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pro vyhledávání: ''
Autor:
Julio C. Chavez, James Drew, John P. Leonard, Erin Mulvey, Sonali M. Smith, Leandro Cerchietti, Nancy L. Bartlett, John L. Reagan, Jeffrey A. Jones, Ann S. LaCasce, Peter Martin, Maria Victoria Revuelta, Chengqing Wu
Publikováno v:
Blood. 139:1147-1159
Resistance to standard immunochemotherapy remains an unmet challenge in diffuse large B-cell lymphoma (DLBCL), and aberrant DNA methylation may contribute to chemoresistance. Promising early-phase results were reported with rituximab, cyclophosphamid
Autor:
Hongseok Yun, Seung Hong Choi, Ka Young Lim, Seung-Ki Kim, Yumi Shim, Tae Min Kim, Jin-Woo Park, Hyunhee Kim, Jeongwan Kang, Sung Hye Park, Chul-Kee Park, Kwanghoon Lee, Jae Kyung Won
Publikováno v:
Laboratory Investigation; a Journal of Technical Methods and Pathology
Mismatch repair-deficient (MMRD) brain tumors are rare among primary brain tumors and can be induced by germline or sporadic mutations. Here, we report 13 MMRD-associated (9 sporadic and 4 Lynch syndrome) primary brain tumors to determine clinicopath
Autor:
Anna Wall, Herve Ghesquieres, Viola Poeschel, Jesse G. Dixon, Hervé Tilly, Marita Ziepert, Amy S. Ruppert, Qian Shi, David Cunningham, Norbert Schmitz, Christopher R. Flowers, Corinne Haioun, Jocelyne Flament, Gilles Salles
Great heterogeneity in survival exists for patients newly diagnosed with diffuse large B-cell lymphoma (DLBCL). Three scoring systems incorporating simple clinical parameters (age, lactate dehydrogenase, number/sites of involvement, stage, performanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86b84f2887e4b5caa58b54159bae05ed
Publikováno v:
Aging (Albany NY)
Circadian dysregulation involves malignant tumor initiation and progression, but the understanding of circadian rhythm's roles in bladder cancer (BCa) remains insufficient. The circadian rhythm-related genes were collected and clustered based on the
Autor:
Philipp le Coutre, Véronique Bédoucha, Delphine Rea, Dennis Dong Hwan Kim, Elza Lomaia, Michael J. Mauro, Andre Abdo, Lynette Chee, Sergey Voloshin, Dong-Wook Kim, Laura Fogliatto, Paola Aimone, Yosuke Minami, Alex Allepuz, Mario Annunziata, Jane F. Apperley, Susanne Saussele, Jorge E. Cortes, Andreas Hochhaus, Naeem Chaudhri, Carla Boquimpani, Koji Sasaki, Sara Quenet, Timothy P. Hughes, Anna G. Turkina, Valentín García-Gutiérrez
Publikováno v:
Blood
Patients with chronic myeloid leukemia in chronic phase (CML-CP) resistant/intolerant to ≥2 tyrosine kinase inhibitors (TKIs) are at high risk of experiencing poor outcomes because of disease biology and inadequate efficacy and/or safety of current
Autor:
P. Andrew Futreal, Ken Furudate, Marina Konopleva, Sanam Loghavi, Guillermo Garcia-Manero, Sa A. Wang, Yuya Sasaki, Gheath Alatrash, Musa Yilmaz, Koji Sasaki, Naveen Pemmaraju, Latasha Little, Tapan M. Kadia, Koichi Takahashi, Farhad Ravandi, Kiyomi Morita, Curtis Gumbs, Jairo Matthews, Feng Wang, Hagop M. Kantarjian, Courtney D. DiNardo, Richard E. Champlin, Naval Daver, Tomoyuki Tanaka
Publikováno v:
Blood
Introduction While clonal hematopoiesis (CH) can precede the development of AML, preleukemic CH can persist after attaining remission. In rare cases, non-leukemic CH can also emerge after remission. Long-term clonal dynamics of persistent CH or emerg
Autor:
Philomena Colucci, Jingbo Yu, Jonathan Kish, Dilan Paranagama, Shreekant Parasuraman, Kevin C Lord, Ivy Altomare
Publikováno v:
Clinical Lymphoma Myeloma and Leukemia. 21:e915-e921
Background Polycythemia vera (PV) is a myeloproliferative neoplasm affecting >100,000 people in the United States annually. Patients (pts) with PV are at risk for thromboembolic events (TEs), premature death, and high symptom burden. Hydroxyurea (HU)
Autor:
Zhigang Tian, Xiaokun Shen, Rui Sun, Chuang Guo, Binqing Fu, Haiming Wei, Jiabin Li, Dongyao Wang, Ying Ye, Junfei Zhang, Yanyan Liu
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-13 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Patients with chronic hepatitis B (CHB) undergoing interferon (IFN)-α-based therapies often exhibit a poor HBeAg serological response. Thus, there is an unmet need for new therapies aimed at CHB. This study comprised two clinical trials, including 1
Autor:
Bogdan Małkowski, Karolina Szewczyk-Golec, Jarosław Nuszkiewicz, Marta Pawłowska, Alina Woźniak, Marta Maruszak, Jolanta Czuczejko
Publikováno v:
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity, Vol 2021 (2021)
Oxidative Medicine and Cellular Longevity, Vol 2021 (2021)
Lip, oral cavity, and pharyngeal cancers (LOCP) constitute a group of rare neoplasms with unfavorable prognosis. So far, not much is known about the role of vitamin D and oxidative stress in the pathogenesis of LOCP in the European population. The ai
Autor:
Lixia Hao, Jun Yuan, Bagen Tong, Yan-Bo Jia, Zi-Hong Liang, Pengfei Cui, Xuemei He, Run-Xiu Zhu, Fan Yang, Lizhen Zhao
Publikováno v:
Aging (Albany NY)
Agomelatine was a novel and melatonergic antidepressant. The present study was conducted to find out whether age was an important factor for agomelatine in treating depressed type 2 diabetes mellitus (T2DM) patients. In total, 193 depressed T2DM pati