Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Catherine L. Drennan"'
Autor:
Sarah E. J. Bowman, Lindsey R. F. Backman, Rebekah E. Bjork, Mary C. Andorfer, Santiago Yori, Alessio Caruso, Collin M. Stultz, Catherine L. Drennan
Publikováno v:
PMC
J Biol Inorg Chem
J Biol Inorg Chem
Glycyl radical enzymes (GREs) utilize a glycyl radical cofactor to carry out a diverse array of chemically challenging enzymatic reactions in anaerobic bacteria. Although the glycyl radical is a powerful catalyst, it is also oxygen sensitive such tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7d80c3d19a7f863e84697336fe954fe
https://hdl.handle.net/1721.1/129986
https://hdl.handle.net/1721.1/129986
Autor:
Masaki Horitani, Eric M. Shepard, Ashley Rasmussen, Kaitlin S. Duschene, Adam V. Crain, Rachel U. Hutcheson, Catherine L. Drennan, Amanda S. Byer, Jessica L. Vey, Jian Yang, Krista A. Shisler, William E. Broderick, Joan B. Broderick, Brian M. Hoffman
Publikováno v:
Journal of the American Chemical Society
Pyruvate formate-lyase activating enzyme (PFL-AE) is a radical S-adenosyl-l-methionine (SAM) enzyme that installs a catalytically essential glycyl radical on pyruvate formate-lyase. We show that PFL-AE binds a catalytically essential monovalent catio
Autor:
Daniel P. Dowling, Christopher T. Walsh, Catherine L. Drennan, Yan Kung, Anna K. Croft, Wendy L. Kelly, Koli Taghizadeh
Epothilones are thiazole-containing natural products with anticancer activity that are biosynthesized by polyketide synthase (PKS)-nonribosomal peptide synthetase (NRPS) enzymes EpoA-F. A cyclization domain of EpoB (Cy) assembles the thiazole functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99deadb1763ae8fffb5ebbcfc7bc04ed
https://nottingham-repository.worktribe.com/file/823124/1/EpoBcy-V11-PNAS_deposition.pdf
https://nottingham-repository.worktribe.com/file/823124/1/EpoBcy-V11-PNAS_deposition.pdf
Autor:
Colin D. Douglas, Andrew M. Sydor, Catherine L. Drennan, Katherine S. Ryan, Kaitlyn E. Turo, Deborah B. Zamble, Marco Jost
Publikováno v:
Biochemistry
GTPases are critical molecular switches involved in a wide range of biological functions. Recent phylogenetic and genomic analyses of the large, mostly uncharacterized COG0523 subfamily of GTPases revealed a link between some COG0523 proteins and met
Publikováno v:
The Journal of Physical Chemistry. B
The potential exploitation of metal-reducing bacteria as a means for environmental cleanup or alternative fuel is an exciting prospect; however, the cellular processes that would allow for these applications need to be better understood. MtrA is a pe
Autor:
Catherine L. Drennan, Jessica L. Vey
Publikováno v:
Chemical Reviews. 111:2487-2506
Publikováno v:
Journal of the American Chemical Society
CytC3, a member of the recently discovered class of nonheme Fe(II) and alpha-ketoglutarate (alphaKG)-dependent halogenases, catalyzes the double chlorination of L-2-aminobutyric acid (Aba) to produce a known Streptomyces antibiotic, gamma,gamma-dichl
Publikováno v:
Nature Reviews Microbiology. 5:710-720
The ribbon-helix-helix (RHH) superfamily of transcription factors uses a conserved three-dimensional structural motif to bind to DNA in a sequence-specific manner. This functionally diverse protein superfamily regulates the transcription of genes tha
Acyl-CoA mutases are a growing class of adenosylcobalamin-dependent radical enzymes that perform challenging carbon skeleton rearrangements in primary and secondary metabolism. Members of this class of enzymes must precisely control substrate positio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b02ce1242a1d8f0488908f5f75d3bc6
https://europepmc.org/articles/PMC4646380/
https://europepmc.org/articles/PMC4646380/
Autor:
Jésus Fernández-Zapata, Subramanian Padmanabhan, Juan Manuel Ortiz-Guerrero, Percival Yang-Ting Chen, Gyunghoon Kang, María Carmen Polanco, Marco Jost, Catherine L. Drennan, Montserrat Elías-Arnanz
Publikováno v:
Nature
PMC
Digital.CSIC. Repositorio Institucional del CSIC
instname
PMC
Digital.CSIC. Repositorio Institucional del CSIC
instname
Photoreceptor proteins enable organisms to sense and respond to light. The newly discovered CarH-type photoreceptors use a Vitamin B derivative, adenosylcobalamin, as the light-sensing chromophore to mediate light-dependent gene regulation. Here we p