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Autor:
Sang Jun Ha, Daehee Hwang, Eun Chang Choi, Min Hee Hong, Se-Heon Kim, Hye Ryun Kim, Sun Min Lim, Sun Och Yoon, Da Hee Kim, Yoon Woo Koh, Sehyun Chae
Publikováno v:
Journal of Cancer Research and Clinical Oncology. 147:2741-2750
We aimed to investigate the prognostic value of multiple immune cell markers including programmed death-ligand 1 (PD-L1) and poliovirus receptor (PVR) in head and neck squamous cell carcinoma (HNSCC) using archival tumor tissues METHODS: Patients dia
Publikováno v:
Cancer Biomarkers. 30:193-201
BACKGROUND: Contactin1 (CNTN1), a member of the immunoglobulin superfamily, is known to correlate with tumor development and progression. Although recent studies have found that elevated CNTN1 has been demonstrated in some types of cancers, the expre
Autor:
Weibin Hou, Jian Huang, Kun Xia, Meihua Yang, Meng Yang, Junyu Chen, Bo Wang, Tianxin Lin, Wenlong Zhong, Bingkun Zhou, Xiaofei Wang, Hao Yu
Publikováno v:
Cancer Immunology, Immunotherapy. 70:2657-2668
The expression status of programmed cell death-ligand 1/programmed cell death 1 (PD-L1/PD-1) and the infiltration of CD8+ T cells in tumor tissues are considered to be related to immunotherapy efficacy and patient prognosis. The purpose of this study
Autor:
Rajiv M. Patel, Jae Eun Choi, Douglas R. Fullen, Nallasivam Palanisamy, Tasha M. Hughes, Bryan Johnson, Xiaoming Wang, Christopher K. Bichakjian, May P. Chan, Javed Siddiqui, Lili Zhao, Shannon Carskadon, Josh N. Vo, Steven M. Hrycaj, Kelly L. Harms, Scott A. Tomlins, Rahul Mannan, Scott A. McLean, Vincent T. Ma, Daniel R. Rhodes, Paul W. Harms
Publikováno v:
Clin Cancer Res
Purpose: Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine carcinoma that can be divided into two classes: virus-positive (VP) MCC, associated with oncogenic Merkel cell polyomavirus (MCPyV); and virus-negative (VN) MCC, associate
Autor:
Nina L. Jebsen, Brynjar Mauseth, Ketil André Camilio, Ahmad Awada, George Lazaridis, Christiane Jungels, Hamina Patel, Aurélien Marabelle, Vibeke Sundvold, Fabienne Hermitte, Delphine Loirat, James Spicer, Øystein Rekdal, Berit Nicolaisen, R Kristeleit, Paal Brunsvig, Andrew Saunders, Dag Erik Jøssang, Jérôme Galon, Baldur Sveinbjørnsson, Jean Francois Baurain
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. xx, no.xx, p. xx (2021)
Purpose: LTX-315 is a first-in-class, 9-mer membranolytic peptide that has shown potent immunomodulatory properties in preclinical models. We conducted a phase I dose-escalating study of intratumoral LTX-315 administration in patients with advanced s
Autor:
Junyi Ye, Shanai Song, Haiwei Du, Zhou Zhang, Haiyan Li, Ning Liu, Zimin Liu, Xiaoxiao Li, Lu Zhang, Mingpeng Shi
Publikováno v:
Journal of Cancer Research and Clinical Oncology
Purpose The identification of HER2 overexpression in a subset of gastric adenocarcinoma (GA) patients represents a significant step forward in unveiling the molecular complexity of this disease. The predictive and prognostic value of HER2 amplificati
Autor:
Jang-Hee Kim, Sun Il Kim, Bumhee Park, Se Joong Kim, Nam Hoon Cho, Seol Ho Choo, Ji Su Kim, Jiyeon Han, Ji Eun Kwon, Sang Kyum Kim
Publikováno v:
Journal of Cancer Research and Clinical Oncology
BackgroundPenile carcinoma is a rare malignant neoplasm and its molecular pathogenetic mechanism is largely unknown. Telomerase reverse transcriptase (TERT) promoter mutations have been detected in several types of human malignancies, including malig
Autor:
Mark E. Burkard, Daniel R. Matson, Ryan A. Denu, Lauren M. Zasadil, Christopher Flynn, P. Todd Stukenberg, Beth A. Weaver
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-11 (2021)
BMC Cancer
BMC Cancer
Background Targeting Protein for Xenopus Kinesin Like Protein 2 (TPX2) is a microtubule associated protein that functions in mitotic spindle assembly. TPX2 also localizes to the nucleus where it functions in DNA damage repair during S-phase. We and o
Autor:
Majd Jundi, Fatemeh Saheb Sharif-Askari, Kari Syrjänen, Riyad Bendardaf, Rifat Hamoudi, Surendra Rawat, Narjes Saheb Sharif-Askari, Noura Alkhayyal, Iman M. Talaat
Publikováno v:
Anticancer Research. 41:739-745
BACKGROUND/AIM Limited data exist on the expression pattern of TNFAIP3/A20, as assayed by immunohistochemistry (IHC), in breast cancer tissues. This study aimed to assess A20 expression pattern in breast cancer. MATERIALS AND METHODS The expression o
Autor:
Tomio Arai, Hideyuki Ishida, Erito Mochiki, Minoru Fukuchi, Tatsuro Yamaguchi, Kiwamu Akagi, Okihide Suzuki
Publikováno v:
Anticancer Research. 41:975-982
Background/aim DNA mismatch repair (MMR) deficiency has received increasing attention as a biomarker of anti-PD-1 treatments of solid tumors including gastric cancer (GC). However, efficient screening has not been established. Patients and methods A