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Targeting CXCR2 inhibits the progression of lung cancer and promotes therapeutic effect of cisplatin
Autor:
Yuan Cheng, Xuejiao Han, Qingfang Li, Fei Mo, Xiawei Wei, Yuquan Wei, Houhui Shi, Siyuan Chen
Publikováno v:
Molecular Cancer, Vol 20, Iss 1, Pp 1-21 (2021)
Molecular Cancer
Molecular Cancer
Background Drug-resistance and severe side effects of chemotherapeutic agents result in unsatisfied survival of patients with lung cancer. CXCLs/CXCR2 axis plays an important role in progression of cancer including lung cancer. However, the specific
Tertiary lymphoid structures show infiltration of effective tumor‐resident T cells in gastric cancer
Autor:
Yoshihito Yamakoshi, Yuichiro Miki, Mami Yoshii, Sota Deguchi, Shugo Suzuki, Takuya Mori, Tatsuro Tamura, Kazuya Muguruma, Takahiro Toyokawa, Shigeru Lee, Masaichi Ohira, Hideki Wanibuchi, Hiroaki Tanaka
Publikováno v:
Cancer Science
Several studies have reported that tissue‐resident memory T cells (TRM cells) or tertiary lymphoid structures (TLSs) are associated with a good prognosis. The aim of this study was to clarify the association of TRM cells and TLSs in the tumor immun
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-11 (2021)
BMC Cancer
BMC Cancer
BackgroundThe purpose of this retrospective study was to evaluate the survival outcomes of pembrolizumab (PEM) plus enzalutamide (ENZ) versus PEM alone in selected populations of men with previously untreated metastatic castration-resistant prostate
Autor:
Masanori Hayashi, Tetsuro Yamagishi, Chihaya Imai, Hajime Umezu, Takashi Ariizumi, Yudai Murayama, Akira Ogose, Naoki Oike, Hiroyuki Kawashima, Hiroshi Hatano, Naoto Endo
Publikováno v:
Cancer Immunology, Immunotherapy
The characteristics of the tumor immune microenvironment remains unclear in liposarcomas, and here we aimed to determine the prognostic impact of the tumor immune microenvironment across separate liposarcomas subtypes. A total of 70 liposarcoma patie
Publikováno v:
Anticancer Research. 41:2079-2082
Background/aim Inflammatory pseudotumors are complex entities given that they carry varying characteristics with a multitude of behaviors that can resemble a malignancy clinically, radiographically, and histologically. Patients and methods Our case r
Autor:
Yalei Chen, Benjamin A. Rybicki, Kevin R. Bobbitt, K Arora, Watchareepohn Palangmonthip, Dhananjay Chitale, Sudha M. Sadasivan, Deliang Tang, Nilesh S. Gupta, Andrew Rundle, Oleksandr Kravtsov, Sean R Williamson, Kenneth A. Iczkowski
Publikováno v:
Cancer Medicine, Vol 10, Iss 9, Pp 3013-3025 (2021)
Cancer Medicine
Cancer Medicine
Growth and differentiation factor 15 (GDF‐15), also known as macrophage inhibitory cytokine 1 (MIC‐1), may act as both a tumor suppressor and promotor and, by regulating NF‐κB and macrophage signaling, promote early prostate carcinogenesis. To
Autor:
Audrey J. Lazenby, Chandrakanth Are, Lynette M. Smith, Michael G. Brattain, Premila D. Leiphrakpam
Publikováno v:
Journal of Surgical Oncology. 123:1764-1772
OBJECTIVES To evaluate the relationship between stathmin expression and clinical outcome in colorectal cancer (CRC). BACKGROUND Stathmin is a phosphoprotein involved in the regulation of microtubule dynamics and integration of intracellular signaling
Autor:
Zenan Lin, Daniela Süsskind
Publikováno v:
Journal of Cancer Research and Clinical Oncology. 147:1389-1405
While B-cell activating factor (BAFF) was identified to promote the invasion in other malignancies, its role in the progression of uveal melanoma (UM) still remains unexplored. Here, we analysed the serum level of BAFF in UM patients with regard to i
Autor:
Thomas Karn, Friederike Hoellen, Uwe Holtrich, Stefan Kommoss, Achim Rody, Heidrun Gevensleben, David G. Huntsman, Z Drosos, Michael S. Anglesio, M Graeser-Mayer, Lars Hanker, G Gitas, Ahmed El-Balat
Publikováno v:
Journal of Cancer Research and Clinical Oncology
Purpose Sphingosine-kinase-1 (SPHK1) is a key enzyme of sphingolipid metabolism which is involved in ovarian cancer pathogenesis, progression and mechanisms of drug resistance. It is overexpressed in a variety of cancer subtypes. We investigated SPHK
Autor:
Jae Seog Hyun, Dong Chul Kim, Min Ho Lee, See Min Choi, Jong Sil Lee, Seong Uk Jeh, Chunwoo Lee, Sin Woo Lee, Jeong Seok Hwa, Sung Chul Kam, Jae Hwi Choi
Publikováno v:
Anticancer Research. 41:1377-1386
BACKGROUND/AIM The purpose of this study was to examine the expression of estrogen receptor α (ERα) and β (ERβ), androgen receptor (AR), SIRT1, SIRT2 and SIRT3 in prostate cancer (PCa). MATERIALS AND METHODS From October 2010 to January 2015, 70