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Autor:
Lajos Pusztai, Gabriel N. Hortobagyi, Bryan T. Hennessy, Massimo Cristofanilli, Chafika Mazouni, Fabrice Andre, Attila Tordai, W. Fraser Symmans, Cornelia Liedtke, Marjorie C. Green, Ana M. Gonzalez-Angulo, Kenneth R. Hess, Jaime A. Mejia
Publikováno v:
Journal of Clinical Oncology. 41:1809-1815
PURPOSE Triple-negative breast cancer (TNBC) is defined by the lack of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER-2) expression. In this study, we compared response to neoadjuvant chemotherap
Autor:
C. Meyer, Y. Fouché, Emmanuel Chamorey, M. Dejode, C. Bailleux, J. Haudebourg, Renaud Schiappa, Y. Delpech, Emmanuel Barranger
Publikováno v:
Clinical Breast Cancer. 22:121-126
Background Delays in initiating adjuvant chemotherapy after breast cancer surgery seems to have an impact on patients’ risk of relapse and their survival rate. The aim of this retrospective study was to identify factors delaying initiation of adjuv
Autor:
Fei Ma, Yanxia Sun, Qing Li, Peng Yuan, Shanshan Chen, Jiayu Wang, Yang Luo, Ying Fan, Pei Yu, Binghe Xu, Yiqun Han, Ruigang Cai, Qiao Li, Pin Zhang
Publikováno v:
Clinical Breast Cancer. 21:e497-e505
Different clinicopathologic characteristics could contribute to inconsistent prognoses of small breast neoplasms (T1a/T1b). This study was done to conduct a retrospective analysis and establish a clinical prediction model to predict individual surviv
Autor:
Manish R. Patel, Peng He, Antoinette R. Tan, Anita Scheuber, Shannon Marshall, Anton I. Rosenbaum, Kemal Balic, Erika Hamilton, Mark D. Pegram, Mayukh Das, Meina Liang, Anna Maria Storniolo
Publikováno v:
Molecular Cancer Therapeutics. 20:1442-1453
MEDI4276 is a biparatopic tetravalent antibody targeting two nonoverlapping epitopes in subdomains 2 and 4 of the HER2 ecto-domain, with site-specific conjugation to a tubulysin-based microtubule inhibitor payload. MEDI4276 demonstrates enhanced cell
Autor:
Xiao-Ou Shu, Ingrid A. Mayer, Wei Zheng, Christina E. Bailey, Jennifer A. Pietenpol, Fei Wang
Publikováno v:
Cancer Research. 81:1163-1170
It is unclear whether racial/ethnic disparities in triple-negative breast cancer (TNBC) mortality remain after accounting for clinical characteristics, treatment, and access-to-care–related factors. In this study, women with a primary diagnosis of
Autor:
Bella Pajares, Sofia Ruiz-Medina, Enrique Saez, Antonia Márquez, Laura Galvez, Begoña Jimenez, Ana Godoy, Pablo Rodriguez-Brazzarola, Maria E. Dominguez-Recio, Francisco Carabantes, Alfonso Sánchez-Muñoz, María José Bermejo, Irene López, José M. Jerez, Tamara Diaz-Redondo, Ester Villar, Héctor Mesa, Leo Franco, Nuria Ribelles, Emilio Alba
Publikováno v:
European Journal of Cancer. 144:224-231
Background CDK4/6 inhibitors plus endocrine therapies are the current standard of care in the first-line treatment of HR+/HER2-negative metastatic breast cancer, but there are no well-established clinical or molecular predictive factors for patient r
Autor:
Brittney S Zimmerman, Krystal Pauline Cascetta, Amy Tiersten, Erin Moshier, Meng Ru, Danielle Seidman
Publikováno v:
Oncology. 99:280-291
Introduction: The aim of this study was to assess for clinicopathologic and socioeconomic features that predict improved survival for patients with advanced breast cancer with synchronous brain metastases at diagnosis. Methods: We utilized the Nation
Autor:
Sture Löfgren, Bengt-Åke Andersson, Mats Nilsson, Freddi Lewin, Nongnit Laytragoon Lewin, Delmy Oliva
Publikováno v:
Oncology
Introduction: It has been suggested that age could influence the treatment-induced side effects and survival time of cancer patients. The influence of age on blood-based biomarkers, acute radiation skin reactions (ARSRs), and survival time of breast
Autor:
So-Youn Jung, Jiwon Lim, Hyeong In Ha, Myong Cheol Lim, Young-Joo Won, Yoon Jung Chang, Eungyeong Lee
Publikováno v:
Cancer Research and Treatment : Official Journal of Korean Cancer Association
Purpose A prior history of breast cancer is a risk factor for the subsequent development of primary peritoneal, epithelial ovarian, and fallopian tubal (POFT) cancers. This study aimed to estimate the incidence of secondary POFT malignancy in breast
Publikováno v:
British Journal of Cancer
Background Expensive cancer treatment calls for alternative ways such as drug repurposing to develop effective drugs. The aim of this study was to analyse the effect of post-diagnostic use of cholera vaccine on survival outcome in breast cancer patie