Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Chee-Wai Chua"'
Single-cell analysis supports a luminal-neuroendocrine transdifferentiation in human prostate cancer
Autor:
Jiahua Pan, Yu-Xiang Fang, Wenqin Luo, Helen He Zhu, Zhongzhong Ji, Wei-Qiang Gao, Chee Wai Chua, Jinming Wang, Wei Xue, Xiaomu Cheng, Liancheng Fan, Baijun Dong, Yinjie Zhu, Man Zhang, Yanqing Wang, Juju Miao, Huadong Lai, Jia Wang
Publikováno v:
Communications Biology
Communications Biology, Vol 3, Iss 1, Pp 1-15 (2020)
Communications Biology, Vol 3, Iss 1, Pp 1-15 (2020)
Neuroendocrine prostate cancer is one of the most aggressive subtypes of prostate tumor. Although much progress has been made in understanding the development of neuroendocrine prostate cancer, the cellular architecture associated with neuroendocrine
Autor:
Suk Hyung Lee, Hikmat Al-Ahmadie, Alanna B. Williams, James M. McKiernan, Cory Abate-Shen, Wenhuo Hu, Mitchell C. Benson, Mark V. Silva, Barry S. Taylor, Kwanghee Kim, Eugene J. Pietzak, Sarah K. Bergren, La Mont J. Barlow, Christopher B. Anderson, Jonathan A. Coleman, Cyriac Kandoth, David B. Solit, Michael M. Shen, Justin T. Matulay, Chee Wai Chua, Tomasz Owczarek
Publikováno v:
Cell. 173(2)
Summary Bladder cancer is the fifth most prevalent cancer in the U.S., yet is understudied, and few laboratory models exist that reflect the biology of the human disease. Here, we describe a biobank of patient-derived organoid lines that recapitulate
Publikováno v:
Histopathology. 50:648-658
Aim: Development of metastasis is one of the main causes of prostatic cancer-related death. We have previously found that up-regulation of TWIST, a highly conserved basic helix–loop–helix transcription factor, in prostatic cancer cells can promot
Autor:
Xuesong Li, Dianqi Xin, Yanqun Na, Zheng Zhang, Steve C.L. Leung, Chee Wai Chua, Xianghong Wang, Yong-Chuan Wong
Publikováno v:
Histopathology. 50:484-490
Aims: Epidermal growth factor receptor (EGFR) is suggested as one of the positive regulators in the invasive progression of renal cell cancer (RCC). Recently, Id-1 (inhibitor of differentiation or DNA binding), a helix-loop-helix transcription factor
Publikováno v:
Modern Pathology. 19:931-941
A major cause of treatment failure for prostate cancer is the development of androgen-independent metastatic disease. Id protein family, a group of basic helix-loop-helix transcription factors, has been shown to be involved in carcinogenesis and a pr
Autor:
Chee-Wai, Chua, Yung-Tuen, Chiu, Hiu-Fung, Yuen, Kwok-Wah, Chan, Xianghong, Wang, Ming-Tat, Ling, Yong-Chuan, Wong
Publikováno v:
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. 118(12)
One of the common features in advanced prostate cancer is bone metastasis. In this study, we investigated the clinical relevance of a bone factor, MSX2, in predicting the metastatic ability of prostate adenocarcinoma. Evaluation of MSX2 expression wa
Autor:
Hiu-Fung Yuen, Kwok Wah Chan, Chee-Wai Chua, Yong-Chuan Wong, Yung-Tuen Chiu, Xianghong Wang, Kwan Man, Ming-Tat Ling
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 15(13)
Purpose: Previously, FTY720 was found to possess potent anticancer effects on various types of cancer. In the present study, we aimed to first verify the role of Runx2 in prostate cancer progression and metastasis, and, subsequently, assessed if FTY7
Autor:
Xin Li, Dianqi Xin, Dan Xie, Chee Wai Chua, Xianghong Wang, Xin Yuan Guan, Steve C.L. Leung, Yanqun Na, Zheng Zhang, Yogn Chuan Wong
Publikováno v:
Human pathology. 38(4)
Recently, TWIST, a basic helix-loop-helix transcription factor, has been reported to play a key role in the metastatic progression of several types of human cancer. The aim of this study was to investigate the significance of TWIST expression in blad