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Autor:
Shusuke Akamatsu, Hideaki Takada, Ryoichi Saito, Takayuki Goto, Akihiro Hamada, Toru Sakatani, Takeshi Sano, Yuki Kita, Kei Mizuno, Keiyu Matsumoto, Osamu Ogawa, Kenji Nakamura, Takashi Kobayashi, Tatsuaki Tsuruyama, Kaoru Murakami
Publikováno v:
Cancer Science
Overcoming cisplatin (CDDP) resistance is a major issue in urothelial cancer (UC), in which CDDP‐based chemotherapy is the first‐line treatment. WEE1, a G2/M checkpoint kinase, confers chemoresistance in response to genotoxic agents. However, the
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-12 (2021)
BMC Cancer
BMC Cancer
Background Brain metastases were rare in esophageal cancer patients. Using the Surveillance, Epidemiology, and End Results (SEER) database, the present study investigated the incidence, risk and prognostic factors of brain metastases in esophageal ca
Publikováno v:
Modern Pathology. 34:1738-1749
Invasive stratified mucin-producing carcinoma (ISMC) is a recently described entity of human papillomavirus (HPV)-associated endocervical adenocarcinoma with phenotypic plasticity and aggressive clinical behavior. To identify the cell of origin of IS
Publikováno v:
Hematology/Oncology and Stem Cell Therapy, Vol 14, Iss 3, Pp 252-256 (2021)
Primary myelofibrosis (PMF) is a subtype of BCR-ABL1 negative myeloproliferative neoplasm. Its characteristic features include clonal myeloproliferation, dysregulation of kinase signaling pathway, abnormal release of cytokines leading to fibrosis in
Autor:
Ludovico Muzii, Giuseppe Caruso, Pierluigi Benedetti Panici, Violante Di Donato, Innocenza Palaia, Martina Leopizzi, Carlo Della Rocca, Giorgia Perniola, Roberta Gallo, Angelina Pernazza
Publikováno v:
Anticancer Research. 41:4431-4438
BACKGROUND/AIM Although still controversial, the current treatment for locally advanced neuroendocrine carcinoma of the cervix (NECC) relies on chemoradiation (CRT). The aim of this study is to evaluate the alternative role of combined chemotherapy a
Autor:
Paul M.L. Janssen, Nahush A. Mokadam, Esthela J. Artiga, Maciej Pietrzak, Brian J. Hansen, Bryan A. Whitson, Vadim V. Fedorov, Halina Dobrzynski, Peter J. Mohler, Amy Webb, Anuradha Kalyanasundaram, Ning Li, Brandon J. Biesiadecki, John D. Hummel
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports
Scientific Reports
Heart failure (HF) is frequently accompanied with the sinoatrial node (SAN) dysfunction, which causes tachy-brady arrhythmias and increased mortality. MicroRNA (miR) alterations are associated with HF progression. However, the transcriptome of HF hum
Autor:
Yukio Naya, Kyokusin Hou, Satoko Kojima, Manato Kanesaka, Takahito Suyama, Hiroshi Masuda, Kazuhiro Araki, Ayumi Fujimoto
Publikováno v:
Anticancer Research. 41:4443-4446
BACKGROUND Androgen deprivation therapy (ADT) is one of the most effective treatments for advanced prostate cancer (PCa). However, it has been reported that the use of ADT is significantly associated with an increased risk of acute kidney injury (AKI
Autor:
Zhigang Liu, Hesong Liu, Qiliang Yin, Zhen Guo, Zhihua Cui, Hua He, Shijie Lan, Di Wu, Yingying Yu, Lingling Liang
Publikováno v:
Melanoma Research
Retinopathy is a rare side effect of interferon α-2b treatment. The goal of this study was to prospectively investigate the clinical characteristics of Chinese patients with melanomas who developed retinopathy following high doses of interferon α-2
Autor:
Koichi Takahashi, Nitin Jain, Guillermo Garcia-Manero, Lucia Masarova, Sa Wang, Courtney D. DiNardo, Naveen Pemmaraju, Guillermo Montalban Bravo, Tapan M. Kadia, Sanam Loghavi, Musa Yilmaz, Ghayas C. Issa, Koji Sasaki, Elias Jabbour, Steven M. Kornblau, Abhishek Maiti, Marina Konopleva, Lianchun Xiao, Curtis Lachowiez, Maria Adeoti, Farhad Ravandi, Michael Andreeff, Nicholas J. Short, Gautam Borthakur, Hagop M. Kantarjian, Naval Daver, Yesid Alvarado
Publikováno v:
J Clin Oncol
PURPOSE Sixty percent of newly diagnosed patients with acute myeloid leukemia (ND-AML) receiving frontline therapy attain a complete response (CR), yet 30%-40% of patients relapse. Relapsed or refractory AML (R/R-AML) remains a particularly adverse p
Publikováno v:
Cancer Medicine, Vol 10, Iss 17, Pp 5757-5764 (2021)
Cancer Medicine
Cancer Medicine
Introduction Pulmonary nuclear protein of the testis (NUT) midline carcinoma (NMC) is a aggressive cancer with t (15, 19) translocation. Here we present the clinicopathological characteristics and molecular genetics alterations of primary pulmonary N