Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Katie Streicher"'
Autor:
Bonnie S. Glisson, Yanan Zheng, Bhumsuk Keam, Steven Eck, Sandip Pravin Patel, Sanjay Goel, Matthew Gribbin, James Ohr, Naiyer A. Rizvi, Danielle M. Townsley, Katie Streicher, Reva Schneider, John D. Powderly, Jennifer Burton, Rom Leidner, Robert L. Ferris
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 26(20)
Purpose: Immune checkpoint blockade has demonstrated clinical benefits across multiple solid tumor types; however, resistance and relapse often occur. New immunomodulatory targets, which are highly expressed in activated immune cells, are needed. MED
Autor:
Christopher Morehouse, Sarfaraz Hasni, Jodi L. Karnell, Michael P. Cancro, Kamelia Zerrouki, Miguel Sanjuan, Brian Naiman, Richard N. Hanna, Zerai Manna, Katie Streicher, Rachel Ettinger, Shu Wang, Saifur Rahman, Phillip S. Gross, Roland Kolbeck, Richard M. Siegel, Nicholas Holoweckyj, Varsha Kumar, Raphaela Goldbach-Mansky, Jingya Wang, Hao Liu
Publikováno v:
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Although the aetiology of systemic lupus erythematosus (SLE) is unclear, dysregulated B cell responses have been implicated. Here we show that an unusual CD11chiT-bet+ B cell subset, with a unique expression profile including chemokine receptors cons
Autor:
Ashok Kumar Gupta, Koustubh Ranade, Fernanda Pilataxi, Philip Brohawn, Brandon W. Higgs, Christopher Morehouse, Katie Streicher
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 24(16)
Purpose: To identify a predictive biomarker for durvalumab, an anti–programmed death ligand 1 (PD-L1) mAb. Experimental Design: RNA sequencing of 97 advanced-stage non–small cell lung carcinoma (NSCLC) biopsies from a nonrandomized phase Ib/II cl
Autor:
Ronald Herbst, Soumya Chatterjee, Sarah Sweeny, Jing-Jing Li, Daniel Cimbora, Katie Streicher, Elena Schiopu, Armando Flor, Kaushik Patra, Vivien Hsu, Eliezer Katz, Wenliang Yao, Kathleen McKeever, Barbara White, Jorn Drappa
Publikováno v:
Arthritis Research & Therapy
Systemic sclerosis (SSc) is a clinically heterogeneous, life-threatening disease characterized by fibrosis, microvasculopathy, and autoimmunity. Extensive nonclinical and clinical data implicate B cells in the pathogenesis of SSc. MEDI-551 is an inve
Autor:
Bahija Jallal, Lorin Roskos, Yihong Yao, S. Yoo, Zheng Liu, Linda Chang, Brandon W. Higgs, Laura Richman, Meina Liang, Bing Wang, Inna Vainshtein, Katie Streicher, Wendy I. White
Publikováno v:
Clinical pharmacology and therapeutics. 93(6)
A type I interferon (IFN) gene signature shared by systemic lupus erythematous (SLE) and systemic sclerosis (SSc) was used to evaluate an anti-type I IFN-α receptor (IFN-αR) monoclonal antibody, MEDI-546, in a phase I trial in SSc. MEDI-546 suppres
Autor:
Philip Brohawn, Zheng Liu, Yihong Yao, Christopher Morehouse, Katie Streicher, Xiaobing Luo, Koustubh Ranade, Robert W. Georgantas, Bahija Jallal, Brandon W. Higgs, Lydia Greenlees, Laura Richman, Wei Zhu
Publikováno v:
Pigment cellmelanoma research. 27(2)
Expression profiling of microRNAs in melanoma lesional skin biopsies compared with normal donor skin biopsies, as well as melanoma cell lines compared with normal melanocytes, revealed that hsa-miR-206 was down-regulated in melanoma (-75.4-fold, P =
Autor:
Ronald Herbst, Heng Zhao, Lihua Huang, Haihong Zhong, Baohui Han, Philip Brohawn, Song Wu, Xin Yao, Sarah Conley, Dong Shen, Yinong Sebastian, Yihong Yao, Yanjie Niu, Brandon W. Higgs, Wei Zhang, Zhibin Hu, David A. Tice, Wei Zhu, Bahija Jallal, Meggan Czapiga, Yizhuo Zhao, Katie Streicher, Zheng Liu, Meng Zhu, Jiaqi Huang, Vaheh Oganesyan, Xinying Su, Haihua Fu, Hongbing Shen, Xiaoxiao Ge, Yi Gu, Yue Jiang, Shyoung Li, Lin Xu, Yuqing Lou, Zhan Xiao, Liyan Jiang, Jianren Gu, Chris Morehouse
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 12, Iss 4, p e1005895 (2016)
PLoS Genetics, Vol 12, Iss 4, p e1005895 (2016)
Small cell lung cancer (SCLC) is an aggressive disease with poor survival. A few sequencing studies performed on limited number of samples have revealed potential disease-driving genes in SCLC, however, much still remains unknown, particularly in the
Autor:
David Fiorentino, Katie Streicher, Chris Morehouse, Brandon W. Higgs, Anthony A. Amato, Steven A. Greenberg, Yihong Yao, Wei Zhu, Lydia Greenlees, Laura Richman, Nan Shen, Koustubh Ranade, Bahija Jallal
Publikováno v:
BMC Medical Genomics
BMC Medical Genomics, Vol 5, Iss 1, p 53 (2012)
BMC Medical Genomics, Vol 5, Iss 1, p 53 (2012)
Background Leukocyte infiltration plays an important role in the pathogenesis and progression of myositis, and is highly associated with disease severity. Currently, there is a lack of: efficacious therapies for myositis; understanding of the molecul