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Autor:
Mingxiao Li, Weiwei Zhang, Xuzhe Zhao, Chuanwei Yang, Hongyan Chen, Ming Li, Lin Song, Kefu Yu, Xiaohui Ren, Gehong Dong, Haihui Jiang, Yong Cui, Qinghui Zhu
Publikováno v:
Cancer Science
Pyrosequencing (PSQ) represents the golden standard for MGMT promoter status determination. Binary interpretation of results based on the threshold from the average of several CpGs tested would neglect the existence of the “gray zone”. How to def
Autor:
Kai Bachmann, Tarik Ghadban, Ronald Simon, Nathaniel Melling, Claudia Hube-Magg, Eugen Bellon, Michael Tachezy, Katharina Grupp, Jakob R. Izbicki, Guido Sauter
Publikováno v:
Journal of Cancer Research and Clinical Oncology
Introduction Lysophosphatidylcholine acyltransferase 1 (LPCAT1) has repeatedly been suggested to be associated with tumorigenesis. To evaluate the role of LPCAT1 in esophageal cancer, LPCAT1 immunostaining was analyzed on a tissue microarray containi
Autor:
Miki Nagatsuka, Seiichiro Masui, Miwako K. Homma, Yuichiro Kiko, Yoshimi Homma, Naoto Katagata, Yuko Hashimoto, Tadashi Nomizu
Publikováno v:
Cancer Science
Overexpression of the ubiquitous protein kinase, CK2α, has been reported in various human cancers. Here, we demonstrate that nuclear and nucleolar CK2α localization in invasive ductal carcinomas of the breast is a reliable predictor of poor prognos
Publikováno v:
Diagnostic Pathology, Vol 16, Iss 1, Pp 1-9 (2021)
Diagnostic Pathology
Diagnostic Pathology
Background Gastric cancer (GCa) is one of the six major malignancies in the world with low survival rate. Although there are advances in therapeutic approaches, the prognosis of patients with GCa remains not optimistic. Therefore, this study aimed to
Autor:
PrzemysŁaw Biecek, Jolanta OrŁowska-Heitzmann, Anna Markiewicz, BoŻena Romanowska-Dixon, Martyna Elas, Piotr Donizy
Publikováno v:
Anticancer Research. 41:517-526
AIM The evaluation of the prognostic role of nuclear pseudoinclusions (NPIs) and nuclear grooves (NGs) in UM. PATIENTS AND METHODS We examined the presence of NPIs and NGs in hematoxylin and eosin-stained tissue sections from 164 removed eyeballs wit
Autor:
Yusuke Shinchi, Daiki Yoshii, Koei Ikeda, Makoto Suzuki, Takuro Sakagami, Yoshihiro Komohara, Yusuke Tomita, Eri Matsubara, Kensaku Sato, Yukio Fujiwara, Koji Ohnishi, Remi Mito
Publikováno v:
Pathology International. 70:287-294
Tumor-associated calcium signal transducer 2 (TROP2) is a cell-surface glycoprotein involved in the high malignant potential of several cancers. Antibody-drug conjugates that target TROP2 represent a promising approach for the treatment of TROP2-expr
Autor:
Claire Danel, Aurélie Sannier, Jean-Michel Rodier, Anne Couvelard, S. Brosseau, Hussein Nassereddine, Aurélie Cazes, Antoine Khalil, Simon Msika, Nathalie Théou-Anton
Publikováno v:
Pathology & Oncology Research. 26:2795-2800
To retrospectively characterize the molecular features of Non-Small Cell Lung Carcinomas (NSCLC) with peritoneal carcinomatosis (PC), clinicopathological data of 12 patients diagnosed with NSCLC and PC between 2007 and 2016 were collected. Immunohist
Autor:
Satoshi Fujii, Hiroshi Nakamura, Masato Sugano, Takeshi Kuwata, Tomohiro Miyoshi, Shinya Katsumata, Norihiko Ikeda, Tomokazu Omori, Atsushi Ochiai, Genichiro Ishii, Motohiro Kojima, Keiju Aokage, Masahiro Tsuboi
Publikováno v:
Journal of Cancer Research and Clinical Oncology. 145:1773-1783
The growth pattern of peripheral squamous cell carcinoma (SCC) of the lung is divided into two types: alveolar space-filling (ASF) growth and alveolar space-destructive (ASD) growth. The aim of this study was to investigate the clinicopathological di
Autor:
Ilona Kovalszky, Benedek Gyöngyösi, András Kiss, Klára Werling, Zsuzsa Schaff, Endre Kontsek, Attila Patonai, Krisztina Schlachter, Adrián Pesti, Gábor Lendvai, Tímea Szekerczés
Publikováno v:
Pathology & Oncology Research. 25:1103-1109
The liver disease focal nodular hyperplasia (FNH) has several histological features that resemble hepatic cirrhosis. Since cirrhosis may develop further into hepatocellular carcinoma (HCC) contrary to FNH, the aim of the present study was to identify
Autor:
Zhimei Zhang, Hui Ren, Ertao Zhai, Weigang Dai, Jinning Ye, Shirong Cai, Liang Yang, Hui Wu, Yulong He, Jieyi Ma, Jianhui Chen
Publikováno v:
Diagnostic Pathology, Vol 13, Iss 1, Pp 1-9 (2018)
Diagnostic Pathology
Diagnostic Pathology
Background Heat shock factor 1 (HSF1) was initially identified as a transcription factor encoding heat shock proteins, which assist in refolding or degrading damaged proteins. Recent studies have reported that HSF1 can act as an oncogene that regulat