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of 136
pro vyhledávání: ''
Autor:
William I. Bensinger, Nizar J. Bahlis, Jatin P. Shah, Heather J. Sutherland, Sonia Ammu, Cristina Gasparetto, Michael Kauffman, Sumit Madan, Richard Leblanc, Muhamed Baljevic, Christopher P. Venner, Ohad S. Bentur, Suzanne Lentzsch, Darrell White, Sascha A. Tuchman, Rami Kotb, Noa Biran, Chris Zhiyi Zhang, Christine Chen, Michael Sebag, Sharon Shacham, Adriana C Rossi, Brea Lipe, Gary J. Schiller, Natalie S. Callander, Dane Van Domelen, Andrew DeCastro, Osnat Ben-Shahar, Tianjun Zhou
Publikováno v:
British Journal of Cancer
British journal of cancer, vol 126, iss 5
British journal of cancer, vol 126, iss 5
Background Proteasome inhibitors (PIs), including carfilzomib, potentiate the activity of selinexor, a novel, first-in-class, oral selective inhibitor of nuclear export (SINE) compound, in preclinical models of multiple myeloma (MM). Methods The safe
Autor:
Masafumi Taniwaki, Koji Izutsu, Tadao Ishida, Takaaki Chou, Takashi Watanabe, Kenshi Suzuki, Naokuni Uike, Kiyohiko Hatake, Kensei Tobinai, Yoshihisa Shumiya, Takayuki Ishikawa, Kazutaka Sunami, Kiyoshi Ando, Morio Matsumoto, Shuji Ozaki, Hirohiko Shibayama, Shinsuke Iida
Publikováno v:
Cancer Science
This multicenter, open‐label phase 1/2 study evaluated single‐agent carfilzomib in 50 heavily pretreated Japanese patients with relapsed/refractory multiple myeloma (median of five prior treatments). In phase 1, patients were dosed at three level
Publikováno v:
Oncology Research
Apatinib is an oral TKI with antiangiogenic properties, and it is currently approved for the treatment of advanced gastric cancer in China. This agent has also been tested in other human solid tumors, including non-small cell lung cancer (NSCLC). Sin
Autor:
Patrick A. Ott, Rizwan Haq, Sushrut S. Waikar, F. Stephen Hodi, Girish S. Naik, Alistair E. W. Johnson, Elizabeth I. Buchbinder, Jonathan D. Schoenfeld
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-17 (2019)
Journal for Immunotherapy of Cancer
Journal for Immunotherapy of Cancer
Background A male gender driven obesity paradox (improved survival for overweight/obese patients compared to normal weight) was recently shown in melanoma in the context of checkpoint inhibition (anti-PD-1/anti-CTLA4 monotherapy) in a pooled meta-ana
Autor:
Gautam Borthakur, William Plunkett, Farhad Ravandi, Tapan M. Kadia, Barry D. Anderson, Naval Daver, Jane Waukau, Guillermo Garcia-Manero, Elias Jabbour, Monica Kwari, Kenzo Iizuka, Cheng Jin, Hagop M. Kantarjian, Courtney D. DiNardo, Chun Zhang, Nitin Jain
Publikováno v:
Cancer. 125:1665-1673
Background DFP-10917, a deoxycytidine nucleoside analogue, has a unique mechanism of action resulting in leukemic cell death when administered for prolonged periods at low doses. The current phase 1/2 study investigated the safety, maximum tolerated
Autor:
Fabio Piscaglia, Irene Pecora, Luca Ielasi, Giulia Rovesti, Vittorina Zagonel, Vincenzo Dadduzio, Mario Domenico Rizzato, Alessandro Granito, Francesca Benevento, Giorgia Marisi, Oronzo Brunetti, Francesco Tovoli, Fabio Conti, Federica Teglia, Giuseppe Cabibbo, Giulia Orsi, Mario Scartozzi, Andrea Casadei-Gardini, Alessandro Cucchetti, Francesco Giuseppe Foschi, Laura Gramantieri, Francesca Salani, Stefano Cascinu, Sara Lonardi, Antonella Argentiero, Caterina Vivaldi
Publikováno v:
Targeted oncology. 15(6)
Background: Inflammation is a long-established hallmark of liver fibrosis and carcinogenesis. Eosinophils are emerging as crucial components of the inflammatory process influencing cancer development. The role of blood eosinophils in patients with he
Autor:
Patricia Severns, Steven P. Treon, Joshua Gustine, Lian Xu, Guang Yang, Toni Dubeau, Zachary R. Hunter, Jorge J. Castillo, Kirsten Meid
Publikováno v:
Clinical Cancer Research. 24:3247-3252
Purpose: Proteasome inhibition is of proven efficacy in patients with Waldenström macroglobulinemia (WM). However, WM remains incurable with standard treatments. Novel agents, safe and effective, are needed. Patients and Methods: We designed a prosp
Autor:
Nayoung Han, Jae Hwan Oh, Hee Jin Chang, Jeongseon Kim, Ji Won Park, Hyun Yang Yeo, Byung Chang Kim, Sun-Young Kong
Publikováno v:
British Journal of Cancer
Background Immunomodulatory cytokines and systemic inflammatory markers are important during cancer development and progression. This study investigated the association and prognostic impact of systemic cytokine profiles and inflammatory markers in c
Autor:
Zhihong Ma, Yingrong Chen, Shunli Dong, Caihua Yu, Jin Liu, Qiuping Ding, Xuting Xu, Pengtao Song
Publikováno v:
Interactive CardioVascular and Thoracic Surgery. 26:395-401
OBJECTIVES Astrocyte elevated gene-1 (AEG-1) functions to mediate angiogenesis, and its upregulation is responsible for tumour angiogenesis during cancer development. This study analysed AEG-1 expression in non-small-cell lung cancer (NSCLC) for asso
Publikováno v:
In Vivo. 31:239-242
Background/aim To evaluate outcomes and toxicities of chemoradiation with a less intensive paclitaxel regimen for locally recurrent bladder cancer. Patients and methods Three elderly patients received simultaneous chemoradiation for recurrent muscle-