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Publikováno v:
Anticancer Research. 41:4645-4650
Background/aim Previous reports have indicated that increased expression of Jagged-1 (JAG1) may predict chemotherapy response and poor prognosis for patients with recurrent or metastatic colorectal cancer (CRC). This study aimed to investigate the cl
Autor:
Alain Bergeron, France-Hélène Joncas, Aerin Park, Clovis Boibessot, Jean-François Pelletier, Paul Toren, Typhaine Gris, Zohra Berrehail
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports
Scientific Reports
Within the prostate tumor microenvironment (TME) there are complex multi-faceted and dynamic communication occurring between cancer cells and immune cells. Macrophages are key cells which infiltrate and surround tumor cells and are recognized to sign
Autor:
Toru Aoyama, Masakatsu Numata, Hayato Watanabe, Yukihiko Hiroshima, Naoto Yamamoto, Itaru Hashimoto, Hiroshi Saeki, Manabu Shiozawa, Kazuki Kano, Takanobu Yamada, Takashi Oshima, Yayoi Kimura, Sumito Sato, Norio Yukawa, Shinsuke Nagasawa, Soichiro Morinaga, Yohei Miyagi, Yasushi Rino, Munetaka Masuda, Kazuhito Tsuchida, Hiroshi Tamagawa, Takashi Ogata
Publikováno v:
Anticancer Research. 41:4489-4495
Background/aim The chemokine receptors C-X-C chemokine receptor type 4 (CXCR4) and C-C chemokine receptor type 7 (CCR7) play an important role in the invasion and metastasis of cancer. This study investigated the relationship between relative express
Autor:
Ye Jin Ha, Seon Ae Roh, Ka Hee Tak, Chan Wook Kim, Yong Sung Kim, Seon-Young Kim, Seon-Kyu Kim, Jin Cheon Kim, Dong-Hyung Cho
Publikováno v:
Anticancer Research. 41:4651-4658
Background/aim We evaluated the predictive value of candidate serum biomarkers for recurrence in stage II and III colorectal cancer (CRC) after curative surgery. Patients and methods A total of 33 and 120 patients with CRC with or without recurrence
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-14 (2021)
BMC Cancer
BMC Cancer
Background Ubiquitously transcribed tetratricopeptide repeat on chromosome X (UTX) has been identified as a histone 3 lysine 27 (H3K27) demethylase and acted as a tumor suppressor gene or oncogenic function. The current study was to explore the signi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports
Aldosterone reductase family 1 member B10 (AKR1B10) is a nicotinamide adenine dinucleotide phosphate (NADPH) (reduced coenzyme II)-dependent oxidoreductase, and its biological functions include carbonyl detoxification, hormone metabolism, osmotic adj
Autor:
Hee Kyung Kim, Jihyun Kwon, Seonggyu Byeon, Yaewon Yang, Seung-Myoung Son, Ki Hyeong Lee, Yusook Jeong, Hye Sook Han
Publikováno v:
Anticancer Research. 41:4497-4504
Background/aim E-Cadherin has been implicated in cell-cell adhesion, and soluble E-cadherin is involved in angiogenesis and resistance to anti-angiogenic therapy in several cancer types. This study aimed to investigate the expression and clinical sig
Autor:
Michelangelo Fiorentino, Filippo Gustavo Dall'Olio, Rita Golfieri, Laura Marcolin, Benedetta Fragomeno, Giada Grilli, Giulia Manferrari, Andrea Ardizzoni, Francesca Sperandi, Mario Terracciano, Nastassja Tober, Francesco Gelsomino, Nicole Conci, Francesca Fontana, Andrea De Giglio, Stefano Brocchi
Publikováno v:
Clinical Lung Cancer. 22:423-431
Background: Circulating tumor cells (CTCs) are a promising source of biological information in cancer. Data correlating PD-L1 expression in CTCs with patients’ response to immune checkpoint inhibitors (ICIs) in non–small-cell lung cancer (NSCLC)
Autor:
Xiaoxuan Sun, Yaojun Peng, Juan Yang, Qiyan Wu, Dong Zhang, Huan Wang, Qi Chen, Jing Zhao, Gaowa Sharen, Fan Yin
Publikováno v:
FEBS Open Bio, Vol 11, Iss 9, Pp 2490-2506 (2021)
FEBS Open Bio
FEBS Open Bio
The accumulation of various genetic and epigenetic changes in colonic epithelial cells has been identified as one of the fundamental processes that drive the initiation and progression of colorectal cancer (CRC). This study aimed to explore functiona
Autor:
Daniel F. Hayes, Roy S. Herbst, Jonathan L. Myles, Suzanne L. Topalian, Sophia L. Yohe, Naomi Aronson, Andrew M. Bellizzi, Upal Basu Roy, Georganne Bradshaw, Robin H. Edwards, Ehab A. El-Gabry, Julia Elvin, Thomas F. Gajewski, Lisa M. McShane, Matthew Oberley, Reena Philip, David L. Rimm, Jason N. Rosenbaum, Eric H. Rubin, Lisa Schlager, Shimere W. Sherwood, Mark Stewart, Janis M. Taube, Magdalena Thurin, Patricia Vasalos, Jordan Laser
Publikováno v:
JCO precision oncology. 6
PURPOSE Immune checkpoint inhibition (ICI) therapy represents one of the great advances in the field of oncology, highlighted by the Nobel Prize in 2018. Multiple predictive biomarkers for ICI benefit have been proposed. These include assessment of p