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Autor:
Kazuya Shinmura, Yuji Iwashita, Masayuki Tanahashi, Kazuhito Funai, Haruhiko Sugimura, Takafumi Suda, Katsuhiro Yoshimura, Naoki Inui, Hiroshi Niwa, Masato Karayama, Hidetaka Yamada, Akikazu Kawase, Yusuke Inoue, Hiroshi Ogawa, Kazuo Tsuchiya
Publikováno v:
Lung Cancer. 141:21-31
Alterations in the MET gene, such as mutations and high-level amplification, are important drivers of non-small cell lung cancer (NSCLC). The efficacy of immune checkpoint inhibitors (ICIs) in lung cancer with MET abnormalities is unclear. We evaluat
Autor:
Dimitrios Peschos, Dimitrios Kikidis, Vasileios Papanikolaou, Efthymios Kyrodimos, Nicholas S Mastronikolis, Christos Riziotis, Evangelos Tsiambas, Vasileios Ragos, Aristeidis Chrysovergis
Publikováno v:
Asian Pacific Journal of Cancer Prevention : APJCP
Background: Deregulation of critical proteins involved in cell cycle stability, such as cyclins, is a frequent genetic event in the development and progression of solid malignancies. Concerning laryngeal squamous cell carcinoma (LSCC), cyclin D1 onco
Autor:
Bo-Hua Su, Dali Zheng, Yong Zhao, Shuo Yuan, Rui-Huan Gan, Xiao-ting Wu, Li Huang, Lisong Lin, You-Guang Lu
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-12 (2020)
BMC Cancer
BMC Cancer
BackgroundMatrix metalloproteinase 7 (MMP7), as the smallest member of the matrix metalloproteinase family, has been verified to be implicated in cancer progression, especially metastasis. However, its expression pattern and function in tongue cancer
Publikováno v:
Ear, Nose & Throat Journal. 100:578S-583S
Introduction: In squamous cell carcinomas of the oral cavity, factors that can predict prognosis are being studied. However, new prognostic factors are needed to provide information on the biological properties of tumors. Galectin-3 is known to be in
Autor:
Rina Jiromaru, Takahiro Hongo, Takashi Nakagawa, Yui Nozaki, Kazuki Hashimoto, Muneyuki Masuda, Yoshinao Oda, Kenichi Taguchi, Hidetaka Yamamoto, Ryuji Yasumatsu
Publikováno v:
American Journal of Surgical Pathology. 44:305-315
The prevalence and prognostic value of human papillomavirus (HPV) infection and epidermal growth factor receptor (EGFR) alteration in sinonasal squamous cell carcinoma (SNSCC) are not known. The reliability of p16 overexpression as a surrogate for HP
Publikováno v:
Cancer Cytopathol
BACKGROUND The management of high-risk human papillomavirus (HR-HPV)-related oropharyngeal head and neck squamous cell carcinomas (HNSCCs) are distinct from HNSCC linked to smoking and alcohol use. HR-HPV-positive HNSCC frequently presents as a cervi
Autor:
Henrik Møller, Stuart Winter, Valentine M. Macaulay, Ali Qureishi, Tamara Aleksic, Guillaume Rieunier, Ketan A. Shah
Publikováno v:
Clinical Otolaryngology. 44:1026-1036
Objectives Patients failing radiotherapy for laryngeal squamous cell carcinoma (LSCC) often require salvage total laryngectomy which has major functional consequences, highlighting a need for biomarkers of radiotherapy resistance. In other tumour typ
Autor:
Po-Wen Gu, Chia-Wei Hsu, Hao-Ping Liu, Yenlin Huang, Kai-Ping Chang, Wei-Chen Yen, Pei-Chun Hsueh, Chih-Ching Wu
Publikováno v:
Mol Cell Proteomics
Patients with oral cavity squamous cell carcinoma (OSCC) are frequently first diagnosed at an advanced stage, leading to poor prognosis and high mortality rates. Early detection of OSCC using body fluid-accessible biomarkers may improve the prognosis
Autor:
Kan Li, Jingyuan Li, Yujie Liang, Si-yong Gao, Di-kan Wang, Le Yang, Chenyu Guan, Gui-qing Liao, Guang-sen Zheng, Si-en Zhang, Dai-qiao Ouyang, Xiaomei Lao
Publikováno v:
EBioMedicine
EBioMedicine, Vol 48, Iss, Pp 70-80 (2019)
EBioMedicine, Vol 48, Iss, Pp 70-80 (2019)
Background: FOXO3a has been widely regarded as a tumor suppressor. It also plays a paradoxical role in regulating the cancer stem cells (CSCs), responsible for tumor-initiation, chemo-resistance, and recurrence in various solid tumors, including oral
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-14 (2021)
BMC Cancer
BMC Cancer
Background N6-methyladenine (m6A) is the most common modification of mRNA and IncRNA in higher organisms. m6A has been confirmed to be related to the formation and progression of tumors and m6A-related genes can be used as prognostic biomarkers in a