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Autor:
Young Suk Park, Sun-Ju Byeon, Su Jin Lee, Ho Yeong Lim, Se Hoon Park, Kyoung-Mee Kim, Won Ki Kang, Jeeyun Lee, Joon Oh Park, Seung Tae Kim
Publikováno v:
Journal of Immunotherapy. 42:279-283
We performed a prospective immunohistochemical analysis of lymphocyte activation gene 3 (LAG3) for 430 consecutive patients with advanced gastrointestinal, genitourinary, or rare cancers between June 2012 and March 2016. Most patients (428/430, 99.5%
Autor:
Karim Bahmed, Hsin Yao Tang, Jiusheng Lin, Tessa Andrews, Samia Boukhenouna, Robert John Mason, Loukmane Karim, Elise M. Messier, Gerard J. Criner, Robert Powers, Mark A. Wilson, Roger Powell, Chih-Ru Lin, Beata Kosmider, Nichole Reisdorph
Publikováno v:
Cell Death and Disease, Vol 10, Iss 9, Pp 1-14 (2019)
Cell Death & Disease
Cell Death & Disease
DJ-1 is a multifunctional protein with cytoprotective functions. It is localized in the cytoplasm, nucleus, and mitochondria. The conserved cysteine residue at position 106 (Cys106) within DJ-1 serves as a sensor of redox state and can be oxidized to
Autor:
Wentao Fang, Chia-Hsin Wu, Qiang-Ling Sun, Zhi-Tao Gu, Lei Zhu, Teng Mao, Xue-Fei Zhang, Ning Xu, Tzu-Pin Lu, Mong-Hsun Tsai, Li-Han Chen, Liang-Chuan Lai, Eric Y. Chuang
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, Vol 12 (2021)
Thymic carcinoma (TC) is the most aggressive thymic epithelial neoplasm. TC patients with microsatellite instability, whole-genome doubling, or alternative tumor-specific antigens from gene fusion are most likely to benefit from immunotherapies. Howe
Autor:
Zhengang Hu, Hao Zhang, Fan Fan, Zeyu Wang, Jiahao Xu, Yunying Huang, Ziyu Dai, Hui Cao, Xun Zhang, Zhixiong Liu, Quan Cheng
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
Frontiers in Immunology
DNA methylation patterns are essential in understanding carcinogenesis. However, the relationship between DNA methylation and the immune process has not been clearly established—this study aimed at elucidating the interaction between glioma and DNA
Autor:
Jingdong Zhang, Yang Shao, Yan Shi, Xue Li, Shiqing Chen, Lan-Lan Pan, Yunpeng Liu, Fengjiao Zhao, Haizhou Lou, Dongqin Zhu, Zhaoxia Wang, Yongqian Shu, Jing Liu, Jieer Ying, Deqiang Wang, Xiaofeng Chen, Jun Zhou, Liuqing Zhu, Jingrong Qiu, Jianyi Zhao, Xiangcheng Li, Jiuwei Cui
Publikováno v:
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 11 (2021)
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 11 (2021)
BackgroundRecently, immunotherapy with immune checkpoint inhibitors (ICIs) has shown promising efficacy in biliary tract cancer (BTC), which includes gallbladder cancer (GBC) and cholangiocarcinoma (CHOL). Understanding the association between immuno
Autor:
Xincheng Wu, Zhengping Bai
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Epigenetic modifications, especially N6-methyladenosine (m6A) modification, play a key role in tumor microenvironment (TME) infiltration. However, the regulatory role of m6A modification in the TME of lung adenocarcinoma (LUAD) remains unclear. A tot
Autor:
Sheng Wang, Qian Song, Lin Meng, Yutian Zheng, Jun-zhou Wu, Shenyi Lian, Qian Yao, Zhongwu Li
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
Frontiers in Immunology
PTP4A3 plays an important role in the tumorigenesis and metastasis of multiple tumors, but its prognostic role in renal cancer is not well understood. We utilized the Oncomine and Tumor Immunoassay Resource databases to examine the differential expre
Autor:
Benjamin L. Ebert, David M. Evans, Mridul Agrawal, Veronica Shkolnik, Douglas P. Kiel, Christopher J. Gibson, Marie McConkey, Mesbah Uddin, Wesley J. Shin, Abhishek Niroula, Drew N. Cohen, James P. Pirruccello, Pradeep Natarajan, Mikolaj Slabicki, Mary L. Bouxsein, Alexander G. Bick, Waihay J. Wong, Gabriel K. Griffin, Daniel J. Brooks, Peter Geon Kim, Aswin Sekar, Julia F. Charles, J. Brent Richards, Amy E. Lin, Jonathan M. Tsai, Marc N. Wein, John P. Kemp, Siddhartha Jaiswal
Publikováno v:
The Journal of experimental medicine. 218(12)
Osteoporosis is caused by an imbalance of osteoclasts and osteoblasts, occurring in close proximity to hematopoietic cells in the bone marrow. Recurrent somatic mutations that lead to an expanded population of mutant blood cells is termed clonal hema
Autor:
Sang T. Kim, Elliot Norry, Jean Tayar, Amy Sun, Juli Miller, Danxia Ke, Siqing Fu, David S. Hong
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 7 (2021)
Journal for Immunotherapy of Cancer
Journal for Immunotherapy of Cancer
With durable cancer responses, genetically modified cell therapies are being implemented in various cancers. However, these immune effector cell therapies can cause toxicities, including cytokine release syndrome (CRS) and immune effector cell-associ
Autor:
Genevieve J. Kaunitz, Janis M. Taube, Boyang Zhang, Poromendro Burman, Tricia R. Cottrell, Hongkai Ji, Jody E. Hooper, Mohamad E. Allaf, Franco Verde, Hans J. Hammers, Jiajia Zhang, Kellie N. Smith, Hok Yee Chan
Publikováno v:
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 7 (2021)
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 7 (2021)
T-cell receptor sequencing (TCRseq) enables tracking of T-cell clonotypes recognizing the same antigen over time and across biological compartments. TCRseq has been used to test if cross-reactive antitumor T cells are responsible for development of i