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Autor:
Ryusaku Matsumoto, Masaaki Yamamoto, Genzo Iguchi, Shin Urai, Hidenori Fukuoka, Wataru Ogawa, Kentaro Suda, Hiroki Shichi, Keitaro Kanie, Yutaka Takahashi, Hironori Bando, Yasunori Fujita
Publikováno v:
Cancer Immunology, Immunotherapy
Background Immune checkpoint inhibitors (ICIs) as a cancer immunotherapy have emerged as a treatment for multiple advanced cancer types. Because of enhanced immune responses, immune-related adverse events (irAEs), including endocrinopathies such as h
Autor:
Wen-Jie Luo, Dingwei Ye, Yongqiang Huang, Yuan-Yuan Qu, Wenhao Xu, Mengfei Yao, Jun Wang, Chunguang Ma, Yiping Zhu, Hailiang Zhang, Fangning Wan
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-11 (2021)
Cell Death & Disease
Cell Death & Disease
Long non-coding RNAs (lncRNAs) act as important regulators of tumorigenesis and development in bladder cancer. However, the underlying molecular mechanisms remain elusive. We previously identified a novel lncRNA signature related to immunity and prog
Autor:
Zhigang Tian, Xiaokun Shen, Rui Sun, Chuang Guo, Binqing Fu, Haiming Wei, Jiabin Li, Dongyao Wang, Ying Ye, Junfei Zhang, Yanyan Liu
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-13 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Patients with chronic hepatitis B (CHB) undergoing interferon (IFN)-α-based therapies often exhibit a poor HBeAg serological response. Thus, there is an unmet need for new therapies aimed at CHB. This study comprised two clinical trials, including 1
Autor:
Zeinab Albadry M. Zahran, Khalid Muhammad, Alaa Rashad, Zeinab A Abd Elhameed, Yasir Waheed, Salah M. Khallaf, Gaber El-Saber Batiha, Amal Rayan, Dalia O. Mohamed, Hanaa Nafady-Hego, Helal F Hetta, Asmaa M Zahran
Publikováno v:
Journal of Immunology Research, Vol 2021 (2021)
Journal of Immunology Research
Journal of Immunology Research
Background and Aim. Myeloid-derived suppressor cells (MDSCs) contribute to the process of malignant transformation and tumor progression through immuno- and nonimmunosuppressive mechanisms. The current study is aimed at providing the predictive and p
Autor:
Suzanne Krishfield, Elena N Cravens, Suruchi A Ramanujan, Vaishali R. Moulton, Vasileios C. Kyttaris
Publikováno v:
Arthritis & Rheumatology (Hoboken, N.j.)
Objective Autoimmune diseases affect women disproportionately more than men. Estrogen is implicated in immune cell dysfunction, yet its precise molecular roles are not fully known. We recently identified new roles for serine/arginine‐rich splicing
Autor:
Ben Barron-Millar, Andrew L. Mellor, Henrique Lemos, John D. Isaacs, Nicola J. Maney, Christopher D. Carey, Amy E. Anderson, Ian Herron, Arthur G. Pratt
Publikováno v:
Arthritis & Rheumatology. 73:1820-1830
Objective As well as being an established oncoprotein and therapeutic target in cancer, proviral integration site for Moloney murine leukemia virus 1 (Pim-1) is implicated in human autoimmunity. This study was undertaken to investigate Pim-1 and its
Autor:
Henghui Zhang, Wei Zhou, Chao Wu, Ruyan Xie, Xianchao Guo, Jun Ji, Lei Zhang, Chenhong Peng, Fei Yuan, Ying Yang, Chao Wang, Min Shi, Jun Zhang
Publikováno v:
Cancer Immunology, Immunotherapy
Objective To investigate the molecular characteristics in tumor immune microenvironment that affect long-term survival of patients with pancreatic adenocarcinoma (PAAD). Methods The tumor related genetic features of a female PAAD patient (over 13-yea
Autor:
Ben Liu, Yufan Ying, Xueyou Ma, Xiao Wang, Xiangyi Zheng, Weiyu Wang, Liping Xie, Bo Xie, Haiyun Xie, Jiangfeng Li, Jian Wu, Jiajie Fang, Shiming Chen
Publikováno v:
Cell Death and Disease, Vol 12, Iss 8, Pp 1-12 (2021)
Cell Death & Disease
Cell Death & Disease
Emerging discoveries of dynamic and reversible N6-methyladenosine (m6A) modification on RNA in mammals have revealed the key roles of the modification in human tumorigenesis. As known m6A readers, insulin-like growth factor 2 mRNA-binding proteins (I
Publikováno v:
Cell Death and Disease, Vol 12, Iss 8, Pp 1-9 (2021)
Cell Death & Disease
Cell Death & Disease
MicroRNA (miR)-361-5p has been studied to suppress gliomas development. Based on that, an insight into the regulatory mechanism of miR-361-5p in gliomas was supplemented from ubiquitin protein ligase E3 component N-recognin 5 (UBR5)-mediated ubiquiti
Autor:
Giorgio Durante, Cosimo Misciali, Martina Lambertini, Cristian Bassi, Massimo Negrini, Elisa Porcellini, Eric Londin, Mattia Riefolo, Isidore Rigoutsos, Roberta Roncarati, Phillipe Loher, Emi Dika, Annalisa Patrizi, Manuela Ferracin, Elisabetta Broseghini
Publikováno v:
Cell Death and Disease, Vol 12, Iss 5, Pp 1-15 (2021)
Cell Death & Disease
Cell Death & Disease
Malignant cutaneous melanoma (CM) is a potentially lethal form of skin cancer whose worldwide incidence has been constantly increasing over the past decades. During their lifetime, about 8% of CM patients will develop multiple primary melanomas (MPMs