Zobrazeno 1 - 10
of 31
pro vyhledávání: '"James Travis"'
Publikováno v:
Journal of Biological Chemistry. 272:8250-8255
Destruction of components of the extracellular matrix of the lung by neutrophil elastase is believed to be a critical event in the development of obstructive lung disease. The local synthesis of alpha1-proteinase inhibitor, the controlling inhibitor
Publikováno v:
Scopus-Elsevier
The plasma alpha-1-proteinase inhibitor (API) of three mouse species Mus domesticus, M. caroli and M. pahori was isolated. Each of the species isoforms were then separated by chromatofocusing; however, no significant differences in association rate c
Autor:
Neelesh Bangalore, James Travis
Publikováno v:
Biological Chemistry Hoppe-Seyler. 375:659-666
Stimulation of human neutrophils with micromolar concentrations of N-formyl-methionyl-leucyl-phenyl-alanine (fMLP) or 4 beta-phorbol-12 beta-myristate-13 alpha-acetate (PMA), results in their degranulation and/or lysis with a concomitant release of H
Publikováno v:
Preparative Biochemistry. 20:63-74
Purification of nine plasma proteinase inhibitors and one zymogen from a single batch of human plasma, using affinity chromatography has been accomplished. Those isolated were plasminogen (lysine-Sepharose), alpha-2-antiplasmin (plasminogen-Sepharose
Publikováno v:
Biological Chemistry. 380
Human alpha1-proteinase inhibitor (alpha1-PI) is responsible for the tight control of neutrophil elastase activity which, if down regulated, may cause local excessive tissue degradation. Many bacterial proteinases can inactivate alpha1-PI by hydrolyt
Publikováno v:
Analytical biochemistry. 260(2)
The need for a quick, simple screening method for the detection of general proteolytic activity prompted us to determine whether cleavage within the reactive site loop region (RSL) of alpha1-proteinase inhibitor (alpha1-PI), a well-characterized memb
Publikováno v:
The Biochemical journal. 329
Interleukin 6 (IL-6), oncostatin M (OSM) and leukaemia-inhibitory factor (LIF) share a common signal-transducing subunit in each of their receptors and thus mediate an overlapping spectrum of biological activities. Although all of these cytokines sti
Effect of dexamethasone on alpha 1-proteinase inhibitor synthesis in human cells of monocytic origin
Publikováno v:
Biochemical and biophysical research communications. 208(1)
In this study we provide evidence for downregulation of alpha 1-Proteinase Inhibitor (alpha 1-PI) synthesis in cells of monocytic origin by the glucocorticoid analog, dexamethasone. This factor significantly reduced the basal level of alpha 1-PI expr
Publikováno v:
The International journal of biochemistry. 26(6)
1. 1. Native and cleaved α1-proteinase inhibitor was purified from ostrich serum using Sepharose-blue dextran chromatography, ammonium sulfate precipitation and ion exchange chromatography on DEAE-Toyopearl 650 M at pH 8.8 and 6.5. 2. 2. Ostrich α1
Publikováno v:
Biological chemistry Hoppe-Seyler. 375(5)
The Semi-alkaline proteinase (Seaprose) from Aspergillus melleus has been tested for its ability to either inactivate or form complexes with three human plasma proteinase inhibitors, alpha-2-macroglobulin, alpha-1-antichymotrypsin and alpha-1-protein