Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Nasto, Luigi Aurelio"'
Autor:
Vo N; Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, 200 Lothrop Street, E1641 Biomedical Science Tower, Pittsburgh, Pennsylvania 15261, USA. von@upmc.edu, Niedernhofer LJ, Nasto LA, Jacobs L, Robbins PD, Kang J, Evans CH
Publikováno v:
Journal of orthopaedic research : official publication of the Orthopaedic Research Society [J Orthop Res] 2013 Jun; Vol. 31 (6), pp. 831-7. Date of Electronic Publication: 2013 Mar 11.
Autor:
Nasto, Luigi Aurelio, Robinson, Ar, Ngo, K, Clauson, Cl, Dong, Q, St Croix, C, Sowa, G, Pola, Enrico, Robbins, Pd, Kang, J, Niedernhofer, Lj, Wipf, P, Nv, Vo
Publikováno v:
Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 31(7)
Oxidative damage is a well-established driver of aging. Evidence of oxidative stress exists in aged and degenerated discs, but it is unclear how it affects disc metabolism. In this study, we first determined whether oxidative stress negatively impact
Study Design. NF-κB activity was pharmacologically and genetically blocked in an accelerated aging mouse model to mitigate age-related disc degenerative changes.Objective. To study the mediatory role of NF-κB signaling pathway in age-dependent inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::e3a0da3d65592fcf718c7093158c06c2
http://hdl.handle.net/11591/449095
http://hdl.handle.net/11591/449095
Autor:
Peter J. Roughley, Paul D. Robbins, Luigi Aurelio Nasto, Qing Dong, Kevin Ngo, Michael W. Epperly, Andria Rasile Robinson, James Kang, Gwendolyn Sowa, Nam Vo, Enrico Pola, Cheryl L. Clauson, S. Huq, Dong Wang, Laura J. Niedernhofer
Publikováno v:
Mechanisms of ageing and development. 134(1-2)
Intervertebral disc degeneration (IDD) is the leading cause of debilitating spinal disorders such as chronic lower back pain. Aging is the greatest risk factor for IDD. Previously, we demonstrated IDD in a murine model of a progeroid syndrome caused