Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Weihong Song"'
Autor:
Man Luo, Yayan Pang, Junjie Li, Lilin Yi, Bin Wu, Qiuyun Tian, Yan He, Maoju Wang, Lei Xia, Guiqiong He, Weihong Song, Yehong Du, Zhifang Dong
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 2, Pp 635-652 (2024)
Alzheimer's disease (AD) is a leading cause of dementia in the elderly. Mitogen-activated protein kinase phosphatase 1 (MKP-1) plays a neuroprotective role in AD. However, the molecular mechanisms underlying the effects of MKP-1 on AD have not been e
Externí odkaz:
https://doaj.org/article/3c74df04a92a4e7c9d31b5922b70dbad
Publikováno v:
Translational Neurodegeneration, Vol 11, Iss 1, Pp 1-34 (2022)
Abstract Synaptic abnormalities are a cardinal feature of Alzheimer’s disease (AD) that are known to arise as the disease progresses. A growing body of evidence suggests that pathological alterations to neuronal circuits and synapses may provide a
Externí odkaz:
https://doaj.org/article/43a621d501e248dfa292790df1586ffe
Publikováno v:
Alzheimer’s Research & Therapy, Vol 11, Iss 1, Pp 1-12 (2019)
Abstract Background Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine. Chronic inflammation induced by amyloid β proteins (Aβ) is one prominent neuropathological feature in Alzheimer’s disease (AD) brain. Methods Elisa,
Externí odkaz:
https://doaj.org/article/80f67bb6ca7b46c3abbbc32040d8a2b2
Publikováno v:
Molecular Brain, Vol 12, Iss 1, Pp 1-10 (2019)
Abstract TMP21, a type I transmembrane protein of thep24 protein family, mediates protein trafficking and maturation. Dysregulation of TMP21 is implicated in the pathogenesis of Alzheimer’s disease (AD). However, underlying mechanisms remain elusiv
Externí odkaz:
https://doaj.org/article/b9990ce2c595402e833819d563fc9a17
Autor:
Zhilin Huang, Tao Tan, Yehong Du, Long Chen, Min Fu, Yanzhi Yu, Lu Zhang, Weihong Song, Zhifang Dong
Publikováno v:
Frontiers in Aging Neuroscience, Vol 9 (2017)
Alzheimer’s disease (AD) is a chronic neurodegenerative disease leading to dementia, which is characterized by progressive memory loss and other cognitive dysfunctions. Recent studies have attested that noninvasive repetitive transcranial magnetic
Externí odkaz:
https://doaj.org/article/dc8f2c4b5c104951adc6dcd93293a0b2
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 10 (2017)
Alzheimer’s disease (AD), the most common neurodegenerative disorder, is the leading cause of dementia. Neuritic plaque, one of the major characteristics of AD neuropathology, mainly consists of amyloid β (Aβ) protein. Aβ is derived from amyloid
Externí odkaz:
https://doaj.org/article/c90d3b7253d744279c3ed8665798ce10
Autor:
Qing Zhang, Weihong Song
Publikováno v:
MedComm
Coronavirus disease 2019 (COVID‐19) is an infectious disease that since its outbreak in December 2019 has become a global pandemic. COVID‐19 is caused by the previously unknown coronavirus SARS‐CoV‐2. The elderly are the most vulnerable to CO
Autor:
Lu Shen, Tahereh Bozorgmehr, Daochao Huang, Jifeng Guo, Yili Wu, Catharine H. Rankin, Si Zhang, Beisha Tang, Zhe Wang, Fang Cai, Weihong Song, Shuting Zhang
Publikováno v:
Molecular Psychiatry. 25:603-613
Presenilin-1 (PSEN1) is the catalytic subunit of the γ-secretase complex, and pathogenic mutations in the PSEN1 gene account for the majority cases of familial AD (FAD). FAD-associated mutant PSEN1 proteins have been shown to affect APP processing a
Autor:
Brian Giunta, Hao-Lun Sun, Xin-Fu Zhou, Zhang K, Zhifang Dong, Xiang Y, Jun Tan, Lin-Lin Shen, Xiaowei Chen, Shan Yc, Zhen-Qian Zhuang, Hua-Dong Zhou, Jun Wang, Yu-Hui Liu, Fan Zeng, Jiewei Liu, Xian-Le Bu, Ye-Ran Wang, Jin Ws, Xiu-Qing Yao, Huang Zl, Si-Han Chen, Weihong Song
Publikováno v:
Molecular Psychiatry. 23:1948-1956
The amyloid-β protein (Aβ) protein plays a pivotal role in the pathogenesis of Alzheimer’s disease (AD). It is believed that Aβ deposited in the brain originates from the brain tissue itself. However, Aβ is generated in both brain and periphera
Autor:
Zhilin Huang, Zhian Hu, Wang-Sheng Jin, Jia-Xiang Xiong, Weihong Song, Wei-Wei Zhang, Yan-Jiang Wang, Xin-Fu Zhou, Ya-Ni He, Zhifang Dong, Chang-Yue Gao, Lin-Lin Shen, Si-Han Chen, Yi-Zheng Wang, Xian-Le Bu, Hua-Dong Zhou
Publikováno v:
Acta Neuropathologica. 134:207-220
Clearance of amyloid-beta (Aβ) from the brain is an important therapeutic strategy for Alzheimer’s disease (AD). Current studies mainly focus on the central approach of Aβ clearance by introducing therapeutic agents into the brain. In a previous