Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Peter K, Gregersen"'
Autor:
Maria Gutierrez-Arcelus, A. Helena Jonsson, Jatin Arora, Cristina Navarrete, Stephen S. Rich, Michael B. Brenner, Susan K. Hannes, Deepak A. Rao, Tõnu Esko, Jerome I. Rotter, Tiffany Amariuta, Yuriy Baglaenko, Peter K. Gregersen, Nikola Teslovich, Joerg Ermann, Soumya Raychaudhuri, Yang Luo, Kent D. Taylor
Publikováno v:
Nature genetics, vol 52, iss 3
Nature genetics
Nature Genetics
Nature genetics
Nature Genetics
Genetic studies have revealed that autoimmune susceptibility variants are over-represented in memory CD4+ T cell regulatory elements1–3. Understanding how genetic variation affects gene expression in different T cell physiological states is essenti
Autor:
Patrick Concannon, Amy S. Shah, Linda S. Wicker, Suna Onengut-Gumuscu, Dana Dabelea, Chen W-M., Robert P. Kimberly, Jasmin Divers, David B. Dunger, Peter K. Gregersen, Jeffrey C. Edberg, Stephen S. Rich, Huan Yang, Santica M. Marcovina, Antony J. Cutler, S L Bridges, Marian Rewers, Carla J. Greenbaum, Flemming Pociot, Jorge R. Oksenberg, Jean M. Lawrence, Inshaw Jrj., D F Santa Cruz, Andrea K. Steck, Panagiotis Deloukas, Mark A. Atkinson, John A. Todd, Emily Farber, Crouch Djm., Jane H. Buckner, Catherine C. Robertson
Publikováno v:
Robertson, C C & Type 1 Diabetes Genetics Consortium 2021, ' Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes ', Nature Genetics, vol. 53, no. 7, pp. 962-971 . https://doi.org/10.1101/2020.06.19.158071, https://doi.org/10.1038/s41588-021-00880-5
Nature genetics
Nature genetics
We report the largest and most ancestrally diverse genetic study of type 1 diabetes (T1D) to date (61,427 participants), yielding 152 regions associated to false discovery rate < 0.01, including 36 regions associated to genome-wide significance for t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5a3f66533a4cf7a2a983554fd2421f8
https://curis.ku.dk/ws/files/284012839/2020.06.19.158071v1.full.pdf
https://curis.ku.dk/ws/files/284012839/2020.06.19.158071v1.full.pdf
Autor:
Yajing Gao, Chaoying Liang, Bernard Lauwerys, Benjamin E. Wakeland, Linley Riediger, Nancy J. Olsen, Igor Dozmorov, Quan Zhen Li, Carlos Arana, Xiaoxia Zuo, Patrick M. Gaffney, Prithvi Raj, Gary S. Gilkeson, Jinchun Zhou, Joel M. Guthridge, Peter K. Gregersen, Dong-Jae Jun, Ran Song, Betty P. Tsao, Honglin Zhu, Jennifer A. Kelly, David R. Karp, Judith A. James, Swapan K. Nath, Bo Zhang, Chandrashekhar Pasare, Nicolai S. C. van Oers, Edward K. Wakeland
Publikováno v:
Genome biology, Vol. 21, no.1, p. 281 [1-26] (2020)
Genome Biology
Genome Biology, Vol 21, Iss 1, Pp 1-26 (2020)
Genome Biology
Genome Biology, Vol 21, Iss 1, Pp 1-26 (2020)
BackgroundSystemic lupus erythematosus (SLE) is a clinically heterogeneous autoimmune disease characterized by the development of anti-nuclear antibodies. Susceptibility to SLE is multifactorial, with a combination of genetic and environmental risk f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be9598291a8eeadeed2379897c0b2f7c
https://hdl.handle.net/2078.1/260417
https://hdl.handle.net/2078.1/260417
Autor:
C. Michael Stein, Annette Oeser, Peter K. Gregersen, Iván Ferraz-Amaro, Richard J. Reynolds, Robert Winchester, Joan M. Bathon, Jon T. Giles, Cecilia P. Chung, Mary Chester M. Wasko
Publikováno v:
Arthritis & Rheumatology. 69:529-541
Objective. Coronary artery disease (CAD) in the general population is characterized by an increased frequency of particular susceptibility single nucleotide polymorphisms (SNPs). Since CAD is increased in rheumatoid arthritis (RA), we sought to deter
Autor:
Soumya Raychaudhuri, Yang Luo, Cristina Navarrete, Joerg Ermann, M. M. Brenner, Maria Gutierrez-Arcelus, Jatin Arora, Susan K. Hannes, Yuriy Baglaenko, Nikola Teslovich, Peter K. Gregersen, Deepak A. Rao, Tõnu Esko, Tiffany Amariuta, A. Helena Jonsson
Understanding how genetic regulatory variation affects gene expression in different T cell states is essential to deciphering autoimmunity. We conducted a high-resolution RNA-seq time course analysis of stimulated memory CD4+T cells from 24 healthy i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50c0d98632f264a5bf77f07993c2057f
Autor:
Wei-Min Chen, Henry A. Erlich, Patrick Concannon, Emily Farber, Search for Diabetes in Youth, Ronny A. Bell, Zhennan Zhu, Lynne E. Wagenknecht, Mark A. Atkinson, Jeffrey C. Edberg, Stephen S. Rich, Steven R. Brant, Mary Helen Black, Andrea K. Steck, Jorge R. Oksenberg, Jasmin Divers, S. Louis Bridges, Catherine Pihoker, Peter K. Gregersen, Robert P. Kimberly, Marian Rewers, Suna Onengut-Gumuscu, Dana Dabelea, Jessica K. Bonnie, Catherine C. Robertson
OBJECTIVE Genetic risk scores (GRS) have been developed that differentiate individuals with type 1 diabetes from those with other forms of diabetes and are starting to be used for population screening; however, most studies were conducted in European
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9576b43c92f122bde993559f4bc0e528
https://europepmc.org/articles/PMC6385701/
https://europepmc.org/articles/PMC6385701/
Autor:
René E. M. Toes, Benjamín Fernández-Gutiérrez, H.W. van Steenbergen, Twj Huizinga, Soumya Raychaudhuri, Luis Rodriguez-Rodriguez, Ewa Berglin, A.H.M. van der Helm-van Mil, Solbritt Rantapää-Dahlqvist, Peter K. Gregersen
Publikováno v:
Arthritis & Rheumatology. 67:877-886
OBJECTIVE: For decades it has been known that the HLA-DRB1 shared epitope (SE) alleles are associated with an increased risk of development and progression of rheumatoid arthritis (RA). Recently, t ...
Autor:
S. Louis Bridges, Laura B. Hughes, Maria I. Danila, Robert M. Plenge, Altan F. Ahmed, Peter K. Gregersen, Soumya Raychaudhuri, Richard J. Reynolds
Publikováno v:
Arthritis & Rheumatology. 66:3274-3282
Objective To evaluate HLA-DRB1 genetic risk of rheumatoid arthritis (RA) in African Americans by 3 validated allele classification systems and by amino acid position and residue, and to compare genetic risk between African American and European ances
Autor:
Soumya Raychaudhuri, Tom W J Huizinga, Lars Klareskog, Harm-Jan Westra, Annette Lee, Peter K. Gregersen, Peter A. Nigrovic, Marta Martinez Bonet, Nick Teslovich, Aaron R. Quinlan, Suna Onengut-Gumuscu, Wei-Min Chen, John A. Todd, Steve Eyre, Jane Worthington, Javier Martin, Stephen S. Rich, Solbritt Rantapää-Dahlqvist, Yang Luo
We fine-mapped 76 rheumatoid arthritis (RA) and type 1 diabetes (T1D) loci outside of the MHC. After sequencing 799 1kb regulatory (H3K4me3) regions within these loci in 568 individuals, we observed accurate imputation for 89% of common variants. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce999b9db9e44a49178d767d6b2e7266
Autor:
Naoyuki Tsuchiya, Murray Baron, Takeshi Torii, Aya Kawasaki, Masatoshi Jinnin, Gabriela Riemekasten, Akira Oka, Paolo Airò, Valeria Riccieri, Yasushi Kawaguchi, Akiko Tochimoto, Minoru Hasegawa, Toshiyuki Yamamoto, Paul M. Hassoun, Tatsuya Atsumi, Marco Matucci-Cerinic, Koichiro Ohmura, Yoshihide Asano, Katherine P. Liao, Peter K. Gregersen, Philippe Dieudé, Meiko Takahashi, Inga Melchers, Shigeto Tohma, Osamu Ishikawa, Paola Caramaschi, Shinichi Sato, Chikashi Terao, Hiroshi Furukawa, Eric Hachulla, Naho Ayuzawa, Hiroki Takahashi, John Varga, Takahisa Kawaguchi, Hajime Yoshifuji, Daisuke Goto, Nicolas Hunzelmann, Manabu Fujimoto, Gabriele Valentini, Anne Cauvet, Masakazu Shimizu, Marie Hudson, Fumihiko Matsuda, Tetsuya Horita, Yannick Allanore, Hironobu Ihn, Hirahito Endo, Maria Martinez, Hidetoshi Yanagida, Kazuhiko Takehara, Masataka Kuwana, Yasuharu Tabara, Tsuneyo Mimori, Soumya Raychaudhuri
ObjectivesSystemic sclerosis (SSc) is an autoimmune disease characterised by skin and systemic fibrosis culminating in organ damage. Previous genetic studies including genome-wide association studies (GWAS) have identified 12 susceptibility loci sati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50b35c7d18d29c58a5afcace4cf38d97
https://europepmc.org/articles/PMC6733404/
https://europepmc.org/articles/PMC6733404/