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Publikováno v:
Internal Medicine Journal. 52:1733-1740
Background Peripherally inserted central catheters (PICCs) are commonly used in cancer patients. PICC-associated upper limb venous thromboembolism (PaULVTE, non-deep and deep involving veins proximal to the brachial vein) and distant VTE (i.e. pulmon
Publikováno v:
Blood
As the coronavirus disease (COVID-19) pandemic led to a global health crisis, there were limited treatment options and no prophylactic therapies for those exposed to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Convalescent plasma is
Autor:
Ashish Panigrahi, Constantine S. Tam, Piers Blombery, Xiangting Chen, John F. Seymour, Dennis A. Carney, Andrew H. Wei, Thomas E Lew, Mary Ann Anderson, Andrew W. Roberts, Ella R. Thompson, David C. S. Huang, Tamia Nguyen, David Westerman, Michael A. Dengler, Victor S Lin, Sasanka M. Handunnetti, Jerry M. Adams
Publikováno v:
Blood. 139:1198-1207
The BCL2 inhibitor venetoclax has established therapeutic roles in chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML). As BCL2 is an important determinant of survival of both myeloid progenitor and B cells, we investigated whether cl
Autor:
Julio C. Chavez, James Drew, John P. Leonard, Erin Mulvey, Sonali M. Smith, Leandro Cerchietti, Nancy L. Bartlett, John L. Reagan, Jeffrey A. Jones, Ann S. LaCasce, Peter Martin, Maria Victoria Revuelta, Chengqing Wu
Publikováno v:
Blood. 139:1147-1159
Resistance to standard immunochemotherapy remains an unmet challenge in diffuse large B-cell lymphoma (DLBCL), and aberrant DNA methylation may contribute to chemoresistance. Promising early-phase results were reported with rituximab, cyclophosphamid
Pembrolizumab for B-cell lymphomas relapsing after or refractory to CD19-directed CAR T-cell therapy
Autor:
Simon F. Lacey, Stephen J. Schuster, Elise A. Chong, Sunita D. Nasta, Jakub Svoboda, Marco Ruella, Siddharth Bhattacharyya, E. John Wherry, Cécile Alanio, Daniel J. Landsburg
Publikováno v:
Blood
CD19-directed chimeric antigen receptor–modified (CAR T) T cells achieve durable remissions in about 30% to 40% of relapsed/refractory large B-cell lymphomas. T-cell exhaustion and/or an immunosuppressive tumor microenvironment may contribute to CA
The single freshly skinned muscle fibre technique was used to investigate Ca2+- and Sr2+-activation properties of skeletal muscle fibres from elderly women (66–90 years). Muscle biopsies were obtained from the vastus lateralis muscle. Three populat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::480cb17a3831fa997f28d1390de27844
Autor:
Anna Wall, Herve Ghesquieres, Viola Poeschel, Jesse G. Dixon, Hervé Tilly, Marita Ziepert, Amy S. Ruppert, Qian Shi, David Cunningham, Norbert Schmitz, Christopher R. Flowers, Corinne Haioun, Jocelyne Flament, Gilles Salles
Great heterogeneity in survival exists for patients newly diagnosed with diffuse large B-cell lymphoma (DLBCL). Three scoring systems incorporating simple clinical parameters (age, lactate dehydrogenase, number/sites of involvement, stage, performanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86b84f2887e4b5caa58b54159bae05ed
Autor:
Andrea Mayado, Iván Álvarez-Twose, María Jara-Acevedo, Ana Gabriela Henriques, Javier I. Muñoz-González, Laura Sánchez-Muñoz, Alba Pérez-Pons, Alberto Orfao, Carolina Caldas, Lidia Torres-Rivera, Andrés C. García-Montero, Almudena Matito
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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Circulating tumor mast cells (CTMCs) have been identified in the blood of a small number of patients with advanced systemic mastocytosis (SM). However, data are limited about their frequency and prognostic impact in patients with MC activation syndro
Autor:
Anna-Maria Fink, Tobias Gaska, Barbara Eichhorst, Werner Freier, Clemens-Martin Wendtner, Can Zhang, Julia von Tresckow, Kirsten Fischer, Ursula Vehling-Kaiser, Eugen Tausch, Stephan Stilgenbauer, Marcel Reiser, Martina Stauch, Michael J. Eckart, Sandra Robrecht, Petra Langerbeins, Moritz Fürstenau, Paula Cramer, Rudolf Schlag, Lothar Müller, Karl-Anton Kreuzer, Michael Hallek, Christina Balser, Othman Al-Sawaf
Publikováno v:
Blood. 139:177-187
Observation is the current standard of care for patients with early-stage asymptomatic chronic lymphocytic leukemia (CLL), as chemotherapy-based interventions have failed to prolong survival. We hypothesized that early intervention with ibrutinib wou
Autor:
Hans-Juergen Wester, Alexander Haug, Marcus Hacker, Markus Raderer, Asha Leisser, Stefan Schmitl, Ingrid Simonitsch-Klupp, Wolfgang Lamm, Johannes Rohrbeck, Marius E. Mayerhoefer, Michael Weber, Lukas Nics, Barbara Kiesewetter
Publikováno v:
Blood. 139:240-244
Posttreatment evaluation of gastric mucosa-associated lymphoid tissue (MALT) lymphoma currently relies on esophagogastroduodenoscopy with histological assessment of biopsies. Overexpression of the G protein–coupled C-X-C chemokine receptor type 4 (