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Autor:
Takayuki Kondo, Stewart Macdonald, Cornelius Engelmann, Abeba Habtesion, Jane Macnaughtan, Gautam Mehta, Rajeshwar P. Mookerjee, Nathan Davies, Marco Pavesi, Richard Moreau, Paolo Angeli, Vicente Arroyo, Fausto Andreola, Rajiv Jalan
Publikováno v:
Cell Death and Disease, Vol 13, Iss 1, Pp 1-12 (2021)
Cell Death & Disease
Cell Death & Disease
Acute-on-chronic liver failure (ACLF) is characterized predominantly by non-apoptotic forms of hepatocyte cell death. Necroptosis is a form of programmed lytic cell death in which receptor interacting protein kinase (RIPK) 1, RIPK3 and phosphorylated
Autor:
Beiping Zhong, Bing Cheng, Xiaoming Huang, Qian Xiao, Zhitong Niu, Yu-feng Chen, Qiang Yu, Wenyu Wang, Xiao-Jian Wu
Publikováno v:
Cell Death and Disease, Vol 13, Iss 1, Pp 1-15 (2021)
Cell Death & Disease
Cell Death & Disease
Cancer-associated fibroblasts (CAFs) have been shown to play a strong role in colorectal cancer metastasis, yet the underlying mechanism remains to be fully elucidated. Using CRC clinical samples together with ex vivo CAFs-CRC co-culture models, we f
Autor:
Kimia Sobhani, Jennifer E. Van Eyk, James L. Stewart, Warren G. Tourtellotte, Justin Darrah, Joslyn Foley, Wendy Cozen, Karen L. Reckamp, Susan Cheng, Alain C. Mita, So Yung Choi, Carissa A. Huynh, Noah Merin, Sandy Joung, Tucker Lemos, Robert Vescio, Ronald Paquette, Dermot P.B. McGovern, Edwin C. Frias, John Prostko, Omid Hamid, Joseph E. Ebinger, Emebet Mengesha, Reva Basho, Greg Botwin, Jun Gong, Nathalie Nguyen, Jonathan Braun, Inderjit Mehmi, Jane C. Figueiredo, Akil Merchant, Gil Y. Melmed, Laurel J Finster
Publikováno v:
Cancer Res
Longitudinal studies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine-induced immune responses in patients with cancer are needed to optimize clinical care. In a prospective cohort study of 366 (291 vaccinated) patients, we mea
Autor:
Philomena Colucci, Jingbo Yu, Jonathan Kish, Dilan Paranagama, Shreekant Parasuraman, Kevin C Lord, Ivy Altomare
Publikováno v:
Clinical Lymphoma Myeloma and Leukemia. 21:e915-e921
Background Polycythemia vera (PV) is a myeloproliferative neoplasm affecting >100,000 people in the United States annually. Patients (pts) with PV are at risk for thromboembolic events (TEs), premature death, and high symptom burden. Hydroxyurea (HU)
Autor:
Tevriz Dilan Demir, Ayca Sayi-Yazgan, Umit Ince, Sinem Oktem-Okullu, Nogayhan Seymen, Arzu Tiftikçi, Nurdan Tözün, Ugur Sezerman, Sawsan Sudqi Said, Fatma Tokat, Elif Merve Aydın, Bahattin Çiçek
Publikováno v:
Immunology Letters. 239:1-11
Background The progression to gastric cancer has been linked to chronic infection with Helicobacter pylori (H. pylori). Immune checkpoint inhibitors (programmed cell death -1, PD-1; programmed cell death –ligand 1, PD-L1) have a role in cancer immu
Autor:
Wen-Jie Luo, Dingwei Ye, Yongqiang Huang, Yuan-Yuan Qu, Wenhao Xu, Mengfei Yao, Jun Wang, Chunguang Ma, Yiping Zhu, Hailiang Zhang, Fangning Wan
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-11 (2021)
Cell Death & Disease
Cell Death & Disease
Long non-coding RNAs (lncRNAs) act as important regulators of tumorigenesis and development in bladder cancer. However, the underlying molecular mechanisms remain elusive. We previously identified a novel lncRNA signature related to immunity and prog
Autor:
Zhigang Tian, Xiaokun Shen, Rui Sun, Chuang Guo, Binqing Fu, Haiming Wei, Jiabin Li, Dongyao Wang, Ying Ye, Junfei Zhang, Yanyan Liu
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-13 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Patients with chronic hepatitis B (CHB) undergoing interferon (IFN)-α-based therapies often exhibit a poor HBeAg serological response. Thus, there is an unmet need for new therapies aimed at CHB. This study comprised two clinical trials, including 1
Autor:
Michelle Krogsgaard, Iman Osman, Janice M. Mehnert, Jeffrey S. Weber, Nicholas Gulati, Arda Celen, Judy Zhong, Paul Johannet
Publikováno v:
Cancer Medicine, Vol 10, Iss 21, Pp 7457-7465 (2021)
Cancer Medicine
Cancer Medicine
Background Immune‐related adverse events (irAEs) are common, clinically significant autoinflammatory toxicities observed with immune checkpoint inhibitors (ICI). Preexisting immune‐mediated inflammatory disease (pre‐IMID) is considered a relati
Publikováno v:
Immunology Letters. 239:23-31
The polarization of macrophages plays a critical role in the pathophysiology of rheumatoid arthritis. The macrophages can have pro-inflammatory M1 polarization and various types of alternative anti-inflammatory M2 polarization. Our preliminary result
Autor:
Babak PeyroShabany, Mansoureh Dehghani, Seyed Alireza Javadinia, Danial Fazilat-Panah, Pejman Porouhan, Farbod Hatami, James S Welsh, Maryam Nabavifard, Mona Ariamanesh, Mohammad Fereidouni
Publikováno v:
Cancer Investigation
article-version (VoR) Version of Record
article-version (VoR) Version of Record
ObjectivePatients with malignancy suffer from a compromised immune system due to either the effects of malignancies or treatments. Cancer patients are at higher risk of different infections particularly SARS-CoV2 and usually produce weaker response t