Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Guillaume Cognet"'
Autor:
Marie Sabatier, Emeline Boet, Sonia Zaghdoudi, Nathan Guiraud, Alexis Hucteau, Nathaniel Polley, Guillaume Cognet, Estelle Saland, Laura Lauture, Thomas Farge, Ambrine Sahal, Vera Pancaldi, Emeline Chu-Van, Florence Castelli, Sarah Bertoli, Pierre Bories, Christian Récher, Héléna Boutzen, Véronique Mansat-De Mas, Lucille Stuani, Jean-Emmanuel Sarry
Publikováno v:
Cancers, Vol 13, Iss 20, p 5243 (2021)
Relapses and resistance to therapeutic agents are major barriers in the treatment of acute myeloid leukemia (AML) patients. These unfavorable outcomes emphasize the need for new strategies targeting drug-resistant cells. As IDH mutations are present
Externí odkaz:
https://doaj.org/article/fb95b200b1954d7c9209a40ae5528062
Autor:
Pierre Bories, Sonia Zaghdoudi, Jean-Emmanuel Sarry, Florence Castelli, Héléna Boutzen, Alexis Hucteau, Sarah Bertoli, Marie Sabatier, Ambrine Sahal, Laura Lauture, Thomas Farge, Vera Pancaldi, Emeline Chu-Van, Lucille Stuani, Emeline Boet, Nathaniel Polley, Christian Récher, Nathan Guiraud, Guillaume Cognet, Estelle Saland, Véronique Mansat-De Mas
Publikováno v:
Cancers
Volume 13
Issue 20
Cancers, Vol 13, Iss 5243, p 5243 (2021)
Volume 13
Issue 20
Cancers, Vol 13, Iss 5243, p 5243 (2021)
Simple Summary Around 15% of acute myeloid leukemia (AML) patients harbor mutations in isocitrate dehydrogenases (IDH), which lead to the production of the oncometabolite 2-hydroxyglutarate (2-HG). Inhibitors of mutant IDH enzymes and their 2-HG prod