Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Marsha Wills-Karp"'
Autor:
Jordan Phelan, Ernst Malle, Naina Gour, Peter A. Tauber, Ursula Smole, Leonardo Puerta, Gerhard Hofer, Xiao Xiao, Luis Caraballo, Marsha Wills-Karp, Nu Yao, Bernhard Kratzer, Jan Dvorak, Cordula Köhler, Andrew P. Lane, Stephane Lajoie, Jamila Chakir, Sandra Rosskopf, Winfried F. Pickl
Publikováno v:
Nature immunology. 21(7)
The molecular basis for the propensity of a small number of environmental proteins to provoke allergic responses is largely unknown. Herein, we report that mite group 13 allergens of the fatty acid-binding protein (FABP) family are sensed by an evolu
Autor:
Anju Singh, Hwan Mee Yong, Ian P. Lewkowich, Naina Gour, Stephane Lajoie, Edward Gabrielson, Ursula Smole, Nu Yao, Marsha Wills-Karp
Publikováno v:
Mucosal immunology
Aberrant type 2 responses underlie the pathologies in allergic diseases like asthma, yet, our understanding of the mechanisms that drive them remains limited. Recent evidence suggests that dysregulated innate immune factors can perpetuate asthma path
Autor:
Charles Perkins, Lucy A. Gildea, Crystal Potter, Frank Brombacher, Marsha Wills-Karp, George Smulian, Bruce J. Aronow, Tatyana Orekov, Fred D. Finkelman, Noriko Yanase
Publikováno v:
The Journal of Experimental Medicine
IL-4Rα expression on airway smooth muscle cells is sufficient for the development of airway hyperresponsiveness.
Production of the cytokines IL-4 and IL-13 is increased in both human asthma and mouse asthma models, and Stat6 activation by the c
Production of the cytokines IL-4 and IL-13 is increased in both human asthma and mouse asthma models, and Stat6 activation by the c
Autor:
Marsha Wills-Karp
Publikováno v:
Current Opinion in Immunology. 22:777-782
Allergic diseases continue to plague modernized societies, underscoring the need to identify the molecular basis for the propensity of a small number of environmental proteins to provoke maladaptive, allergic responses. Recent data suggest that the a
Autor:
Jennifer R. Clark, Krista Dienger, Ian P. Lewkowich, Yusuke Suzuki, Marsha Wills-Karp, Stephane Lajoie, Alyssa Sproles, Alison L. Budelsky
Publikováno v:
Nature Immunology. 11:928-935
Severe asthma is associated with the production of interleukin 17A (IL-17A). The exact role of IL-17A in severe asthma and the factors that drive its production are unknown. Here we demonstrate that IL-17A mediated severe airway hyperresponsiveness (
Publikováno v:
Mucosal immunology
Allergic diseases, which have reached epidemic proportions, are caused by inappropriate immune responses to a relatively small number of environmental proteins. The molecular basis for the propensity of specific proteins to promote maladaptive, aller
Publikováno v:
Journal of Allergy and Clinical Immunology. 123:612-618
Background House dust mite (HDM) induces allergic asthma in sensitized individuals, although the mechanisms by which HDM is sensed and recognized by the airway mucosa, leading to dendritic cell (DC) recruitment, activation, and subsequent T H 2-media
Autor:
Alberto Visintin, Aurelien Trompette, Peter S. Thorne, Marsha Wills-Karp, Christopher L. Karp, Jerry P. Weiss, Senad Divanovic, Rashmi S. Hegde, Rajat Madan, Theresa L. Gioannini, Carine Blanchard
Publikováno v:
Nature
Aeroallergy results frommaladaptiveimmuneresponses toubiquitous, otherwise innocuous environmental proteins 1 . Although the proteinstargetedbyaeroallergicresponses representa tinyfraction of the airborne proteins humans are exposed to, allergenicity
Autor:
Marsha Wills-Karp, Jörg Köhl
Publikováno v:
Current Opinion in Pharmacology. 7:283-289
Complement is an ancient danger-sensor system of innate immunity, providing first-line defence against pathogens. Concordant with its pro-inflammatory properties, complement contributes to airway inflammation, hyperresponsiveness and mucus production
Autor:
John D. Lambris, Nancy S. Herman, Manoj K. Pandey, Jörg Köhl, Ian P. Lewkowich, Jeffrey A. Whitsett, Jörg Zwirner, Lihua Wang, Georgia Sfyroera, Ralf Baelder, Alyssa Sproles, Marsha Wills-Karp, Craig Gerard, Jennifer Best, Heiko Hawlisch
Publikováno v:
Journal of Clinical Investigation. 116:783-796
Complement component 5 (C5) has been described as either promoting or protecting against airway hyperresponsiveness (AHR) in experimental allergic asthma, suggesting pleomorphic effects of C5. Here we report that local pharmacological targeting of th