Zobrazeno 1 - 10
of 166
pro vyhledávání: '"M. O'Reilly"'
Autor:
Sorbarikor Piawah, Kimmie Ng, Alan P. Venook, Federico Innocenti, Charles D. Blanke, Eileen M. O'Reilly, Marla Lipsyc-Sharf, Jeffrey A. Meyerhardt, Andrew B. Nixon, Katherine Van Loon, Tiffany M Bainter, Richard M. Goldberg, Chao Ma, Heinz-Josef Lenz, Robert J. Mayer, Sui Zhang, Fang-Shu Ou, Nadine Jackson McCleary, C. Fuchs, Donna Niedzwiecki, I-Wen Chang
Publikováno v:
J Natl Cancer Inst
BackgroundThe incidence of young-onset colorectal cancer (yoCRC) is increasing. It is unknown if there are survival differences between young and older patients with metastatic colorectal cancer (mCRC).MethodsWe studied the association of age with su
Autor:
Chia Jui Yen, James J. Harding, Stacey A. Cohen, Mehmet Akce, Yin Hsun Feng, Shukui Qin, Wen Tsung Huang, Imane El Dika, Ghassan K. Abou-Alfa, Tim Meyer, Dae Won Lee, Amanda Johnston, John S. Bomalaski, Debashis Sarker, Benjamin R. Tan, Baek Yeol Ryoo, Eileen M. O'Reilly, Yen Yang Chen, Ho Yeong Lim, Ching Liang Ho, Tsai Sheng Yang
Publikováno v:
Cancer. 127:4585-4593
Background Arginine starvation depletes the micronutrients required for DNA synthesis and interferes with both thymidylate synthetase activity and DNA repair pathways in preclinical models of hepatocellular carcinoma (HCC). Pegylated arginine deimina
Autor:
Vinod P. Balachandran, Wungki Park, Jeffrey A. Drebin, Kenneth Seier, Alice C. Wei, Kenneth H. Yu, Jared Bassmann, Kevin C. Soares, William R. Jarnagin, Christopher H. Crane, Mithat Gonen, Marsha Reyngold, T. Peter Kingham, Joshua S. Jolissaint, Michael I. D’Angelica, Eileen M. O'Reilly, Anna M. Varghese
Publikováno v:
Hepatobiliary Surg Nutr
OBJECTIVE We sought to compare overall survival (OS) and disease control for patients with localized pancreatic ductal adenocarcinoma (PDAC) treated with ablative dose radiotherapy (A-RT) versus resection. SUMMARY BACKGROUND DATA Locoregional treatme
Autor:
Charles Dolladille, Laurent Poulain, Eileen M. O'Reilly, Basile Chrétien, Alexandra Leary, Antonio González-Martín, Isabelle Ray-Coquard, Joachim Alexandre, Pierre-Marie Morice, Kathleen N. Moore
Publikováno v:
The Lancet Haematology. 8:e122-e134
Summary Background Poly(ADP-ribose) polymerase (PARP) inhibitors have shown efficacy and acceptable safety in a range of neoplasms, particularly in ovarian cancers. However, some concerns have emerged regarding rare and delayed adverse events includi
Autor:
Aslihan Yavas, Akimasa Hayashi, Anna M. Varghese, Amanda Erakky, Yu-Jui Ho, Christine A. Iacobuzio-Donahue, Eileen M. O'Reilly, David S. Klimstra, Caitlin A. McIntyre, Michael Overholtzer, Jerry P. Melchor, Olca Basturk, Winston Wong
Publikováno v:
Modern Pathology
Entosis is a type of regulated cell death that promotes cancer cell competition. Though several studies have revealed the molecular mechanisms that govern entosis, the clinical and genetic correlates of entosis in human tumors is less well understood
Autor:
P. Osterlund, S. Kinos, P. Pfeiffer, T. Salminen, J.J.M. Kwakman, J.-E. Frödin, C.H. Shah, H. Sorbye, R. Ristamäki, P. Halonen, L.M. Soveri, E. Heervä, A. Ålgars, M. Bärlund, H. Hagman, R. McDermott, M. O’Reilly, R. Röckert, G. Liposits, R. Kallio, P. Flygare, A.J. Teske, E. van Werkhoven, C.J.A. Punt, B. Glimelius
Publikováno v:
ESMO open, 7(3):100427. Elsevier BV
ESMO Open
ESMO Open
Publisher Copyright: © 2022 The Author(s) Background: Capecitabine- or 5-fluorouracil (5-FU)-based chemotherapy is widely used in many solid tumours, but is associated with cardiotoxicity. S-1 is a fluoropyrimidine with low rates of cardiotoxicity,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a13f97b5f1a9aa6049448c1fbbc3f020
http://urn.fi/urn:nbn:fi-fe2023071190533
http://urn.fi/urn:nbn:fi-fe2023071190533
Autor:
Ghassan K. Abou-Alfa, Eileen M. O'Reilly, Jinru Shia, Richard K. G. Do, Jennifer Ma, Joanne F. Chou, Marinela Capanu, Imane El Dika, Anna D. Hrabovsky, James J. Harding, Michele Ly, Brittanie M Millang
Publikováno v:
Cancer Medicine
Cancer Medicine, Vol 9, Iss 20, Pp 7453-7459 (2020)
Cancer Medicine, Vol 9, Iss 20, Pp 7453-7459 (2020)
Background Patients with advanced hepatocellular carcinoma (HCC) who received second line sorafenib plus doxorubicin following disease progression on sorafenib were shown retrospectively to have improved progression free survival (PFS) and overall su
Autor:
Eileen M. O'Reilly, Kenneth H. Yu, Caitlin A. McIntyre, David P. Kelsen, Wungki Park, Jorge S. Reis-Filho, Nima Ghalehsari, Ghassan K. Abou-Alfa, Liying Zhang, Danny N. Khalil, Nadeem Riaz, Xin Pei, Sree Bhavani Chalasani, Joanne F. Chou, Jiapeng Chen, Nicolas Lecomte, Vinod P. Balachandran, Nikolaus Schultz, Imane El Dika, M. Capanu, Pier Selenica, James J. Harding, Anna M. Varghese, Timothy A. Chan, Winston Wong, Vladimir Makarov, Michael F. Berger, S.N. Powell, Mark E. Robson, Christine A. Iacobuzio-Donahue, Zoe McKinnell
Publikováno v:
Clin Cancer Res
Purpose: Genomic methods can identify homologous recombination deficiency (HRD). Rigorous evaluation of their outcome association to DNA damage response–targeted therapies like platinum in pancreatic ductal adenocarcinoma (PDAC) is essential in max
Autor:
David P. Ryan, Eileen M. O'Reilly, Kenneth H. Yu, James M. Roach, Donald A. Richards, Spencer H. Shao, Julie Wolf, Tanios Bekaii-Saab, Diletta Barone, Keith T. Flaherty, Devalingam Mahalingam, Molly Rosano, Silva Krause
Publikováno v:
Eur J Cancer
Background Necuparanib, a rationally engineered low-molecular-weight heparin, combined with gemcitabine/nab-paclitaxel showed an encouraging safety and oncologic signal in a phase Ib trial. This randomised multicentre phase II trial evaluates the add
Publikováno v:
Cancer Medicine, Vol 9, Iss 13, Pp 4572-4580 (2020)
Cancer Medicine
Cancer Medicine
Introduction Evidence‐based recommendations on duration of multiagent systemic therapy for LAPC are lacking. Herein, we assess the impact of duration of combination systemic therapy on survival of patients with LAPC. Methods The National Cancer Dat