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Autor:
Astrid Louise Bjørn Bennedsen, Luyi Cai, Rune Petring Hasselager, Aysun Avci Özcan, Khadra Bashir Mohamed, Jens Ole Eriksen, Susanne Eiholm, Michael Bzorek, Anne-Marie Kanstrup Fiehn, Thomas Vauvert F. Hviid, Ismail Gögenur
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-19 (2022)
Bennedsen, A L B, Cai, L, Hasselager, R P, Özcan, A A, Mohamed, K B, Eriksen, J O, Eiholm, S, Bzorek, M, Fiehn, A-M K, Hviid, T V F & Gögenur, I 2022, ' An exploration of immunohistochemistry-based prognostic markers in patients undergoing curative resections for colon cancer ', BMC Cancer, vol. 22, 62 . https://doi.org/10.1186/s12885-022-09169-0
BMC Cancer
Bennedsen, A L B, Cai, L, Hasselager, R P, Özcan, A A, Mohamed, K B, Eriksen, J O, Eiholm, S, Bzorek, M, Fiehn, A-M K, Hviid, T V F & Gögenur, I 2022, ' An exploration of immunohistochemistry-based prognostic markers in patients undergoing curative resections for colon cancer ', BMC Cancer, vol. 22, 62 . https://doi.org/10.1186/s12885-022-09169-0
BMC Cancer
Background The immune system recognizes and destroys cancer cells. However, cancer cells develop mechanisms to avoid detection by expressing cell surface proteins. Specific tumour cell surface proteins (e.g. HLA-G, PD-L1, CDX2) either alone or in com
Autor:
Teruhisa Sakamoto, Yoichiro Tada, Shuichi Takano, Wataru Miyauchi, Kyoichi Kihara, Kazushi Hara, Toshimichi Hasegawa, Yoshiaki Matsumi, Ken Sugesawa, Manabu Yamamoto, Yoshiyuki Fujiwara, Yuji Nakayama, Akimitsu Tanio, Chihiro Uejima
Publikováno v:
Anticancer Research. 41:4857-4865
Background/aim M1 macrophages have antitumour effects, while M2 macrophages promote tumour proliferation and invasion. The clinical significance of the M2-specific marker CD204 has not been elucidated in colorectal cancer (CRC). We investigated the p
Autor:
Atanas Ignatov, Piotr Czapiewski, Thomas Kalinski, Willi Pieper, Norbert Nass, Johannes Haybaeck
Publikováno v:
Cancer Biomarkers. 32:161-173
BACKGROUND: Neuronatin (NNAT) determined by immunohistochemistry is a negative prognostic biomarker for breast cancer, independent of the major clinicopathological markers. OBJECTIVE: Here, we investigated whether NNAT is also a predictive biomarker
Autor:
Hiroshi Yagi, Yuki Masuda, Taizo Hibi, Naoto Kubota, Hidenori Ojima, Yoko Fujii-Nishimura, Yuta Abe, Masahiro Shinoda, Minoru Kitago, Yasushi Hasegawa, Go Oshima, Yuko Kitagawa, Shutaro Hori, Michiie Sakamoto, Yusuke Takemura
Publikováno v:
Cancer Medicine, Vol 10, Iss 16, Pp 5599-5613 (2021)
Cancer Medicine
Cancer Medicine
Gamma‐synuclein (SNCG) promotes invasive behavior and is reportedly a prognostic factor in a range of cancers. However, its role in biliary tract carcinoma (BTC) remains unknown. Consequently, we investigated the clinicopathological significance an
Autor:
Abdurrahman Aldiab, Ammar C. Al-Rikabi, Khalid Alsaleh, Nashwa Abd El-Aziz, Tareq Salah, Sufia Husain, Maria Arafah
Publikováno v:
Clinical Breast Cancer. 21:e362-e367
Progesterone receptor (PR), estrogen receptor (ER), and human epidermal growth factor receptor 2 (HER2) significantly influence disease prognosis and therapeutic response in patients with breast cancer. Neoadjuvant chemotherapy (NACT) can change the
Autor:
Junko Kishikawa, Hiroyuki Anzai, Soichiro Ishihara, Chieko Kitamura, Yuichiro Yokoyama, Koji Murono, Kazuhito Sasaki, Shinya Abe, Kazushige Kawai, Yuzo Nagai, Hiroaki Ishii, Shigenobu Emoto, Hiroaki Nozawa, Hirofumi Sonoda
Publikováno v:
Anticancer Research. 41:2349-2355
Background/aim Lysophosphatidylinositol (LPI) is a subspecies of the lysophospholipid mediators produced when phospholipase hydrolyzes membrane phosphatidylinositol. Previously, we used mass spectrometry-based lipidomics to demonstrate that LPI is se
Publikováno v:
Breast Disease. 40:25-31
AIM OF THE STUDY: The microenvironment depicts the relationship between tumour cells and immune response, and every insight into stromal lymphocytes could contribute to explain their role and activity. E26 transformation specific-1 (ETS-1) is a trans
Autor:
Mitsuaki Hirose, Masashi Sato, Ichinosuke Hyodo, Mamiko Imanishi, Kenji Yamato, Akinori Sugaya, Xiaoxuan Wang, Toshikazu Moriwaki, Xiaochen Zhang, Shinji Endo, Yoshiyuki Yamamoto
Publikováno v:
Anticancer Research. 41:1475-1483
Background/aim The oncoproteins murine double minute (MDM) 2 and MDM4 inactivate tumor-suppressor protein p53. Their mutual relationship with the prognosis of gastric cancer (GC) remains unknown. Patients and methods Expression of MDM2, MDM4, and p53
Publikováno v:
DNA and Cell Biology. 40:469-481
Bladder cancer (BC) is a common genitourinary malignancy worldwide. However, the molecular pathogenesis of BC remains unclear. The current study conducted bioinformatic analyses to discover key genes involved in BC progression. A total of 375 differe
Autor:
Mitsugu Sekimoto, Tomoharu Sugie, Hirotsugu Yanai, Katsuhiro Yoshikawa, Koji Tsuta, Mitsuaki Ishida
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-10 (2021)
BMC Cancer
BMC Cancer
Background Cancer-associated fibroblasts (CAFs) are some of the most abundant components of the tumour microenvironment. A recent study suggested that in some cancers, CAFs express programmed death ligand 1 (PD-L1), which can act as a prognostic mark