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pro vyhledávání: '"Nicholas J. Agard"'
Autor:
Kenichi Shimada, Arnold L. Rheingold, Kazutaka Shimbo, Nicholas J. Agard, Vincent J. Venditto, Olivier Julien, Jonathan S. Weissman, Brent R. Stockwell, Julie A. Zorn, Michael C. Bassik, James A. Wells, Martin Kampmann
Publikováno v:
Nature chemical biology
We previously discovered a small-molecule inducer of cell death, named 1541, that noncovalently self-assembles into chemical fibrils ('chemi-fibrils') and activates procaspase-3 in vitro. We report here that 1541-induced cell death is caused by the f
Autor:
Aenoch J. Lynn, Nicholas J. Agard, Sami Mahrus, James A. Wells, Jonathan C. Trinidad, Alma L. Burlingame
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 109(6)
Mass spectrometry-based proteomics is a powerful tool for identifying hundreds to thousands of posttranslational modifications in complex mixtures. However, it remains enormously challenging to simultaneously assess the intrinsic catalytic efficienci
Publikováno v:
Molecularcellular proteomics : MCP. 9(5)
The inflammatory caspases, human caspases-1, -4, and -5, proteolytically modulate diverse physiological outcomes in response to proinflammatory signals. Surprisingly, only a few substrates are known for these enzymes, including other caspases and the