, Masahisa Katsuno, Yuishin Izumi, Akira Taniguchi, Kazuaki Kanai, Mitsuya Morita, Osamu Kano, Satoshi Kuwabara, Masaya Oda, Koji Abe, Masashi Aoki, Ikuko Aiba, Koichi Okamoto, Kouichi Mizoguchi, Tomohiko Ishihara, Akihiro Kawata, Takanori Yokota, Kazuko Hasegawa, Isao Nagano, Ichiro Yabe, Fumiaki Tanaka, Satoshi Kuru, Nobutaka Hattori, Kenji Nakashima, Ryuji Kaji, Gen Sobue
Publikováno v:
Neurobiology of aging. 113
DNAJC7 has recently been identified as an amyotrophic lateral sclerosis (ALS) gene via large-scale exome analysis, and its involvement in ALS is still unclear in various populations. This study aimed to determine the frequencies and characteristics o