Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Kalai Selvi Shanmugam"'
Autor:
Barbara Burwinkel, Bernd Frank, Hermann Brenner, Lars Beckmann, Kari Hemminki, Michael Hoffmeister, Jenny Chang-Claude, Kalai Selvi Shanmugam
Publikováno v:
Cancer Epidemiology, Biomarkers & Prevention. 15:2002-2005
The tumor necrosis factor–related apoptosis-inducing ligand receptor modulates apoptotic response by binding to the proapoptotic death receptor 4 (DR4). Perturbed apoptosis due to missense alterations in the candidate tumor suppressor gene DR4 lead
Autor:
Bernd Frank, Rita K. Schmutzler, Barbara Burwinkel, Claus R. Bartram, Kalai Selvi Shanmugam, Kari Hemminki, Barbara Wappenschmidt, Marion Kiechle, Alfons Meindl, Christian Sutter
Publikováno v:
BMC Cancer, Vol 6, Iss 1, p 268 (2006)
BMC Cancer
BMC Cancer
Background The transcription factor 7-like 2 (TCF7L2) is a critical component of the Wnt/β-catenin pathway. Aberrant TCF7L2 expression modifies Wnt signaling and mediates oncogenic effects through the upregulation of c-MYC and cyclin D. Genetic alte
Autor:
Barbara Wappenschmidt, Bernd Frank, Peter Bugert, Michael Untch, Rita K. Schmutzler, Barbara Burwinkel, Rüdiger Klaes, Alfons Meindl, Claus R. Bartram, Kalai Selvi Shanmugam, Kari Hemminki
Publikováno v:
Carcinogenesis. 26(11)
Dysregulation of apoptosis plays a crucial role in carcinogenesis. Tumour necrosis factor-related apoptosis-inducing ligand stimulates the extrinsic apoptotic pathway by binding to death receptor 4 (DR4). Thus, genetic alterations within the candidat