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Publikováno v:
Anticancer Research. 41:3977-3982
BACKGROUND/AIM Electrochemotherapy (ECT) is a cancer treatment modality where the efficacy of a chemotherapeutic agent is enhanced by an electrical field. It is an established palliative treatment for cutaneous metastases but its role in curative tre
Autor:
Koichi Takahashi, Naval Daver, Sanam Loghavi, Yesid Alvarado, Rasoul Pourebrahim, Abhishek Maiti, Tapan M. Kadia, Hagop M. Kantarjian, Musa Yilmaz, Nicholas J. Short, Kunhwa Kim, Courtney D. DiNardo, Maro Ohanian, Farhad Ravandi, Koji Sasaki, Marina Konopleva, Ken Furudate, Guilin Tang, Caitlin R. Rausch
Publikováno v:
Cancer. 127:3772-3781
BACKGROUND TP53 mutation (TP53mut ) confers an adverse prognosis in acute myeloid leukemia (AML). Venetoclax with hypomethylating agents is a current standard for older patients; however, recent reports suggest that TP53mut confers resistance to vene
Autor:
Banumathi Tamilselvan, Zachary Jackson, Susan Pereira Ribeiro, Jill S. Barnholtz-Sloan, Jaroslaw P. Maciejewski, David N. Wald, Kalpana Gupta, Ashish Sharma, Xuan Xu, Rafick-Pierre Sekaly, Robert Schauner, Anne Roe, Samuel Li, Robert S. Balderas, Tae Hyun Hwang, Lindsay Stetson, Slim Fourati, Marcos de Lima, Thomas LaFramboise, Dheepa Balasubramanian, Yogen Saunthararajah, Tammy Stefan
Publikováno v:
Leukemia
The prognosis of most patients with AML is poor due to frequent disease relapse. The cause of relapse is thought to be from the persistence of leukemia initiating cells (LIC's) following treatment. Here we assessed RNA based changes in LICs from matc
Autor:
Mingzhou Li, Jianmin Liu, Weixiang He, Daoquan Liu, Xun Fu, Ping Chen, Michael E. DiSanto, Xinhua Zhang, Xueneng Zhang, Xinghuan Wang, Guang Zeng, Yan Li
Publikováno v:
Clinical Science. 135:1591-1608
Benign prostatic hyperplasia (BPH) is a quite common illness but its etiology and mechanism remain unclear. Neural epidermal growth factor-like like 2 (NELL2) plays multifunctional roles in neural cell growth and is strongly linked to the urinary tra
Autor:
Jie Ji, Hongzhi Wang, Huanhu Zhang, Dahai Zhao, Shujie Wang, Rui Tao, Bo Hong, Jinfu Nie, Jian Qi, Ruifang Sun, Xiaopeng Zhang, Yanzhe Liu, Qingmei Deng
Publikováno v:
Cancer Science
Cell‐free methylated DNA immunoprecipitation and high‐throughput sequencing (cfMeDIP‐seq) is a new bisulfite‐free technique, which can detect the whole‐genome methylation of blood cell‐free DNA (cfDNA). Using this technique, we identified
Autor:
Sho Ikeda, Kentaro Narita, Yuto Takahashi, Daisuke Miura, Naoto Takahashi, Takafumi Tsushima, Akihiro Kitadate, Toshiki Terao, Kosei Matsue, Masami Takeuchi
Publikováno v:
Cancer Science
CD38 expression on myeloma cells is a critical factor affecting the early response to the anti‐CD38 antibody daratumumab. However, factors affecting CD38 expression in untreated multiple myeloma are not fully elucidated. In this study, we found tha
Autor:
Laurence Kraus-Berthier, Lucie Laplane, Véronique Saada, Céline Berthon, Maria E. Figueroa, Bouchra Badaoui, Margaux Sevin, Franck Debeurme, Eric Padron, Thorsten Braun, Qin Yang, Nathalie Droin, Raphael Itzykson, Guido Kroemer, Dorothée Selimoglu-Buet, Eric Solary, Oliver Kepp, Margot Morabito, Alix Derreal, Hannah Newman, Sylvain Thepot, Gabriel Etienne, Miguel Torres-Martin, Sébastien Banquet, Severine Badel, Orianne Wagner-Ballon, Pierre Fenaux
Publikováno v:
Blood
Blood, American Society of Hematology, 2021, 137 (24), pp.3390-3402. ⟨10.1182/blood.2020008729⟩
Blood, American Society of Hematology, 2021, 137 (24), pp.3390-3402. ⟨10.1182/blood.2020008729⟩
Mouse models of chronic myeloid malignancies suggest that targeting mature cells of the malignant clone disrupts feedback loops that promote disease expansion. Here, we show that in chronic myelomonocytic leukemia (CMML), monocytes that accumulate in
Autor:
Masayuki Ohtsuka, Katsunori Furukawa, Yoji Miyahara, Satoshi Kuboki, Satoshi Tomizawa, Mamoru Takada, Tsukasa Takayashiki, Shigetsugu Takano, Kosuke Sasaki
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-16 (2021)
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research : CR
Background Recent studies indicate that complement plays pivotal roles in promoting or suppressing cancer progression. We have previously identified C4b-binding protein α-chain (C4BPA) as a serum biomarker for the early detection of pancreatic ducta
Autor:
Wolf-Karsten Hofmann, Arwin Mehralivand, Laurenz Steiner, Nanni Schmitt, Ahmed Jawhar, Cleo-Aron Weis, Stefanie Uhlig, Justine Danner, Vladimir Riabov, Ali Darwich, Qingyu Xu, Julia Obländer, Eva Altrock, Tobias Boch, Nadine Weimer, Florian Nolte, Antje Knaflic, Mohamad Jawhar, Alexander Streuer, Verena Haselmann, Daniel Nowak, Johann-Christoph Jann, Verena Nowak, Alexander Marx, Georgia Metzgeroth, Johanna Flach, Iris Palme
Publikováno v:
Leukemia
Preclinical research of myelodysplastic syndromes (MDSs) is hampered by a lack of feasible disease models. Previously, we have established a robust patient-derived xenograft (PDX) model for MDS. Here we demonstrate for the first time that this model
Autor:
Jing-Jing Jiang, Masaaki Murakami, Ikuma Nakagawa, Shuhei Shimoyama, Shintaro Hojyo, Osamu Ohara, Tatsuya Atsumi, Mona Uchida, Isao Matsumoto, John A. Chiorini, Mitsutoshi Ota, Yuki Tanaka, Rie Hasebe, Daisuke Kamimura, Yoshinori Hasegawa
Publikováno v:
Int Immunol
Sjögren’s syndrome (SS) is an autoimmune disease characterized by inflammation with lymphoid infiltration and destruction of the salivary glands. Although many genome-wide association studies have revealed disease-associated risk alleles, the func