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Autor:
Julie Means-Powell, Luis Del Valle, Vandana G. Abramson, Claudia Sorrentino, Melinda Sanders, Ingrid A. Mayer, Debra A. Tonetti, Roohi Ismail-Khan, Samarpan Majumder, Richard M Lush, Lucio Miele
Publikováno v:
Clin Breast Cancer
Preclinical studies have demonstrated a complex cross-talk between Notch and estrogen signaling in ERα-positive breast cancer. Gamma-secretase inhibitors (GSIs) are investigational agents that block the cleavage and activation of Notch receptors. In
Publikováno v:
Nitric Oxide. 118:17-25
AIMS Patients with type 2 diabetes mellitus (T2DM) have reduced vasodilatory responses during exercise partially attributable to low nitric oxide (NO) levels. Low NO contributes to greater α-adrenergic mediated vasoconstriction in contracting skelet
Publikováno v:
Plastic & Reconstructive Surgery. 148:27S-31S
Background Photoaging is premature skin aging resulting from oxidative stress generated by exposure to solar radiation. A key clinical feature is solar lentigines, areas of hyperpigmentation on sun-exposed skin. Skin pigmentation is determined by cro
Autor:
Bose Kochupurakkal, Courtney Gannon, Adrienne de Jonge, Jean-Bernard Lazaro, Sarah Kelland, Khanh T. Do, Jennifer Hedglin, Alan D. D'Andrea, Allison Powers, Kalindi Parmar, Loan Vuong, Nicholas Quinn, Geoffrey I. Shapiro
Publikováno v:
Clinical Cancer Research. 27:4710-4716
Purpose:Checkpoint kinase 1 (CHK1) plays a central role in the response to replication stress through modulation of cell-cycle checkpoints and homologous recombination (HR) repair. In BRCA-deficient cancers with de novo or acquired PARP inhibitor res
Autor:
Jing-Jing Jiang, Masaaki Murakami, Ikuma Nakagawa, Shuhei Shimoyama, Shintaro Hojyo, Osamu Ohara, Tatsuya Atsumi, Mona Uchida, Isao Matsumoto, John A. Chiorini, Mitsutoshi Ota, Yuki Tanaka, Rie Hasebe, Daisuke Kamimura, Yoshinori Hasegawa
Publikováno v:
Int Immunol
Sjögren’s syndrome (SS) is an autoimmune disease characterized by inflammation with lymphoid infiltration and destruction of the salivary glands. Although many genome-wide association studies have revealed disease-associated risk alleles, the func
Autor:
Yanshuo Cao, Lin Shen, Jiajia Yuan, Jifang Gong, Chenyu Mao, Da Jiang, Jianmin Fang, Yuxian Bai, Zhenghang Wang, Xinan Sheng, Qingxia Fan, Changsong Qi, Yi Ba, Dan Liu, Fen Yang, Yakun Wang, Yingying Xu, Zhi Peng, Ming Lu, Xiaotian Zhang, Jian Li, Xicheng Wang, Jun Zhou
Publikováno v:
Gastric Cancer
Purpose RC48 contains the novel humanized anti-HER2 antibody hertuzumab conjugated to MMAE via a cleavable linker. A phase I study was initiated to evaluate the toxicity, MTD, PK, and antitumor activity of RC48 in patients with HER2-overexpressing lo
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-5 (2021)
BMC Cancer
BMC Cancer
Background Chemotherapy induced nausea- vomiting (CINV) is considered as the most common, feared and most troublesome side effect of chemotherapy. NEPA (NEtupitant 300 mg + PAlonosetron 0.50 mg) is the first commercially available oral fixed-dose com
Autor:
Yasue Kimura, Eiji Oki, Yoshiaki Fujimoto, Masahito Kotaka, Koji Ando, Hiroyuki Kitao, Yuji Miyamoto, Masaki Mori, Ryota Nakanishi, Shichao Qiu, Yoshihiko Maehara, Mototsugu Shimokawa, Akitaka Makiyama
Publikováno v:
Cancer Science
Trifluridine/tipiracil (FTD/TPI) is an orally administrated anticancer drug with efficacy validated for patients with metastatic colorectal cancer (mCRC) or gastric cancer. FTD, a key component of FTD/TPI, exerts antitumor effects via its incorporati
Autor:
Kiran Shekar, Matthew Siuba, Leanne Parsons, George Cornmell, Mahesh Ramanan, Maneesha Tol, Sneha Varkey
Publikováno v:
Nitric Oxide. 116:35-37
Background Acute hypoxemic respiratory failure (ARF) is characterized by both lower arterial oxygen and carbon dioxide tensions in the blood. First line treatment for ARF includes oxygen therapy – intially administered non invasively using nasal pr
Publikováno v:
Inflammation. 44:1803-1814
Rheumatoid arthritis (RA) remains the most common inflammatory arthritis and a major cause of disability. This study investigated the mechanism of MLL3 in fibroblast-like synoviocyte (FLS) apoptosis and inflammatory factor secretion in RA. Expression