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Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 22
International Journal of Molecular Sciences, Vol 22, Iss 12501, p 12501 (2021)
Volume 22
Issue 22
International Journal of Molecular Sciences, Vol 22, Iss 12501, p 12501 (2021)
Seborrheic keratosis, which is a benign tumor composed of epidermal keratinocytes, develops common in the elderly. Uric acid generated by upregulated guanine deaminase (GDA) has been identified to cause UV-induced keratinocyte senescence in seborrhei
Autor:
Hiroji Iwata, Yozo Nishimura, Shigehira Saji, Min-Jung Lee, Ryoko Kimura, Jane B. Trepel, Hiroyuki Yasojima, Akihiko Shimomura, Akira Yuno, Kenji Tamura, Masataka Sawaki, Norikazu Masuda
Publikováno v:
BMC Cancer
BMC Cancer, Vol 21, Iss 1, Pp 1-12 (2021)
BMC Cancer, Vol 21, Iss 1, Pp 1-12 (2021)
Background Entinostat is an oral inhibitor of class I histone deacetylases intended for endocrine therapy-resistant patients with hormone receptor-positive (HR+) advanced or metastatic breast cancer (BC). We examined the safety, efficacy, and pharmac
Autor:
Xiaoqian Mu, Hong Wang, R. Guo, Jianying Zhou, Shengxiang Ren, Guanghui Gao, Ningqiang Ma, Yalei Zhang, Sheng Yao, Jie Zhang, Jiarui Wu, Helong Zhang, Caicun Zhou, Luonan Chen, Hui Feng, Yanjun Xu, Xiaoqing Liu, Jianxing He, Pingyang Wang, Lin Deng, Tao Jiang, Zhang Bao, Yanqiu Zhao, Yun Fan, Yongqian Shu
Publikováno v:
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-9 (2021)
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-9 (2021)
This multicenter phase-II trial aimed to investigate the efficacy, safety, and predictive biomarkers of toripalimab plus chemotherapy as second-line treatment in patients with EGFR-mutant-advanced NSCLC. Patients who failed from first-line EGFR-TKIs
Autor:
Bryan D. Young, Hannah Moreland, Zartashia Shahab, Erica L. Herzog, Francis G. Spinale, Lisa A. Freeburg, Edward J. Miller, Kelsie E. Oatmen
Publikováno v:
International heart journal. 62(5)
While cardiac imaging has improved the diagnosis and risk assessment for cardiac sarcoidosis (CS), treatment regimens have consisted of generalized heart failure therapies and non-specific anti-inflammatory regimens. The overall goal of this study wa
Autor:
Karolina Akinosoglou, Ioanna Dimopoulou, Maria Evangelidou, Vasiliki Dimakopoulou, Emmanouil Angelakis, Dionysios Fanidis, George Mpekoulis, Niki Vassilaki, Ioanna Nikitopoulou, Panagiotis Moulos, Argyris Tzouvelekis, Stylianos E. Orfanos, Konstantinos Ntatsoulis, Edison Jahaj, Vassilis Aidinis, Anastasia Kotanidou, Stamatios Tsipilis, Alice G. Vassiliou
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 18
International Journal of Molecular Sciences, Vol 22, Iss 10006, p 10006 (2021)
Volume 22
Issue 18
International Journal of Molecular Sciences, Vol 22, Iss 10006, p 10006 (2021)
Autotaxin (ATX
ENPP2) is a secreted lysophospholipase D catalyzing the extracellular production of lysophosphatidic acid (LPA), a pleiotropic signaling phospholipid. Genetic and pharmacologic studies have previously established a pathologic role
ENPP2) is a secreted lysophospholipase D catalyzing the extracellular production of lysophosphatidic acid (LPA), a pleiotropic signaling phospholipid. Genetic and pharmacologic studies have previously established a pathologic role
Publikováno v:
Journal of Clinical Laboratory Analysis
Objectives Thrombospondin 1 (THBS1) is known to play a key role in tumor metastasis, and aberrant DNA methylation is one of the mechanisms regulating THBS1. The present study investigated whether methylated THBS1 in circulating cell‐free DNA from p
Impact of lenvatinib on renal function: long-term analysis of differentiated thyroid cancer patients
Autor:
Akifumi Suzuki, Wataru Kitagawa, Keiko Ohkuwa, Reiko Ono, Chisato Tomoda, Haruhiko Yamazaki, Yoshie Hosoi, Kiyomi Y Hames, Koichi Ito, Sakiko Kobayashi, Kiminori Sugino, Mitsuji Nagahama, Chie Masaki, Junko Akaishi, Kenichi Matsuzu
Publikováno v:
BMC Cancer
BMC Cancer, Vol 21, Iss 1, Pp 1-11 (2021)
BMC Cancer, Vol 21, Iss 1, Pp 1-11 (2021)
Background Because lenvatinib is well known to induce proteinuria by blocking the vascular endothelial growth factor (VEGF) pathway, renal function is a concern with long-term administration of lenvatinib. The long-term effects of lenvatinib on renal
Autor:
Kunle Odunsi, Ronald D. Alvarez, Wiam Bshara, Premal H. Thaker, Nicholas Borys, William H. Bradley, Charles A. Leath, Khursheed Anwer, Lauren Musso, Camille Gunderson Jackson, Junko Matsuzaki
Publikováno v:
Clin Cancer Res
Purpose: GEN-1 (phIL-12-005/PPC), an IL12 plasmid formulated with polyethyleneglycol-polyethyleneimine cholesterol lipopolymer, has preclinical activity when combined with platinum-taxane intravenous chemotherapy and administered intraperitoneally in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1c5a200a6081b685a254e029db9e889
https://europepmc.org/articles/PMC9338778/
https://europepmc.org/articles/PMC9338778/
Autor:
Takafumi Suda, Senri Yamamoto, Hirotoshi Iihara, Chiemi Hirose, Ryuji Uozumi, Masato Karayama, Akio Suzuki, Yukiyoshi Fujita, Hisao Imai, Yoh Hayasaki, Ken-ichirou Morishige, Kazuto Nakamura, Yasushi Ohno, Naoki Inui, Hitoshi Kawazoe, K. Tanaka, Masakazu Abe
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-10 (2021)
BMC Cancer
BMC Cancer
Background The efficacy of olanzapine as an antiemetic agent in cancer chemotherapy has been demonstrated. However, few high-quality reports are available on the evaluation of olanzapine’s efficacy and safety at a low dose of 5 mg among patients tr
Autor:
William I. Bensinger, Nizar J. Bahlis, Jatin P. Shah, Heather J. Sutherland, Sonia Ammu, Cristina Gasparetto, Michael Kauffman, Sumit Madan, Richard Leblanc, Muhamed Baljevic, Christopher P. Venner, Ohad S. Bentur, Suzanne Lentzsch, Darrell White, Sascha A. Tuchman, Rami Kotb, Noa Biran, Chris Zhiyi Zhang, Christine Chen, Michael Sebag, Sharon Shacham, Adriana C Rossi, Brea Lipe, Gary J. Schiller, Natalie S. Callander, Dane Van Domelen, Andrew DeCastro, Osnat Ben-Shahar, Tianjun Zhou
Publikováno v:
British Journal of Cancer
British journal of cancer, vol 126, iss 5
British journal of cancer, vol 126, iss 5
Background Proteasome inhibitors (PIs), including carfilzomib, potentiate the activity of selinexor, a novel, first-in-class, oral selective inhibitor of nuclear export (SINE) compound, in preclinical models of multiple myeloma (MM). Methods The safe