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Autor:
Panagiotis Sarantis, Maria Michelli, Dimitrios Schizas, Michalis V. Karamouzis, Stamatios Theoharis, Georgia Kyriakopoulou, Athanasios G. Papavassiliou, Ioanna Giannopoulou, Ilenia Chatziandreou, Evangelos Koustas, Angelica A. Saetta
Publikováno v:
American Journal of Clinical Oncology
Supplemental Digital Content is available in the text.
Objectives: Autophagy plays a dual role in tumorigenesis. In the initial stages, it promotes cell survival and suppresses carcinogenesis, whereas in cancer development, it induces cancer cel
Objectives: Autophagy plays a dual role in tumorigenesis. In the initial stages, it promotes cell survival and suppresses carcinogenesis, whereas in cancer development, it induces cancer cel
Publikováno v:
European Journal of Histochemistry : EJH
European Journal of Histochemistry, Vol 65, Iss 4 (2021)
European Journal of Histochemistry, Vol 65, Iss 4 (2021)
The primary aim of this study was to examine the correlation of the AKT/mTOR signaling pathway with the clinicopathological features and prognostic significance in nasopharyngeal carcinoma (NPC). The study tissues were collected from 285 patients wit
ER expression associates with poor prognosis in male lung squamous carcinoma after radical resection
Publikováno v:
BMC Cancer
BMC Cancer, Vol 21, Iss 1, Pp 1-13 (2021)
BMC Cancer, Vol 21, Iss 1, Pp 1-13 (2021)
Background Clinical options for lung squamous carcinoma (LUSC) are still quite limited. Carcinogenesis is an exceedingly complicated process involving multi-level dysregulations. Therefore, only looking into one layer of genomic dysregulation is far
Autor:
Lena-Christin Conradi, Tobias Lange, Stepan Nersisyan, Hanibal Bohnenberger, Ann-Kristin Ahlers, Alexander G. Tonevitsky, Sandra Genduso, Udo Schumacher, Alexei V. Galatenko, Maria Raygorodskaya, J. A. Makarova, Omar Elakad, Daniel Wicklein, D. V. Maltseva, Hanna Maar, Alina Schiecke
Publikováno v:
Biochimie. 192
In this study we analyzed expression of CD24 in a cohort of colorectal cancer patients using immunohistochemistry staining of CD24. We found a significant association between absence or low expression of CD24 (10% of membranous and 55% of cytoplasmic
Autor:
Sung Soo Kim, Minho Lee, Kwangil Yim, Jung-Sook Yoon, Eun Young Kim, Sang Hoon Chun, Hye Won Hwang, Der Sheng Sun, Su Lim Lee, Soon Auck Hong, Hye Sung Won, Yoon Ho Ko
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-12 (2021)
BMC Cancer
BMC Cancer
Background Noggin and RNA-binding protein for multiple splicing 2 (RBPMS2) are known to regulate the expression of smooth muscle cells, endothelial cells, and osteoblasts. However, the prognostic role of combined Noggin and RBPMS2 expression in resec
Autor:
Akihiko Sano, Yuki Shimoda, Hiroshi Saeki, Makoto Sakai, Keigo Hara, Makoto Sohda, Kengo Kuriyama, Nobuhiro Nakazawa, Munenori Ide, Ken Shirabe, Yasunari Ubukata, Tetsunari Oyama, Hiroomi Ogawa, Takehiko Yokobori
Publikováno v:
Oncology. 99(11)
Introduction: We investigated whether the expression of L-type amino acid transporter 1 (LAT-1) in clinical gastric cancer (GC) patients could predict patient therapeutic response to postoperative adjuvant chemotherapy. Methods: Immunohistochemistry
Autor:
Shigenori Furukawa, Takafumi Watanabe, Yuta Endo, Shu Soeda, Manabu Kojima, Hideki Chiba, Abidur Rahman, Keiya Fujimori, Yuko Hashimoto, Makoto Kobayashi, Kotaro Sugimoto
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 7
International Journal of Molecular Sciences, Vol 22, Iss 3774, p 3774 (2021)
Volume 22
Issue 7
International Journal of Molecular Sciences, Vol 22, Iss 3774, p 3774 (2021)
Background: Within the claudin (CLDN) family, CLDN12 mRNA expression is altered in various types of cancer, but its clinicopathological relevance has yet to be established due to the absence of specific antibodies (Abs) with broad applications. Metho
Autor:
Munenori Ide, Ken Shirabe, Nobuhiro Nakazawa, Seded Baatar, Makoto Sohda, Norimichi Kogure, Yasunari Ubukata, Hiroshi Saeki, Kyoichi Ogata, Akiharu Kimura, Takehiko Yokobori, Hiroyuki Kuwano
Publikováno v:
Anticancer Research. 39:4111-4116
Background/aim We investigated whether the expression of inositol 1, 4, 5-trisphosphate receptor-binding protein released with inositol 1, 4, 5-trisphosphate (IRBIT) in clinical gastric cancer (GC) patients could predict the therapeutic response to p
Publikováno v:
Journal of Oral Pathology & Medicine. 48:712-719
Background Aldo-keto reductase family 1 member B10 (AKR1B10) is an enzyme implicated in physiological xenobiotic detoxification and also in pathological carcinogenesis. Overexpression of AKR1B10 has been reported in oral squamous cell carcinoma (OSCC
Autor:
Lore Decoster, Erik Teugels, Sacha Mignon, Johan Vansteenkiste, Karen Willard-Gallo, Gert Van den Eynden, Roberto Salgado, Koen M. Marien, Jacques De Greve
Publikováno v:
Pathology and oncology research
Tumor infiltrating lymphocytes (TIL), programmed death 1 (PD-1) and programmed death-ligand 1 (PD-L1) expression are important prognostic markers. This study aimed to investigate these markers in lung adenocarcinoma (ADC) biopsies from patients with