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Autor:
Ashish Panigrahi, Constantine S. Tam, Piers Blombery, Xiangting Chen, John F. Seymour, Dennis A. Carney, Andrew H. Wei, Thomas E Lew, Mary Ann Anderson, Andrew W. Roberts, Ella R. Thompson, David C. S. Huang, Tamia Nguyen, David Westerman, Michael A. Dengler, Victor S Lin, Sasanka M. Handunnetti, Jerry M. Adams
Publikováno v:
Blood. 139:1198-1207
The BCL2 inhibitor venetoclax has established therapeutic roles in chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML). As BCL2 is an important determinant of survival of both myeloid progenitor and B cells, we investigated whether cl
Publikováno v:
Nitric Oxide. 118:17-25
AIMS Patients with type 2 diabetes mellitus (T2DM) have reduced vasodilatory responses during exercise partially attributable to low nitric oxide (NO) levels. Low NO contributes to greater α-adrenergic mediated vasoconstriction in contracting skelet
Autor:
Pasquale Quattrone, Laura D. Locati, Salvatore Alfieri, Luigi Mariani, Paolo Bossi, Lisa Licitra, Cristiana Bergamini, Francesca Platini, Carlo Resteghini, Elena Colombo, Giuseppina Calareso, Iolanda Capone, Stefano Cavalieri
Publikováno v:
Journal of Clinical Oncology. 39:4061-4068
PURPOSE The activity of androgen-deprivation therapy (ADT) in androgen receptor–positive (AR+) salivary gland carcinomas (SGCs) has been established in the past few years. Second-line treatment in castration-resistant patients is still unknown. We
Autor:
Philipp B. Staber, Peter Bettelheim, Christian Sillaber, Gabriele Stefanzl, Dubravka Smiljkovic, Daniela Berger, Georg Greiner, Peter Valent, Karin Bauer, Wolfgang R. Sperr, Ana-Iris Schiefer, Susanne Gamperl, Ilse Schwarzinger, Renate Thalhammer, Gregor Hoermann, Paul Knöbl, Christoph Kornauth
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 12, Pp 1183-1191 (2021)
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.)
During progression of myeloid neoplasms, the basophil compartment may expand substantially and in some of these patients, a basophilic leukemia is diagnosed. In patients with Ph-chromosome+ chronic myeloid leukemia, acceleration of disease is typical
Autor:
Austyn Colter, James Ropa, Melissa L. Fishel, Brian Parkin, Maegan L. Capitano, Heiko Konig, George E. Sandusky, Claudiu T. Supuran, Callista Maguire, Fangli Chen, Daniela N. Petrusca, Max Jacobsen, Xue Wu, H. Scott Boswell, Emilia Licarete, Fabrizio Carta, Magdalena Czader
Publikováno v:
Journal of Cellular and Molecular Medicine
Acute myeloid leukaemia (AML) is an aggressive form of blood cancer that carries a dismal prognosis. Several studies suggest that the poor outcome is due to a small fraction of leukaemic cells that elude treatment and survive in specialised, oxygen (
Autor:
Charles E. Foucar, Rupali Roy Bhave, Darren King, Bernard L. Marini, Dan R. Robinson, Dale L. Bixby, Anthony J. Perissinotti, Lydia L. Benitez, Vincent Ma
Publikováno v:
Cancer Genetics. :57-60
The cornerstone of management in patients with acute promyelocytic leukemia (APL) is early diagnosis and prompt initiation of treatment with an all-trans retinoic acid (ATRA)-based regimen. Identification of the t(15;17)(PML-RARA) chromosomal translo
Publikováno v:
Anticancer Research. 41:5729-5737
Background/aim This study aimed to identify the predictive markers for carboplatin-induced severe thrombocytopenia. Patients and methods We conducted a retrospective cohort analysis of inpatients who received carboplatin and pemetrexed. Results Among
Autor:
Amy S. Ruppert, Larry Beaver, Bonnie K. Harrington, Janek S. Walker, Brandi R. Walker, Katie Williams, James Cronin, Zachary A. Hing, Alexander Pan, Jordan N. Skinner, Jennifer A. Woyach, Nyla A. Heerema, Steven Sher, Amy Lehman, Charles Thomas Gregory, Vincenzo Coppola, Rosa Lapalombella, Krzysztof Mrózek, Max Yano, Pearlly S. Yan, Hatice Gulcin Ozer, James S. Blachly, Jadwiga Labanowska, John C. Byrd, Casey Cempre
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
Nature Communications
Rare, recurrent balanced translocations occur in a variety of cancers but are often not functionally interrogated. Balanced translocations with the immunoglobulin heavy chain locus (IGH; 14q32) in chronic lymphocytic leukemia (CLL) are infrequent but
Autor:
Stephanie Burnett, Amit Bahl, Bruno Morgan, Lucy Tregellas, Lisa Pickering, Alastair Thomson, Emma Hall, Tony Elliott, Rachel Slade, Balaji Venugopal, Steve Nicholson, Naveen S. Vasudev, Holly Tovey, Clare Cruickshank, Peter Kirkbride, Alison Hassall, Anita Mitra
Publikováno v:
British Journal of Cancer
Background We investigated the first-line activity of vinflunine in patients with penis cancer. Cisplatin-based combinations are commonly used, but survival is not prolonged; many patients are unfit for such treatment or experience toxicity that outw
Autor:
Zhenmin Wang, Zhizhong Li, Guozhi Xiao, Canling Long, Songlin Peng, Zhiteng Bao, He Xiaoqin, Chen Gaoyang, Wanze Tang, Xin Chen, Dazhi Yang, Tan Baoyu, William W. Lu, Shang Wang
Publikováno v:
International Journal of Biological Sciences
Bone remodeling is a dynamic process between bone formation mediated by osteoblasts and bone resorption mediated by osteoclasts. Disrupted bone remodeling is a key factor in postmenopausal osteoporosis, a metabolic disorder characterized by deteriora