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Autor:
Yan-Fen Feng, Ling Deng, Hai-Yun Wang, Ying-Qing Li, Tao Tang, Fang Wang, Ya-Kang Long, Xin-Hua Yang, Xiao Zhang, Yuan He, Xu Zhang
Publikováno v:
Cancer Research and Treatment : Official Journal of Korean Cancer Association
Purpose Current variability in methods for tumor mutational burden (TMB) estimation and reporting demonstrates the urgent need for a homogeneous TMB assessment approach. Here, we compared TMB distributions in different cancer types using two customiz
Autor:
André Salim Khayat, Ana Paula Silva de Azevedo dos Santos, Edivaldo Herculano Corrêa de Oliveira, Jenilson da Silva, Luciane R. Cavalli, Leudivan Ribeiro Nogueira, Amanda Jordão Silva de Deus, Rafael Marchi, Silma Regina Ferreira Pereira, Ronald Coelho
Publikováno v:
Cancer Biomarkers. 32:147-160
BACKGROUND: Penile cancer (PeCa) is a rare disease, but its incidence has increased worldwide, mostly in HPV+ patients. Nevertheless, there is still no targeted treatment for this carcinoma. OBJECTIVE: To predict the main signaling pathways involved
Autor:
Ke Tan, Yumei Fan, Yan-Zhong Chang, Yanxiu Meng, Pengxiu Cao, Fei Chen, Bing Liu, Bo Zhang, Bihui Han, Yu Han
Publikováno v:
Aging (Albany NY)
Breast-invasive carcinoma (BRCA) is the most frequent and malignant tumor in females. Ceruloplasmin (CP) is a multifunctional molecule involved in iron metabolism, but its expression profile, prognostic potential and relationship with immune cell inf
Autor:
Naoki Yanagawa, Wataru Habano, Mitsumasa Osakabe, Tamotsu Sugai, Makoto Eizuka, Yoshihito Tanaka, Ryo Sugimoto, Hiromu Suzuki, Takayuki Matsumoto
Publikováno v:
Pathology International
Identification of molecular alterations occurring in the adenomatous and carcinomatous components within the same tumor would greatly enhance understanding of the neoplastic progression of colorectal cancer. We examined somatic copy number alteration
Autor:
Salvatore Siena, Emilia Maria Cristina Mazza, Giulia Della Chiara, Chiara Godano, Nicola Zucchini, Valeria Ranzani, Stefania Oliveto, Paola Gruarin, Jens Geginat, Roberto Bosotti, Claudia D'Oria, Elena Carelli, Pierluigi Novellis, Saveria Mazzara, Ylenia Silvestri, Marco Passaro, Alessio Amatu, Marco Alloisio, Antonio Lanzavecchia, Stefano Biffo, Giorgia Alvisi, Federica Gervasoni, Maria Lucia Sarnicola, N. Mariani, Alberto Bardelli, Ramona Bason, Jolanda Brummelman, Mariangela Lorenzo, Giulia Veronesi, Emanuela Bonoldi, Massimiliano Pagani, Daniele Prati, Enrico Opocher, Lorenzo Drufuca, Martina Martinovic, Andrea Sartore-Bianchi, Sergio Abrignani, Alessandro Giani, Marco De Simone, Enrico Lugli, Chiara Cordiglieri, Serena Curti, Grazisa Rossetti, Valeria Bevilacqua, Andrea Pisani Ceretti, Raoul J. P. Bonnal
Publikováno v:
Nature Immunology, 22, 735-745
Nature Immunology, 22, 6, pp. 735-745
Nature Immunology, 22, 6, pp. 735-745
Regulatory T (Treg) cells are a barrier for tumor immunity and a target for immunotherapy. Using single-cell transcriptomics, we found that CD4+ T cells infiltrating primary and metastatic colorectal cancer and non-small-cell lung cancer are highly e
Autor:
Anna Cremonini, Francesco Limarzi, Cecily Quinn, Enrico Di Oto, Riccardo Masetti, Alejandro Martin Sanchez, Caterina Ravaioli, Angelo Gianluca Corradini, Luca Saragoni, Luca Morandi, Maria C. Cucchi, Maria Pia Foschini
Publikováno v:
Virchows Archiv
Carcinomas with apocrine differentiation (CAD) of the breast are rare tumours typically presenting high immunohistochemical expression of androgen receptor (AR) which is a target molecule for personalised therapy. To date, no studies have evaluated t
Publikováno v:
Cancer Research. 81:344-355
Circular RNAs (circRNA) are a new member of endogenously produced noncoding RNAs that have been characterized as key regulators of gene expression in a variety of malignances. However, the role of circRNA in oral squamous cell carcinoma (OSCC) remain
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports
Scientific Reports
Gastric cancer (GC) is a leading cause of cancer-induced mortality, with poor prognosis with metastasis. The mechanism of gastric carcinoma lymph node metastasis remains unknown due to traditional bulk-leveled approaches masking the roles of subpopul
Autor:
Fang Li, Fang Lv, Xingkai Li, Kun Yang, Xuezhi Hao, Yicheng Liang, Hengqi Chen, Bing Wang, Yushun Gao
Publikováno v:
Cell Death and Disease, Vol 11, Iss 11, Pp 1-14 (2020)
Cell Death & Disease
Cell Death & Disease
Numerous studies have reported the association of long non-coding RNAs (lncRNAs) in cancers, yet the function of lncRNA high expressed in hepatocellular carcinoma (HEIH) in esophageal carcinoma (EC) has seldom been explored. Here, we aimed to explore
Autor:
Michael Behring, Hyung-Gyoon Kim, Sooryanarayana Varambally, Balabhadrapatruni V. S. K. Chakravarthi, Pran K. Datta, Prachi Bajpai, Amr Elkholy, Sameer Al Diffalha, Sumit Agarwal, Martin J. Heslin, Darshan S. Chandrashekar, Nirzari Gupta, Upender Manne
Publikováno v:
Molecular Oncology
This study demonstrates overexpression of TRIP13 in colorectal cancers is independent of patient's gender, age, race/ethnicity, pathologic stage (primary and liver metastatic lesions), and p53 and microsatellite instability status. Furthermore, it es