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Autor:
Charles L, Vogel, Melody A, Cobleigh, Debu, Tripathy, John C, Gutheil, Lyndsay N, Harris, Louis, Fehrenbacher, Dennis J, Slamon, Maureen, Murphy, William F, Novotny, Michael, Burchmore, Steven, Shak, Stanford J, Stewart, Michael, Press
Publikováno v:
Journal of Clinical Oncology. 41:1638-1645
PURPOSE To evaluate the efficacy and safety of first-line, single-agent trastuzumab in women with HER2-overexpressing metastatic breast cancer. PATIENTS AND METHODS One hundred fourteen women with HER2-overexpressing metastatic breast cancer were ran
Publikováno v:
Journal of Clinical Oncology. 41:1331-1338
PURPOSE Immunohistochemistry (IHC) is a newer technique for assessing the estrogen receptor (ER) status of breast cancers, with the potential to overcome many of the shortcomings associated with the traditional ligand-binding assay (LBA). The purpose
Autor:
Paul Mitchell, G Rivalland, Hui Yu, Fred R. Hirsch, R. Mosher, L Churilov, K Asadi, Christopher J. Rivard, S Heynemann
Publikováno v:
Clinical Lung Cancer. 23:e90-e98
Background NaPi2b is a multi-transmembrane sodium-dependent phosphate transporter expressed at normal levels in several organs, including lung. High expression levels have been reported in various tumours including breast, thyroid, ovarian and non-sm
Autor:
Sebastian F. Schoppmann, Emmanuella Guenova, Gerd Jomrich, Matthias Preusser, Robin Ristl, Dariga Ramazanova, Aysegül Ilhan-Mutlu, Richard Grose, Christina Fassnacht, Dagmar Kollmann, Yi-Chien Tsai
Publikováno v:
European Journal of Surgical Oncology. 48:383-390
The effects of cytotoxic chemotherapy on the expression of programmed cell death 1 (PD-1) and its ligand (PD-L1) in cancer cells and peritumoral cells are unclear. The aim of this study was to investigate the impact of neoadjuvant chemotherapy on PD-
Autor:
Joseph, Kattan, Fady El, Karak, Fadi, Farhat, Dany Abi, Gerges, Walid, Mokaddem, Georges, Chahine, Saad, Khairallah, Najla, Fakhruddin, Jawad, Makarem, Fadi, Nasr
Publikováno v:
BMC Cancer
BMC Cancer, 2022, 22 (1), pp.1114. ⟨10.1186/s12885-022-10206-1⟩
BMC Cancer, 2022, 22 (1), pp.1114. ⟨10.1186/s12885-022-10206-1⟩
Background This study aimed to report the prevalence of HER2-neu in newly diagnosed early or metastatic gastric cancer (GC) patients, to determine the percentage of patients achieving various IHC scores correlating with the ISH results and to establi
Autor:
Astrid Louise Bjørn Bennedsen, Luyi Cai, Rune Petring Hasselager, Aysun Avci Özcan, Khadra Bashir Mohamed, Jens Ole Eriksen, Susanne Eiholm, Michael Bzorek, Anne-Marie Kanstrup Fiehn, Thomas Vauvert F. Hviid, Ismail Gögenur
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-19 (2022)
Bennedsen, A L B, Cai, L, Hasselager, R P, Özcan, A A, Mohamed, K B, Eriksen, J O, Eiholm, S, Bzorek, M, Fiehn, A-M K, Hviid, T V F & Gögenur, I 2022, ' An exploration of immunohistochemistry-based prognostic markers in patients undergoing curative resections for colon cancer ', BMC Cancer, vol. 22, 62 . https://doi.org/10.1186/s12885-022-09169-0
BMC Cancer
Bennedsen, A L B, Cai, L, Hasselager, R P, Özcan, A A, Mohamed, K B, Eriksen, J O, Eiholm, S, Bzorek, M, Fiehn, A-M K, Hviid, T V F & Gögenur, I 2022, ' An exploration of immunohistochemistry-based prognostic markers in patients undergoing curative resections for colon cancer ', BMC Cancer, vol. 22, 62 . https://doi.org/10.1186/s12885-022-09169-0
BMC Cancer
Background The immune system recognizes and destroys cancer cells. However, cancer cells develop mechanisms to avoid detection by expressing cell surface proteins. Specific tumour cell surface proteins (e.g. HLA-G, PD-L1, CDX2) either alone or in com
Publikováno v:
Cancer Medicine, Vol 11, Iss 2, Pp 492-506 (2022)
Cancer Medicine
Cancer Medicine
Background and Aims Cancer‐associated stroma (CAS) is emerging as a key determinant of metastasis in colorectal cancer (CRC); however, little is known about CAS in colorectal liver metastases (CRLM). This study aimed to validate the prognostic sign
Publikováno v:
European Journal of Surgical Oncology. 48:211-217
Background Microsatellite instability, programmed death-ligand 1 and tumor-infiltrating leukocytes are prognostic biomarkers in colorectal cancer but unknown toward familial adenomatous polyposis. Aim To investigate the prognostic and clinicopatholog
Publikováno v:
Journal of Cancer Research and Clinical Oncology
Propose Laryngeal chondrosarcoma is a rare non-epithelial malignant tumor. At present, the cell type composition and molecular mechanism of laryngeal chondrosarcoma have not been systematically studied. Methods This study focused on the histopatholog
Autor:
Dirk Andreas Ridder, Arndt Weinmann, Mario Schindeldecker, Lana Louisa Urbansky, Kristina Berndt, Tiemo Sven Gerber, Hauke Lang, Johannes Lotz, Karl J. Lackner, Wilfried Roth, Beate Katharina Straub
Publikováno v:
International Journal of Cancer. 150:1053-1066
Alpha fetoprotein (AFP) is the most widely used diagnostic and prognostic serum biomarker for hepatocellular carcinoma (HCC). Despite its wide clinical use, a systematic clinicopathologic study comparing AFP expression in HCC in situ with serum AFP c