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Autor:
Teruhisa Sakamoto, Yoichiro Tada, Shuichi Takano, Wataru Miyauchi, Kyoichi Kihara, Kazushi Hara, Toshimichi Hasegawa, Yoshiaki Matsumi, Ken Sugesawa, Manabu Yamamoto, Yoshiyuki Fujiwara, Yuji Nakayama, Akimitsu Tanio, Chihiro Uejima
Publikováno v:
Anticancer Research. 41:4857-4865
Background/aim M1 macrophages have antitumour effects, while M2 macrophages promote tumour proliferation and invasion. The clinical significance of the M2-specific marker CD204 has not been elucidated in colorectal cancer (CRC). We investigated the p
Autor:
Hiroshi Yagi, Yuki Masuda, Taizo Hibi, Naoto Kubota, Hidenori Ojima, Yoko Fujii-Nishimura, Yuta Abe, Masahiro Shinoda, Minoru Kitago, Yasushi Hasegawa, Go Oshima, Yuko Kitagawa, Shutaro Hori, Michiie Sakamoto, Yusuke Takemura
Publikováno v:
Cancer Medicine, Vol 10, Iss 16, Pp 5599-5613 (2021)
Cancer Medicine
Cancer Medicine
Gamma‐synuclein (SNCG) promotes invasive behavior and is reportedly a prognostic factor in a range of cancers. However, its role in biliary tract carcinoma (BTC) remains unknown. Consequently, we investigated the clinicopathological significance an
Autor:
Mitsuaki Hirose, Masashi Sato, Ichinosuke Hyodo, Mamiko Imanishi, Kenji Yamato, Akinori Sugaya, Xiaoxuan Wang, Toshikazu Moriwaki, Xiaochen Zhang, Shinji Endo, Yoshiyuki Yamamoto
Publikováno v:
Anticancer Research. 41:1475-1483
Background/aim The oncoproteins murine double minute (MDM) 2 and MDM4 inactivate tumor-suppressor protein p53. Their mutual relationship with the prognosis of gastric cancer (GC) remains unknown. Patients and methods Expression of MDM2, MDM4, and p53
Publikováno v:
Journal of Immunology Research, Vol 2021 (2021)
Journal of Immunology Research
Journal of Immunology Research
Background. Preoperative chemoradiotherapy (pCRT) is a common and essential therapeutic strategy for patients with locally advanced rectal cancer (LARC), but poor tumor response and therapeutic resistance to chemoradiotherapy have appeared usually am
Autor:
Munetoshi Katagiri, Takeshi Naitoh, Hideaki Karasawa, Jun Sato, Michiaki Unno, Shimpei Maeda, Shinobu Ohnuma, Fuyuhiko Motoi, Shun Nakayama, Takashi Suzuki
Publikováno v:
Cancer Investigation. 38:214-227
Cripto-1 is a plasma membrane protein which is not expressed in adult tissue, but some tumors are accompanied by re-activation. We studied the clinical and biological significance of Cripto-1 in colorectal cancer. Cripto-1 was positive in 68 out of 1
Autor:
Manabu Kaneko, Kazushige Kawai, Masamichi Okada, Yasutaka Shuno, Hirofumi Sonoda, Soichiro Ishihara, Koji Murono, Takeshi Nishikawa, Hiroshi Shiratori, Toshiaki Tanaka, Hiroaki Ishii, Keisuke Hata, Kazuhito Sasaki, Hiroaki Nozawa, Tetsuo Ushiku, Shigenobu Emoto
Publikováno v:
Cancer Science
Postoperative distant metastasis dramatically affects rectal cancer patients who have undergone neoadjuvant chemoradiotherapy (NACRT). Here, we clarified the association between NACRT‐mediated mammalian target of rapamycin (mTOR) signaling pathway
Publikováno v:
Molecular Medicine Reports
Histone deacetylase 9 (HDAC9) is involved in a variety of malignant tumors, and leads to malignant tumor development and poor prognosis. However, the association between HDAC9 expression, and the prognosis and clinicopathological features of patients
Autor:
Wei-Dong Jia, Jian Gao
Publikováno v:
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
BACKGROUND Previous studies have reported that ARHGEF39 might be frequently upregulated in different cancer types and relevant to cancer progression. However, the expression pattern and clinicopathological features of ARHGEF39 in patients with hepato
Autor:
Panagiotis Sarantis, Maria Michelli, Dimitrios Schizas, Michalis V. Karamouzis, Stamatios Theoharis, Georgia Kyriakopoulou, Athanasios G. Papavassiliou, Ioanna Giannopoulou, Ilenia Chatziandreou, Evangelos Koustas, Angelica A. Saetta
Publikováno v:
American Journal of Clinical Oncology
Supplemental Digital Content is available in the text.
Objectives: Autophagy plays a dual role in tumorigenesis. In the initial stages, it promotes cell survival and suppresses carcinogenesis, whereas in cancer development, it induces cancer cel
Objectives: Autophagy plays a dual role in tumorigenesis. In the initial stages, it promotes cell survival and suppresses carcinogenesis, whereas in cancer development, it induces cancer cel
Autor:
Ya-Jie Tang, Xiao Yang, Xin-hua Liang, Ya-ling Tang, Sha-sha Wang, Min Zheng, Xin Pang, Mei Zhang, Xiao-lei Gao, Jia-Shun Wu, Jing-biao Wu, Xiang-hua Yu
Publikováno v:
Molecular Carcinogenesis. 58:1809-1821
Macrophage migration inhibitory factor (MIF) has been shown to closely associate with the malignant progression of a variety of human carcinomas. However, the role and its underlying molecular mechanisms of MIF in the invasion and metastasis of oral