Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Lutz, Frölich"'
Autor:
Shahzad Ahmad, Wei Yang, Adelina Orellana, Lutz Frölich, Itziar de Rojas, Amanda Cano, Mercè Boada, Isabel Hernández, Lucrezia Hausner, Amy C. Harms, Margot H. M. Bakker, Alfredo Cabrera-Socorro, Najaf Amin, Alfredo Ramírez, Agustín Ruiz, Cornelia M. Van Duijn, Thomas Hankemeier
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-13 (2024)
Abstract Background Isoprostanes and prostaglandins are biomarkers for oxidative stress and inflammation. Their role in Alzheimer's disease (AD) pathophysiology is yet unknown. In the current study, we aim to identify the association of isoprostanes
Externí odkaz:
https://doaj.org/article/43de45b042744c0e9c80620804e9b560
Autor:
Prof. Dr. med. Dipl.-Phys. Matthias Riepe, Prof. Dr. med. Lutz Frölich, Dr. theol. h.c. Jürgen Gohde, Dr. med. Harald Herholz MPH, Prof. Dr. med. Frank Jessen, Prof. Dr. rer.pol. h.c. Herbert Rebscher, Dr. med. Jürgen Bausch
Publikováno v:
Monitor Versorgungsforschung, Vol 2023, Iss 03, Pp 55-61 (2023)
Um die öffentliche Diskussion zu grundlegenden Themen hinsichtlich Diagnostik, Therapie und Versorgung von Demenz-patient:innen zu etablieren, die konkreten Handlungsbedarf aufzeigen, hat sich zu Beginn des Jahres 2020 das „Interdisziplinäre Di
Externí odkaz:
https://doaj.org/article/9b1e14e9c4744bf7b0c3dd5d53964216
Autor:
Shahzad Ahmad, Adelina Orellana, Isabelle Kohler, Lutz Frölich, Itziar de Rojas, Silvia Gil, Mercè Boada, Isabel Hernández, Lucrezia Hausner, Margot H. M. Bakker, Alfredo Cabrera-Socorro, Najaf Amin, Alfredo Ramírez, Agustín Ruiz, Thomas Hankemeier, Cornelia M. Van Duijn
Publikováno v:
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-13 (2020)
Abstract Background Lysophosphatidic acids (LPAs) are bioactive signaling phospholipids that have been implicated in Alzheimer’s disease (AD). It is largely unknown whether LPAs are associated with AD pathology and progression from mild cognitive i
Externí odkaz:
https://doaj.org/article/ac7c9027ac5f4c9bbafbd9c37495b270
Autor:
Anna-Sophia Wahl, Martin Löffler, Lucrezia Hausner, Michaela Ruttorf, Frauke Nees, Lutz Frölich
Publikováno v:
BMC Psychiatry, Vol 19, Iss 1, Pp 1-12 (2019)
Abstract Background Intracranial arachnoid cysts are usually benign congenital findings of neuroimaging modalities, sometimes however, leading to focal neurological and psychiatric comorbidities. Whether primarily clinically silent cysts may become c
Externí odkaz:
https://doaj.org/article/d58707ed5a6f4a33abc898415459a5bc
Publikováno v:
Alzheimer’s Research & Therapy, Vol 11, Iss 1, Pp 1-11 (2019)
Abstract Background There are currently no approved treatments for the prodromal stage of Alzheimer’s disease (AD). Approved symptomatic treatments for mild-to-moderate AD include acetylcholinesterase inhibitors and memantine, but more efficacious
Externí odkaz:
https://doaj.org/article/360e24efd56d43f9b8a6907e0297c698
Autor:
Jeffrey L. Cummings, Alireza Atri, Clive Ballard, Neli Boneva, Lutz Frölich, José Luis Molinuevo, Lars Lau Raket, Pierre N. Tariot
Publikováno v:
Alzheimer’s Research & Therapy, Vol 10, Iss 1, Pp 1-13 (2018)
Abstract Background Globalization of clinical trials has important consequences for trial planning and interpretation. This study investigated heterogeneity in patient characteristics and outcomes among world regions in the global idalopirdine Phase
Externí odkaz:
https://doaj.org/article/6ce97a19860047018f092a523dd33f2a
Autor:
Anja Ophey, Steffen Wolfsgruber, Sandra Roeske, Alexandra Polcher, Annika Spottke, Lutz Frölich, Michael Hüll, Frank Jessen, Johannes Kornhuber, Wolfgang Maier, Oliver Peters, Alfredo Ramirez, Jens Wiltfang, Inga Liepelt‐Scarfone, Sara Becker, Daniela Berg, Jörg B. Schulz, Kathrin Reetz, Jennifer Wojtala, Jan Kassubek, Alexander Storch, Monika Balzer‐Geldsetzer, Rüdiger Hilker‐Roggendorf, Karsten Witt, Brit Mollenhauer, Claudia Trenkwalder, Hans‐Ullrich Wittchen, Oliver Riedel, Richard Dodel, Michael Wagner, Elke Kalbe
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 13, Iss 1, Pp n/a-n/a (2021)
Abstract Introduction Large studies on cognitive profiles of patients with mild cognitive impairment (MCI) due to Alzheimer's disease (AD‐MCI) compared to Parkinson's disease (PD‐MCI) are rare. Methods Data from two multicenter cohort studies in
Externí odkaz:
https://doaj.org/article/8a8bd3698e2345dfb8321c686678669c
Autor:
Luca Kleineidam, Michael Wagner, Jannis Guski, Steffen Wolfsgruber, Lisa Miebach, Horst Bickel, Hans‐Helmut König, Siegfried Weyerer, Dagmar Lühmann, Hanna Kaduszkiewicz, Melanie Luppa, Susanne Röhr, Michael Pentzek, Birgitt Wiese, Wolfgang Maier, Martin Scherer, Johannes Kornhuber, Oliver Peters, Lutz Frölich, Jens Wiltfang, Piotr Lewczuk, Michael Hüll, Alfredo Ramirez, Frank Jessen, Steffi G. Riedel‐Heller, Kathrin Heser
Publikováno v:
Alzheimer's and dementia 19(5), 2056-2068 (2023). doi:10.1002/alz.12785
Subjective cognitive decline (SCD) and depressive symptoms (DS) frequently co-occur prior to dementia. However, the temporal sequence of their emergence and their combined prognostic value for cognitive decline and dementia is unclear.Temporal relati
Autor:
Jin Xu, Rebecca Green, Min Kim, Jodie Lord, Amera Ebshiana, Sarah Westwood, Alison L. Baird, Alejo J. Nevado-Holgado, Liu Shi, Abdul Hye, Stuart G. Snowden, Isabelle Bos, Stephanie J. B. Vos, Rik Vandenberghe, Charlotte E. Teunissen, Mara Ten Kate, Philip Scheltens, Silvy Gabel, Karen Meersmans, Olivier Blin, Jill Richardson, Ellen Elisa De Roeck, Sebastiaan Engelborghs, Kristel Sleegers, Régis Bordet, Lorena Rami, Petronella Kettunen, Magda Tsolaki, Frans R. J. Verhey, Daniel Alcolea, Alberto Lleó, Gwendoline Peyratout, Mikel Tainta, Peter Johannsen, Yvonne Freund-Levi, Lutz Frölich, Valerija Dobricic, Giovanni B. Frisoni, José Luis Molinuevo, Anders Wallin, Julius Popp, Pablo Martinez-Lage, Lars Bertram, Kaj Blennow, Henrik Zetterberg, Johannes Streffer, Pieter Jelle Visser, Simon Lovestone, Petroula Proitsi, Cristina Legido-Quigley, on behalf of the European Medical Information Framework Consortium
Publikováno v:
Biomedicines, Vol 9, Iss 11, p 1610 (2021)
Background: physiological differences between males and females could contribute to the development of Alzheimer’s Disease (AD). Here, we examined metabolic pathways that may lead to precision medicine initiatives. Methods: We explored whether sex
Externí odkaz:
https://doaj.org/article/6a6c1bacf1644613b95016a016cd9ea8
Autor:
Paul S. Aisen, Jeffrey Cummings, Clifford R. Jack, John C. Morris, Reisa Sperling, Lutz Frölich, Roy W. Jones, Sherie A. Dowsett, Brandy R. Matthews, Joel Raskin, Philip Scheltens, Bruno Dubois
Publikováno v:
Alzheimer’s Research & Therapy, Vol 9, Iss 1, Pp 1-10 (2017)
Abstract Basic research advances in recent years have furthered our understanding of the natural history of Alzheimer’s disease (AD). It is now recognized that pathophysiological changes begin many years prior to clinical manifestations of disease
Externí odkaz:
https://doaj.org/article/cc9d4a43fe0c412baa97aca4e96639b8