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Publikováno v:
Journal of Clinical Oncology. 41:1331-1338
PURPOSE Immunohistochemistry (IHC) is a newer technique for assessing the estrogen receptor (ER) status of breast cancers, with the potential to overcome many of the shortcomings associated with the traditional ligand-binding assay (LBA). The purpose
Autor:
Kensuke, Yamamura, Toru, Beppu, Keijiro, Inoue, Kazuki, Matsumura, Eri, Oda, Yasunori, Nagayama, Toshihiko, Motohara, Hideaki, Miyamoto, Yoshihiro, Komohara, Hirohisa, Okabe, Tatsunori, Miyata, Takatoshi, Isiko
Publikováno v:
Anticancer Research. 42:5663-5670
Hepatocellular carcinoma (HCC) with bile duct tumor thrombus (BDTT) is highly malignant; therefore, continual, multidisciplinary treatments are essential.In this study, two 78- and 81-year-old men were treated with the Vater papilla-preserving strate
Autor:
Hanae Ida, Takafumi Koyama, Takaaki Mizuno, Kuniko Sunami, Takashi Kubo, Kazuki Sudo, Kayoko Tao, Makoto Hirata, Kan Yonemori, Ken Kato, Takuji Okusaka, Yuichiro Ohe, Yoshiyuki Matsui, Naoya Yamazaki, Chitose Ogawa, Akira Kawai, Yoshitaka Narita, Minoru Esaki, Noboru Yamamoto
Publikováno v:
Cancer Science. 113:4300-4310
Previous clinical trials indicate that 10%-25% of patients received genomically matched therapy after comprehensive genomic profiling (CGP) tests. However, the clinical utility of CGP tests has not been assessed in clinical practice. We assessed the
Autor:
Abbas Agaimy, Josephine K. Dermawan, Iona Leong, Robert Stoehr, David Swanson, Ilan Weinreb, Lingxin Zhang, Cristina R. Antonescu, Brendan C. Dickson
Publikováno v:
Genes, Chromosomes and Cancer. 61:701-709
The mammalian Vestigial-like (VGLL) transcriptional cofactor family of proteins VGLL1-4 has recently emerged as an important player in the tumorigenesis of diverse neoplasms. The role of VGLL3 in soft tissue tumors is exemplified by its amplification
Publikováno v:
Combinatorial Chemistry & High Throughput Screening. 25:1767-1777
Background: Synovial sarcoma (SS) refers to a malignant soft tissue sarcoma (STS) which often comes about to children and adults and has a poor prognosis in elderly patients. Patients with local lesions can be treated with extensive surgical resectio
Autor:
HARUKA YOSHII, KAZUMASA SEKIHARA, YUKA IDETA, SHINTARO NAKAJIMA, IKUMA KATO, MAKIKO OKUBO-SATO, KEI SUGIURA, KENJI MITSUDO, MITOMU KIOI
Publikováno v:
Anticancer Research. 42:3815-3823
SIRT6 is one of seven human sirtuin genes and is known to act as an onco-suppressor gene in colorectal and ovarian cancers, although it is up-regulated in other cancers. Thus, SIRT6 is considered performing both tumor-suppressing and promoting roles.
Autor:
Bassel Nazha, Tony Z Zhuang, Hiba I Dada, Leylah M Drusbosky, Jacqueline T Brown, Deepak Ravindranathan, Bradley C Carthon, Omer Kucuk, Jamie Goldman, Viraj A Master, Mehmet Asim Bilen
Publikováno v:
The Oncologist. 27:462-468
Background Adrenocortical carcinoma (ACC) is a rare and heterogeneous malignancy with poor prognosis. We aimed to evaluate the feasibility of next-generation sequencing (NGS) testing of circulating cell-free tumor DNA (ctDNA) in patients with ACC, to
Autor:
Andrea Leith, Amanda Ribbands, Jeri Kim, Matthew Last, Sophie Barlow, Lingfeng Yang, Sameer R Ghate
Publikováno v:
Future Oncology. 18:937-951
Aim: To assess homologous recombination repair mutation (HRRm) testing patterns in metastatic castration-resistant prostate cancer. Methods: A point-in-time, international survey conducted January–August 2020. Results: Three-quarters of physicians
Autor:
Tsutomu, Yoshida, Go, Ogura, Mikiko, Tanabe, Takuo, Hayashi, Chiho, Ohbayashi, Mizutomo, Azuma, Chikara, Kunisaki, Yoichi, Akazawa, Soji, Ozawa, Sohei, Matsumoto, Takayoshi, Suzuki, Akira, Mitoro, Tetsu, Fukunaga, Akiko, Shimizu, Go, Fujimoto, Takashi, Yao
Publikováno v:
Cancer Biology & Therapy. 23:191-200
This real-world study examined the prevalence of programmed death ligand-1 (PD-L1) expression and assessed the frequency of microsatellite instability-high (MSI-H) status and Epstein-Barr virus (EBV) positivity in Japanese patients with advanced gast
Autor:
TAKEHIRO OTOSHI, TATSUYA NAGANO, JONGUK PARK, KOJI HOSOMI, TOMOYA YAMASHITA, MOTOKO TACHIHARA, TOKIKO TABATA, REINA SEKIYA, YUGO TANAKA, KAZUYUKI KOBAYASHI, KENJI MIZUGUCHI, TOMOO ITOH, YOSHIMASA MANIWA, JUN KUNISAWA, YOSHIHIRO NISHIMURA
Publikováno v:
Anticancer Research. 42:1589-1598
The gut microbiome plays an important role in the immune system and has attracted attention as a biomarker of several diseases, including cancer. In this study, we examined the relationship between the gut microbiome and lung cancer progression.Femal