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Autor:
Ashish Panigrahi, Constantine S. Tam, Piers Blombery, Xiangting Chen, John F. Seymour, Dennis A. Carney, Andrew H. Wei, Thomas E Lew, Mary Ann Anderson, Andrew W. Roberts, Ella R. Thompson, David C. S. Huang, Tamia Nguyen, David Westerman, Michael A. Dengler, Victor S Lin, Sasanka M. Handunnetti, Jerry M. Adams
Publikováno v:
Blood. 139:1198-1207
The BCL2 inhibitor venetoclax has established therapeutic roles in chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML). As BCL2 is an important determinant of survival of both myeloid progenitor and B cells, we investigated whether cl
Autor:
Liang Zhao, L. Green, T. Dougan, Haesook T. Kim, Christopher D. Gocke, J. Tsuji, Madeleine Duran, Siqing Wang, Amy E. DeZern, Brendan Blumenstiel, Sarah Nikiforow, Richard J. Jones, Niall J. Lennon, Yi-Bin Chen, Mark Fleharty, Christopher J. Gibson, Lukasz P. Gondek, Alana F. Ogata, David R. Walt, Vincent T. Ho, Chi-An Cheng, R. C. Lindsley, Jerome Ritz, Rafael Madero-Marroquin, H. M. Murdock, Joseph H. Antin, Bryan C. Hambley, Robert J. Soiffer, Carrie Cibulskis
Publikováno v:
Journal of Clinical Oncology. 40:189-201
PURPOSEClonal hematopoiesis (CH) can be transmitted from a donor to a recipient during allogeneic hematopoietic cell transplantation. Exclusion of candidate donors with CH is controversial since its impact on recipient outcomes and graft alloimmune f
Autor:
Ryusaku Matsumoto, Masaaki Yamamoto, Genzo Iguchi, Shin Urai, Hidenori Fukuoka, Wataru Ogawa, Kentaro Suda, Hiroki Shichi, Keitaro Kanie, Yutaka Takahashi, Hironori Bando, Yasunori Fujita
Publikováno v:
Cancer Immunology, Immunotherapy
Background Immune checkpoint inhibitors (ICIs) as a cancer immunotherapy have emerged as a treatment for multiple advanced cancer types. Because of enhanced immune responses, immune-related adverse events (irAEs), including endocrinopathies such as h
Autor:
Jinping Gao, Gang Chen, Yujun Sheng, Xing Fan, Ze Guo, Liangdan Sun, He Huang, Xianfa Tang, Hui Cheng, Huayang Tang, Xiaodong Zheng, Wenjun Wang
Publikováno v:
Immunology Letters. 240:98-105
Psoriasis is an immune-mediated genetic disease involving innate and the adaptive immune system. Aurora kinase A (AURKA) belongs to a seine/threonine kinases family and is elevated in lesional psoriatic tissues. This research aimed to investigate the
Publikováno v:
Human Immunology. 82:950-959
Background Right-sided colorectal cancer (RCRC) and left-sided colorectal cancer (LCRC) harbor different genetic alterations associated with immune response. Objective This study aimed to analyze the differences in T cell immune-related RNA expressio
Autor:
Beiping Zhong, Bing Cheng, Xiaoming Huang, Qian Xiao, Zhitong Niu, Yu-feng Chen, Qiang Yu, Wenyu Wang, Xiao-Jian Wu
Publikováno v:
Cell Death and Disease, Vol 13, Iss 1, Pp 1-15 (2021)
Cell Death & Disease
Cell Death & Disease
Cancer-associated fibroblasts (CAFs) have been shown to play a strong role in colorectal cancer metastasis, yet the underlying mechanism remains to be fully elucidated. Using CRC clinical samples together with ex vivo CAFs-CRC co-culture models, we f
Autor:
Kimia Sobhani, Jennifer E. Van Eyk, James L. Stewart, Warren G. Tourtellotte, Justin Darrah, Joslyn Foley, Wendy Cozen, Karen L. Reckamp, Susan Cheng, Alain C. Mita, So Yung Choi, Carissa A. Huynh, Noah Merin, Sandy Joung, Tucker Lemos, Robert Vescio, Ronald Paquette, Dermot P.B. McGovern, Edwin C. Frias, John Prostko, Omid Hamid, Joseph E. Ebinger, Emebet Mengesha, Reva Basho, Greg Botwin, Jun Gong, Nathalie Nguyen, Jonathan Braun, Inderjit Mehmi, Jane C. Figueiredo, Akil Merchant, Gil Y. Melmed, Laurel J Finster
Publikováno v:
Cancer Res
Longitudinal studies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine-induced immune responses in patients with cancer are needed to optimize clinical care. In a prospective cohort study of 366 (291 vaccinated) patients, we mea
Autor:
Philomena Colucci, Jingbo Yu, Jonathan Kish, Dilan Paranagama, Shreekant Parasuraman, Kevin C Lord, Ivy Altomare
Publikováno v:
Clinical Lymphoma Myeloma and Leukemia. 21:e915-e921
Background Polycythemia vera (PV) is a myeloproliferative neoplasm affecting >100,000 people in the United States annually. Patients (pts) with PV are at risk for thromboembolic events (TEs), premature death, and high symptom burden. Hydroxyurea (HU)
Autor:
Tevriz Dilan Demir, Ayca Sayi-Yazgan, Umit Ince, Sinem Oktem-Okullu, Nogayhan Seymen, Arzu Tiftikçi, Nurdan Tözün, Ugur Sezerman, Sawsan Sudqi Said, Fatma Tokat, Elif Merve Aydın, Bahattin Çiçek
Publikováno v:
Immunology Letters. 239:1-11
Background The progression to gastric cancer has been linked to chronic infection with Helicobacter pylori (H. pylori). Immune checkpoint inhibitors (programmed cell death -1, PD-1; programmed cell death –ligand 1, PD-L1) have a role in cancer immu
Autor:
Wen-Jie Luo, Dingwei Ye, Yongqiang Huang, Yuan-Yuan Qu, Wenhao Xu, Mengfei Yao, Jun Wang, Chunguang Ma, Yiping Zhu, Hailiang Zhang, Fangning Wan
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-11 (2021)
Cell Death & Disease
Cell Death & Disease
Long non-coding RNAs (lncRNAs) act as important regulators of tumorigenesis and development in bladder cancer. However, the underlying molecular mechanisms remain elusive. We previously identified a novel lncRNA signature related to immunity and prog