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Publikováno v:
Journal of Clinical Oncology. 41:1331-1338
PURPOSE Immunohistochemistry (IHC) is a newer technique for assessing the estrogen receptor (ER) status of breast cancers, with the potential to overcome many of the shortcomings associated with the traditional ligand-binding assay (LBA). The purpose
Autor:
Qinghua Han, Lindsey A. Barner, Lawrence D. True, Chenyi Mao, Andrew Janowczyk, Pingfu Fu, Robert Serafin, Nicholas P. Reder, Anant Madabhushi, Jonathan T. C. Liu, Can Fahrettin Koyuncu, Patrick Leo, Sarah Hawley, Weisi Xie, Hongyi Huang, Jonathan L. Wright, Gan Gao, Adam K. Glaser, Soyoung Kang, Kevin Bishop, Nadia Postupna, C. Dirk Keene, Joshua C. Vaughan
Publikováno v:
Cancer Res
Prostate cancer treatment planning is largely dependent upon examination of core-needle biopsies. The microscopic architecture of the prostate glands forms the basis for prognostic grading by pathologists. Interpretation of these convoluted three-dim
Autor:
Martin Bornhäuser, Michael Kramer, Jan-Niklas Eckardt, Christian Thiede, Johannes Schetelig, Karsten Wendt, Ulrich Schuler, Frank Kroschinsky, Jan Moritz Middeke, Katja Sockel, Christoph Röllig, Anas Shekh Sulaiman, Sebastian Riechert, Tim Schmittmann
Publikováno v:
Leukemia
The evaluation of bone marrow morphology by experienced hematopathologists is essential in the diagnosis of acute myeloid leukemia (AML); however, it suffers from a lack of standardization and inter-observer variability. Deep learning (DL) can proces
Publikováno v:
Modern Pathology. 34:1738-1749
Invasive stratified mucin-producing carcinoma (ISMC) is a recently described entity of human papillomavirus (HPV)-associated endocervical adenocarcinoma with phenotypic plasticity and aggressive clinical behavior. To identify the cell of origin of IS
Publikováno v:
Cancer Medicine, Vol 10, Iss 17, Pp 5757-5764 (2021)
Cancer Medicine
Cancer Medicine
Introduction Pulmonary nuclear protein of the testis (NUT) midline carcinoma (NMC) is a aggressive cancer with t (15, 19) translocation. Here we present the clinicopathological characteristics and molecular genetics alterations of primary pulmonary N
Autor:
Mai Iwaya, Tomoyuki Nakajima, Takayuki Watanabe, Yusuke Miyagawa, Yasuhiro Kinugawa, Takeshi Uehara, Takashi Muraki, Yasuhiro Kuraishi, Takeji Umemura
Publikováno v:
Diagnostic Pathology, Vol 16, Iss 1, Pp 1-8 (2021)
Diagnostic Pathology
Diagnostic Pathology
Background Pancreaticobiliary maljunction (PBM) is a condition characterized by chronic inflammation due to refluxed pancreatic juice into the biliary tract that is associated with an elevated risk of biliary tract cancer. DNA double-strand breaks (D
Autor:
Yoshihiro Komohara, Toshiyuki Shima, Masayuki Shimoda, Remi Mito, Yusuke Shinchi, Koei Ikeda, Makoto Suzuki, Takuro Sakagami, Eri Matsubara, Yae Kanai, Yukio Fujiwara
Publikováno v:
Pathology International. 71:666-673
CD163 is one of the scavenger receptors expressed on macrophages. However, several immunohistochemical studies have demonstrated that CD163 is also detected on cancer cells, and is associated with a poor prognosis. In the present study, we detected C
Autor:
Elly M. Hol, René S. Kahn, Stella Dracheva, Nina Notman, Gijsje J. L. J. Snijders, Danny M Nispeling, Marjolein A. M. Sneeboer, Lot D. de Witte, Marco P. Boks, Yujie He, Lotte C Houtepen, Amber Berdenis van Berlekom
Publikováno v:
Epigenomics, 13, 1157-1169. Future Medicine Ltd.
Epigenomics, 13, 15, pp. 1157-1169
Epigenomics, 13, 1157-1169
Epigenomics
Epigenomics, 13, 15, pp. 1157-1169
Epigenomics, 13, 1157-1169
Epigenomics
Item does not contain fulltext Aim: Identify grey- and white-matter-specific DNA-methylation differences between schizophrenia (SCZ) patients and controls in postmortem brain cortical tissue. Materials & methods: Grey and white matter were separated
Autor:
Martha A. Zeiger, Zhiyang Liu, Brittany A. McKelvey, Leslie Cope, Christopher B. Umbricht, Yongchun Wang, Lisa M. Rooper
Publikováno v:
J Cancer Res Clin Oncol
BACKGROUND: While molecular testing is a promising strategy for preoperative assessment of cytologically indeterminate thyroid nodules, thyroid fine needle aspiration biopsy (FNA) presents unique challenges for molecular assays, including contaminati
Autor:
Shinichiro Takahashi, Toshihiro Suzuki, Katsuhiko Uesaka, Motohiro Kojima, Satoshi Okubo, Yasuhiro Shimizu, Hirochika Toyama, Genichiro Ishii, Naoto Gotohda, Soichiro Morinaga, Masayoshi Hioki
Publikováno v:
Cancer Science
Several therapeutic regimens, including neoadjuvant chemoradiation therapy (NACRT), have been reported to serve as anticancer immune effectors. However, there remain insufficient data regarding the immune response after NACRT in pancreatic ductal ade